Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristine Sponheim"'
Autor:
Axel Berg-Larsen, Anne Mobergslien, Ingrid Moen, Gebregziabher Petros, Alexander Kristian, Kristine Sponheim Gunvaldsen, Véronique Cruciani, Katrine Wickstroem, Roger Malerbakken Bjerke, Jenny Karlsson, Alan Cuthbertson
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Targeted thorium-227 conjugates comprise the combination of a monoclonal antibody with specificity for a tumor cell antigen and a 3,2-HOPO chelator enabling complexation of thorium-227 (Th-227). The radiolabeled conjugate functions as an effective de
Externí odkaz:
https://doaj.org/article/35a8807e6b7b47ed8e2cafef073f9330
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
The clinical efficacy of the first approved alpha pharmaceutical, Xofigo (radium-223 dichloride, 223RaCl2), has stimulated significant interest in the development of new alpha-particle emitting drugs in oncology. Unlike radium-223 (223Ra), the parent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e35ca4b99143e9db09cefc4dfb3643
https://doi.org/10.1158/1535-7163.c.6537598.v1
https://doi.org/10.1158/1535-7163.c.6537598.v1
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Blood samples from animals treated with vehicle and CD33-TTC, administered at the different dose levels, were taken at Day -1, Day 67 and Day 123. (A) White blood cell counts, expressed in 109/L. (B) Red blood cell counts, expressed in 1012/L.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e61add3f7aa0bbca94cc30520932a5
https://doi.org/10.1158/1535-7163.22504039.v1
https://doi.org/10.1158/1535-7163.22504039.v1
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361388845c3296c2208652b4c5f1bd17
https://doi.org/10.1158/1535-7163.22504033
https://doi.org/10.1158/1535-7163.22504033
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Thorium-227 is purified from actinium-227 (227Ac). Thorium-227 decays via its alpha- and beta-emitting daughters to stable nonradioactive 207Pb. The energy emitted at each decay step (in MeV) are summarized. When thorium-227 decays to radium-223, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f22fb266f9a191731b0ff6f2d053ec
https://doi.org/10.1158/1535-7163.22504045
https://doi.org/10.1158/1535-7163.22504045
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Isolated kidneys (A, B) and bone marrow (C, D) were co-stained with a CD33-specific antibody (A, C) and a CD45-specific antibody (B, D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208fb2fc7d4c3690db8486abc7ecb072
https://doi.org/10.1158/1535-7163.22504036
https://doi.org/10.1158/1535-7163.22504036
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Binding of CD33 antibody and CD33 antibody chelator-conjugate to CD33-positive HL-60 cells by FACS staining in comparison to an isotype control. Bound antibodies were detected using secondary PE-labeled anti-human antibody. Median fluorescence intens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86281a6228865dcc88f6a91470e14717
https://doi.org/10.1158/1535-7163.22504042
https://doi.org/10.1158/1535-7163.22504042
Akademický článek
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Autor:
Kristine Sponheim, Jenny Karlsson, Katrine Wickstroem, Ellen Wang, Adam O. Shea, Urs B. Hagemann, Alan Cuthbertson, Roger M. Bjerke, Olav B. Ryan
Publikováno v:
Molecular Cancer Therapeutics. 15:2422-2431
The clinical efficacy of the first approved alpha pharmaceutical, Xofigo (radium-223 dichloride, 223RaCl2), has stimulated significant interest in the development of new alpha-particle emitting drugs in oncology. Unlike radium-223 (223Ra), the parent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46f30709a568b018fef0a8e9de0ec23
https://doi.org/10.1158/1535-7163.mct-16-0251
https://doi.org/10.1158/1535-7163.mct-16-0251
Autor:
Øyvind S. Bruland, Camilla S. Mollatt, Helen Heyerdahl, Jostein Dahle, Nasir Abbas, Kristine Sponheim
Publikováno v:
Scopus-Elsevier
The aim of the current study was to investigate the therapeutic effect of 227Th-radioimmunotherapy on intraperitoneally growing human bioluminescent HER2 positive ovarian cancer cells. Methods: In vitro toxicity of 227Th-trastuzumab in bioluminescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9c99b68dcea884ceb73dd5d2841209
https://pubmed.ncbi.nlm.nih.gov/23551111
https://pubmed.ncbi.nlm.nih.gov/23551111