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pro vyhledávání: '"Kristof Stevens"'
Autor:
Kristof Stevens, Annemieke Madder
Publikováno v:
Nucleic Acids Research
Among the various types of DNA damage, inter-strand cross-links (ICL) represent one of the most cytotoxic lesions. Processes such as transcription and replication can be fully blocked by ICLs, as shown by the mechanism of action of some anticancer dr
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(4)
Short oligonucleotides can selectively recognize duplexes by binding in the major groove thereby forming triplexes. Based on the success of our recently developed strategy for furan-based crosslinking in DNA duplexes, we here investigated for the fir
Autor:
Sara Figaroli, Veronique Van Speybroeck, Stefan Schürch, Annemieke Madder, Michal Hocek, Kristof Stevens, Saron Catak, Jan M. Tromp, Diederica D. Claeys
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 17(25)
Oligodeoxynucleotides incorporating a reactive functionality can cause irreversible cross-linking to the target sequence and have been widely studied for their potential in inhibition of gene expression or development of diagnostic probes for gene an
Publikováno v:
Collection Symposium Series.
Autor:
Annemieke Madder, Kristof Stevens
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 26(10-12)
A novel furan containing phosphoramidite was synthesized and incorporated into model oligonucleotides. This glycol nucleic acid based building block contains a furan unit substituting the natural base, and can be used for post synthetic oligonucleoti