Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kristmundur Sigmundsson"'
Autor:
Maharah Mahid, Pradeep Bist, Kristmundur Sigmundsson, Muhammad Danial Mohd Mazlan, Satoru Watanabe, Milly Choy, Subhash Vasudevan, Kitti Chan
Publikováno v:
Bio-Protocol, Vol 14, Iss 20 (2024)
Dengue virus (DENV), a common and prevalent mosquito-borne endemic disease, is caused by four serotypes (DENV-1–4) and has spread rapidly on a global scale over the past decade. A crucial step in the development of antiviral therapeutics requires t
Externí odkaz:
https://doaj.org/article/185f56bbf5f04d00bfc584f5ab08ed3b
Autor:
Danielle E. Anderson, Kristin Pfeffermann, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L. Corcoran, Yvonne Krebs, Kristmundur Sigmundsson, Sharon F. Jamison, Zhen Zhen Joanna Yeo, Linda J. Rennick, Lin-Fa Wang, Pierre J. Talbot, W. Paul Duprex, Mariano A. Garcia-Blanco, Veronika von Messling
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Paramyxoviruses and pneumoviruses have similar life cycles and share the respiratory tract as a point of entry. In comparative genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses in A549 cells,
Externí odkaz:
https://doaj.org/article/458b77fa67604a6a92aa29f115dcdb71
Autor:
Yu Wang, Danielle E. Anderson, So Young Kim, Yefeng Tang, Xu Tan, Kristmundur Sigmundsson, Wenhong Zu, Jin Cui, Jing Gong, Aaron T. Irving, Lin-Fa Wang, Xiao Fang Lim, Biao Guo Yan, Qian Ye, Wenjie Tan, Xuming Zhou, Chao Jiang, Peihua Niu, Haoyu Zhang, Baoying Huang, Ya Tan, Fei Ye, Weiqiang Liu
Publikováno v:
Proc Natl Acad Sci U S A
Bats are responsible for the zoonotic transmission of several major viral diseases, including those leading to the 2003 SARS outbreak and likely the ongoing COVID-19 pandemic. While comparative genomics studies have revealed characteristic adaptation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4952657352adb98475ee67f7f572cff7
https://doi.org/10.1073/pnas.2104759118
https://doi.org/10.1073/pnas.2104759118
Autor:
Johan Flygare, Marcin W. Wlodarski, Fredrik Ek, Jun Chen, Thomas Lundbäck, Kavitha Siva, Abdul Ghani Alattar, Kristmundur Sigmundsson, Roger Olsson
Publikováno v:
SLAS Discovery. 24:304-313
Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce4e855df093eb915b4f0026bbcb898
https://doi.org/10.1177/2472555218823531
https://doi.org/10.1177/2472555218823531
Autor:
David M. Virshup, Chao Liang, Kristmundur Sigmundsson, Gediminas Greicius, Manvendra K. Singh, Ralph M. Bunte, Zahra Kabiri
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Tissue stem cells in vivo reside in highly structured niches that provide signals for proliferation and differentiation. Understanding the role of the niche requires identifying the key cell types that provide these regulators. In the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c161b4ada01add9adf1c8f88f530c6e
http://europepmc.org/articles/PMC5889626
http://europepmc.org/articles/PMC5889626
Autor:
Kristmundur Sigmundsson, Lars Johansson, Ulf Martens, Thomas Helleday, Annika Jenmalm Jensen, Maria Häggblad, Thomas Lundbäck, Bo Lundgren, Olga Loseva, Sabin Llona-Minguez, Ann-Sofie Jemth, Martin Scobie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3219-3225
Two screening campaigns using commercial (Chembridge DiverSET) and proprietary (Chemical Biology Consortium Sweden, CBCS) compound libraries, revealed a number of pyridone- and pyrimidinone-derived systems as inhibitors of the human dCTP pyrophosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732fafcf910631bc9de420df40e9c8ca
https://doi.org/10.1016/j.bmcl.2017.06.039
https://doi.org/10.1016/j.bmcl.2017.06.039
Autor:
Sabin Llona-Minguez, Annika Jenmalm Jensen, Artin Ghassemian, Shabnam Fayezi, José Manuel Calderón-Montaño, André Mateus, Thomas Helleday, Cindy Cazares-Körner, Matthieu Desroses, Elisee Wiita, Masoud Darabi, Pawel Baranczewski, Tobias Koolmeister, Ann-Sofie Jemth, Amir Mehdizadeh, Olga Loseva, Per Artursson, Estefanía Burgos Morón, Martin Scobie, Ulrika Warpman Berglund, Kristmundur Sigmundsson, Evert Homan, Ingrid Almlöf, Nicholas C.K. Valerie, Andreas Höglund, Kumar Sanjiv, Thomas Lundbäck
Publikováno v:
Journal of Medicinal Chemistry. 60:4279-4292
The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce3738fe841b05f7b7f67a3bc6a826d
https://doi.org/10.1021/acs.jmedchem.7b00182
https://doi.org/10.1021/acs.jmedchem.7b00182
Autor:
Kristian Dreij, Karl E. Carlström, Fredrik Piehl, Olle Rengby, Elias S.J. Arnér, Kristmundur Sigmundsson, Katarina Johansson, Marcus Cebula
Publikováno v:
Antioxidants & Redox Signaling. 26:229-246
Many transcription factors with importance in health and disease are redox regulated. However, how their activities may be intertwined in responses to redox-perturbing stimuli is poorly understood. To enable in-depth characterization of this aspect,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24559e0e98bd2354f8f533cb431065d1
https://doi.org/10.1089/ars.2015.6419
https://doi.org/10.1089/ars.2015.6419
Autor:
Kristmundur Sigmundsson, Danielle E. Anderson, So Young Kim, Zhen Zhen Joanna Yeo, Sharon F. Jamison, Kristin Pfeffermann, James L. Pearson, Bevan Sawatsky, Mikhail Kovtun, Lin-Fa Wang, Pierre J. Talbot, Veronika von Messling, Mariano A. Garcia-Blanco, Yvonne Krebs, David L. Corcoran, Linda J. Rennick, W. Paul Duprex
Publikováno v:
mBio
mBio, American Society for Microbiology, 2019, 10 (3), pp.e00826-19. ⟨10.1128/mBio.00826-19⟩
mBio, Vol 10, Iss 3, p e00826-19 (2019)
mBio, Vol 10, Iss 3 (2019)
mBio, American Society for Microbiology, 2019, 10 (3), pp.e00826-19. ⟨10.1128/mBio.00826-19⟩
mBio, Vol 10, Iss 3, p e00826-19 (2019)
mBio, Vol 10, Iss 3 (2019)
International audience; Paramyxoviruses and pneumoviruses have similar life cycles and share the respiratory tract as a point of entry. In comparative genome-scale siRNA screens with wild-type-derived measles, mumps, and respiratory syncytial viruses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c171b55fefea4bac328314cbb65f0d02
https://doi.org/10.1128/mbio.00826-19
https://doi.org/10.1128/mbio.00826-19
Autor:
Georges Vauquelin, Mats Larhed, Vivek Konda, Hanna Axelsson, Ulrika Rosenström, Annika Jenmalm Jensen, Kristmundur Sigmundsson, Karin Engen, Leif Dahllund, Thomas Lundbäck, Magdalena Otrocka, Mathias Hallberg, Alexandros Nikolaou
Publikováno v:
ASSAY and Drug Development Technologies. 14:180-193
Intracerebroventricular injection of angiotensin IV, a ligand of insulin-regulated aminopeptidase (IRAP), has been shown to improve cognitive functions in several animal models. Consequently, IRAP is considered a potential target for treatment of cog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a018e37f38182fd84f9d89c86ef893e0
https://doi.org/10.1089/adt.2016.708
https://doi.org/10.1089/adt.2016.708