Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Kristof Zarschler"'
Autor:
Fabian Krutzek, Cornelius K. Donat, Martin Ullrich, Kristof Zarschler, Marie-Charlotte Ludik, Anja Feldmann, Liliana R. Loureiro, Klaus Kopka, Sven Stadlbauer
Publikováno v:
Cancers, Vol 15, Iss 9, p 2638 (2023)
Noninvasive molecular imaging of the PD-1/PD-L1 immune checkpoint is of high clinical relevance for patient stratification and therapy monitoring in cancer patients. Here we report nine small-molecule PD-L1 radiotracers with solubilizing sulfonic aci
Externí odkaz:
https://doaj.org/article/9130097e494d4042ab799e179758d858
Autor:
Falco Reissig, David Bauer, Kristof Zarschler, Zbynek Novy, Katerina Bendova, Marie-Charlotte Ludik, Klaus Kopka, Hans-Jürgen Pietzsch, Milos Petrik, Constantin Mamat
Publikováno v:
Cancers, Vol 13, Iss 8, p 1974 (2021)
Currently, targeted alpha therapy is one of the most investigated topics in radiopharmaceutical cancer management. Especially, the alpha emitter 225Ac has excellent nuclear properties and is gaining increasing popularity for the treatment of various
Externí odkaz:
https://doaj.org/article/2c7382675f2e427390ef558d2dc42504
Autor:
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution
Externí odkaz:
https://doaj.org/article/df49b90ff84b43d9acf32897f9f258e4
Autor:
Robin Ristl, Kerstin Steiner, Kristof Zarschler, Sonja Zayni, Paul Messner, Christina Schäffer
Publikováno v:
International Journal of Microbiology, Vol 2011 (2011)
The amazing repertoire of glycoconjugates present on bacterial cell surfaces includes lipopolysaccharides, capsular polysaccharides, lipooligosaccharides, exopolysaccharides, and glycoproteins. While the former are constituents of Gram-negative cells
Externí odkaz:
https://doaj.org/article/02a6f6f41444483ca643979573e8b1b2
Autor:
Patrick Cieslik, Manja Kubeil, Kristof Zarschler, Martin Ullrich, Florian Brandt, Karl Anger, Hubert Wadepohl, Klaus Kopka, Michael Bachmann, Jens Pietzsch, Holger Stephan, Peter Comba
Publikováno v:
Journal of the American Chemical Society 144(2022)47, 21555-21567
We report a nonadentate bispidine (3,7-diazabicyclo[3.3.1]nonane) that unveils the potential to bind theranostically relevant radionuclides, including indium-111, lutetium-177 and actinium-225 at mild labeling conditions. This radiopharmaceutical can
Autor:
Hua Yang, Chris Orvig, Luke Wharton, Manja Kubeil, Xiaozhu Wang, Holger Stephan, Lily Southcott, Kristof Zarschler, María de Guadalupe Jaraquemada-Peláez, Neha Choudhary, Brian O. Patrick
Publikováno v:
Inorganic Chemistry. 60:12186-12196
A new versatile chelating ligand for intermediate size and softness radiometals [64Cu]Cu2+ and [111In]In3+, H2pyhox, was synthesized by introducing pyridine as a new donor moiety to complement 8-hydroxyquinoline on an ethylenediamine backbone. The co
Autor:
Martin Ullrich, Martin Walther, Hans-Jürgen Pietzsch, Kristof Zarschler, Ian Moore F. Gilpin, Thomas Wünsche, Jens Pietzsch, Ondřej Lebeda
Publikováno v:
Chemmedchem
We show the synthesis of an in vivo stable mercury compound with functionality suitable for radiopharmaceuticals. The designed cyclic bisarylmercury was based on the water tolerance of organomercurials, higher bond dissociation energy of Hg−Ph to H
Autor:
Adrian Wünsche, Kristof Zarschler, Birgit Belter, Stephan Holger, Klaus Kopka, Jens Pietzsch, Manja Kubeil
Publikováno v:
Nuclear Medicine and Biology. :S74-S75
Autor:
Falco Reissig, Kristof Zarschler, Zbynek Novy, Milos Petrik, Katerina Bendova, Daniela Kurfurstova, Jan Bouchal, Marie-Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Jürgen Pietzsch, Marian Hajduch, Constantin Mamat
Publikováno v:
Theranostics 12(2022), 7203-7215
Rationale: Small 225Ac-labeled prostate-specific membrane antigen (PSMA)-targeted radioconjugates have been described for targeted alpha therapy of metastatic castration-resistant prostate cancer. Transient binding to serum albumin as a highly abunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8b8c884205da5c842281f61ee28cb
https://www.hzdr.de/publications/Publ-34927-1
https://www.hzdr.de/publications/Publ-34927-1
Autor:
Xiaozhu Wang, Holger Stephan, Manja Kubeil, Chris Orvig, Marı A de Guadalupe Jaraquemada-Peláez, Valery Radchenko, Kristof Zarschler, Neha Choudhary
Publikováno v:
Inorganic Chemistry. 59:5728-5741
[44/47Sc]Sc3+, [68Ga]Ga3+, and [111In]In3+ are the three most attractive trivalent smaller radiometalnuclides, offering a wide range of distinct properties (emission energies and types) in the tool...