Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Kristof Zarschler"'
Autor:
Falco Reissig, Dr. Kristof Zarschler, Dr. René Hübner, Dr. Hans‐Jürgen Pietzsch, Prof. Dr. Klaus Kopka, Dr. Constantin Mamat
Publikováno v:
ChemistryOpen, Vol 9, Iss 8, Pp 797-805 (2020)
Abstract The treatment of cancer patients with α‐particle‐emitting therapeutics continues to gain in importance and relevance. The range of radiopharmaceutically relevant α‐emitters is limited to a few radionuclides, as stable chelators or ca
Externí odkaz:
https://doaj.org/article/438f32c0cb654ab9b3871122b6845a96
Autor:
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution
Externí odkaz:
https://doaj.org/article/df49b90ff84b43d9acf32897f9f258e4
Autor:
Fabian Krutzek, Cornelius K. Donat, Martin Ullrich, Kristof Zarschler, Marie-Charlotte Ludik, Anja Feldmann, Liliana R. Loureiro, Klaus Kopka, Sven Stadlbauer
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2638
Cancers 15(2023), 2638
Cancers 15(2023), 2638
Noninvasive molecular imaging of the PD-1/PD-L1 immune checkpoint is of high clinical relevance for patient stratification and therapy monitoring in cancer patients. Here we report nine small-molecule PD-L1 radiotracers with solubilizing sulfonic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46211b5531942ab4d43bf4598ab05790
Autor:
Patrick Cieslik, Manja Kubeil, Kristof Zarschler, Martin Ullrich, Florian Brandt, Karl Anger, Hubert Wadepohl, Klaus Kopka, Michael Bachmann, Jens Pietzsch, Holger Stephan, Peter Comba
Publikováno v:
Journal of the American Chemical Society 144(2022)47, 21555-21567
We report a nonadentate bispidine (3,7-diazabicyclo[3.3.1]nonane) that unveils the potential to bind theranostically relevant radionuclides, including indium-111, lutetium-177 and actinium-225 at mild labeling conditions. This radiopharmaceutical can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abeb49cfe69f6fd27607451b901b800
https://pubmed.ncbi.nlm.nih.gov/36382991
https://pubmed.ncbi.nlm.nih.gov/36382991
Autor:
Hua Yang, Chris Orvig, Luke Wharton, Manja Kubeil, Xiaozhu Wang, Holger Stephan, Lily Southcott, Kristof Zarschler, María de Guadalupe Jaraquemada-Peláez, Neha Choudhary, Brian O. Patrick
Publikováno v:
Inorganic Chemistry. 60:12186-12196
A new versatile chelating ligand for intermediate size and softness radiometals [64Cu]Cu2+ and [111In]In3+, H2pyhox, was synthesized by introducing pyridine as a new donor moiety to complement 8-hydroxyquinoline on an ethylenediamine backbone. The co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0722e576664cd29132a5129fdb6bde8
https://doi.org/10.1021/acs.inorgchem.1c01412
https://doi.org/10.1021/acs.inorgchem.1c01412
Autor:
Martin Ullrich, Martin Walther, Hans-Jürgen Pietzsch, Kristof Zarschler, Ian Moore F. Gilpin, Thomas Wünsche, Jens Pietzsch, Ondřej Lebeda
Publikováno v:
Chemmedchem
We show the synthesis of an in vivo stable mercury compound with functionality suitable for radiopharmaceuticals. The designed cyclic bisarylmercury was based on the water tolerance of organomercurials, higher bond dissociation energy of Hg−Ph to H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2878899b39a9130b9d94ddd7e702dcfc
http://europepmc.org/articles/PMC8518081
http://europepmc.org/articles/PMC8518081
Autor:
Adrian Wünsche, Kristof Zarschler, Birgit Belter, Stephan Holger, Klaus Kopka, Jens Pietzsch, Manja Kubeil
Publikováno v:
Nuclear Medicine and Biology. :S74-S75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434e726a6f276d7f675e6485d5441986
https://doi.org/10.1016/s0969-8051(22)02239-9
https://doi.org/10.1016/s0969-8051(22)02239-9
Autor:
Xiaozhu Wang, Holger Stephan, Manja Kubeil, Chris Orvig, Marı A de Guadalupe Jaraquemada-Peláez, Valery Radchenko, Kristof Zarschler, Neha Choudhary
Publikováno v:
Inorganic Chemistry. 59:5728-5741
[44/47Sc]Sc3+, [68Ga]Ga3+, and [111In]In3+ are the three most attractive trivalent smaller radiometalnuclides, offering a wide range of distinct properties (emission energies and types) in the tool...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7c549a76d7b9a242224233c5fd6d1e
https://doi.org/10.1021/acs.inorgchem.0c00509
https://doi.org/10.1021/acs.inorgchem.0c00509
Autor:
Holger Stephan, Garima Singh, Carmen L. Ruehl, Madlen Matterna, Irma Ivette Santana Martínez, Kristof Zarschler, Ralf Bergmann, Michael Bachmann, Peter Comba, Domokos Máthé, Sebastian Hunoldt, Nikolett Hegedüs
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Bifunctional chelators as parts of modular metal‐based radiopharmaceuticals are responsible for stable complexation of the radiometal ion and for covalent linkage between the complex and the targeting vector. To avoid loss of complex stability, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bef2a70dd45f90474c70a8e391e9cf
http://europepmc.org/articles/PMC7028042
http://europepmc.org/articles/PMC7028042
Autor:
Falco Reissig, Kristof Zarschler, Zbynek Novy, Milos Petrik, Katerina Bendova, Daniela Kurfurstova, Jan Bouchal, Marie-Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Jürgen Pietzsch, Marian Hajduch, Constantin Mamat
Publikováno v:
Theranostics 12(2022), 7203-7215
Rationale: Small 225Ac-labeled prostate-specific membrane antigen (PSMA)-targeted radioconjugates have been described for targeted alpha therapy of metastatic castration-resistant prostate cancer. Transient binding to serum albumin as a highly abunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8b8c884205da5c842281f61ee28cb
https://www.hzdr.de/publications/Publ-34927-1
https://www.hzdr.de/publications/Publ-34927-1
