The DANish randomized, double-blind, placebo controlled trial in patients with chronic HEART failure (DANHEART): A 2 x 2 factorial trial of hydralazine-isosorbide dinitrate in patients with chronic heart failure (H-HeFT) and metformin in patients with chronic heart failure and diabetes or prediabetes (met-HeFT)☆

Autor: Kiomars Mahboubi, Jens Brønnum-Schou, Jacob E. Møller, Jawdat Abdulla, Christian Torp-Petersen, Henrik Wiggers, Gitte Nielsen, Anders Hostrup Larsen, Karen Kaae Dodt, Anne Sejr Knudsen, Søren Lund Kristensen, Jens Lomholdt, Christian Hassager, Helene Nørrelund, Dan Eik Høfsten, Vibeke Brogaard Hansen, Søren Vraa, Hans Eiskjær, Søren Mellemkjær, Lars Køber, Malene Hollingdal, Ilan Raymond, O.W. Nielsen, Kristine Serup-Hansen, Jens Christian Refsgaard, Kirsten Vilain Mikkelsen, Anders Barasa, Niels Eske Bruun, Hans Erik Bøtker, Bo Martin Bibby, Finn Gustafsson, Morten Schou, Morten Bøttcher, Gunnar Gislason, Bartlomiej Jonczy, Jette Sandberg Madsen, Flemming Hald Steffensen, Monica Petronela Poenaru, Karen Sillesen, Mikael Kjær Poulsen

Publikováno v: American Heart Journal
Wiggers, H, Køber, L, Gislason, G, Schou, M, Poulsen, M K, Vraa, S, Nielsen, O W, Bruun, N E, Nørrelund, H, Hollingdal, M, Barasa, A, Bøttcher, M, Dodt, K, Hansen, V B, Nielsen, G, Knudsen, A S, Lomholdt, J, Mikkelsen, K V, Jonczy, B, Brønnum-Schou, J, Poenaru, M P, Abdulla, J, Raymond, I, Mahboubi, K, Sillesen, K, Serup-Hansen, K, Madsen, J S, Kristensen, S L, Larsen, A H, Bøtker, H E, Torp-Petersen, C, Eiskjær, H, Møller, J, Hassager, C, Steffensen, F H, Bibby, B M, Refsgaard, J, Høfsten, D E, Mellemkjær, S & Gustafsson, F 2021, ' The DANish randomized, double-blind, placebo controlled trial in patients with chronic HEART failure (DANHEART) : A 2 × 2 factorial trial of hydralazine-isosorbide dinitrate in patients with chronic heart failure (H-HeFT) and metformin in patients with chronic heart failure and diabetes or prediabetes (Met-HeFT) ', American Heart Journal, vol. 231, pp. 137-146 . https://doi.org/10.1016/j.ahj.2020.09.020
Wiggers, H, Køber, L, Gislason, G, Schou, M, Poulsen, M K, Vraa, S, Nielsen, O W, Bruun, N E, Nørrelund, H, Hollingdal, M, Barasa, A, Bøttcher, M, Dodt, K, Hansen, V B, Nielsen, G, Knudsen, A S, Lomholdt, J, Mikkelsen, K V, Jonczy, B, Brønnum-Schou, J, Poenaru, M P, Abdulla, J, Raymond, I, Mahboubi, K, Sillesen, K, Serup-Hansen, K, Madsen, J S, Kristensen, S L, Larsen, A H, Bøtker, H E, Torp-Petersen, C, Eiskjær, H, Møller, J, Hassager, C, Steffensen, F H, Bibby, B M, Refsgaard, J, Høfsten, D E, Mellemkjær, S & Gustafsson, F 2021, ' The DANish randomized, double-blind, placebo controlled trial in patients with chronic HEART failure (DANHEART) : A 2 × 2 factorial trial of hydralazine-isosorbide dinitrate in patients with chronic heart failure (H-HeFT) and metformin in patients with chronic heart failure and diabetes or prediabetes (Met-HeFT) ', American Heart Journal, vol. 231, pp. 137-146 . https://doi.org/10.1016/j.ahj.2020.09.020, https://doi.org/10.1016/j.ahj.2020.09.020

OBJECTIVES: The DANHEART trial is a multicenter, randomized (1:1), parallel-group, double-blind, placebo-controlled study in chronic heart failure patients with reduced ejection fraction (HFrEF). This investigator driven study will include 1500 HFrEF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1e160357c3400540d64d48cbe0cd8c
http://europepmc.org/articles/PMC7544566