Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristine S Ojala"'
Autor:
Kristine S Ojala, Cassandra J Kaufhold, Mykenzie R Davey, Donggyun Yang, Mary Liang, Peter Wipf, Yomna Badawi, Stephen D Meriney
Publikováno v:
Human Molecular Genetics. 32:1901-1911
Spinal muscular atrophy (SMA) is a monogenic disease that clinically manifests as severe muscle weakness owing to neurotransmission defects and motoneuron degeneration. Individuals affected by SMA experience neuromuscular weakness that impacts functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d4f5e4be897d59a49af15be06bee41
https://doi.org/10.1093/hmg/ddad019
https://doi.org/10.1093/hmg/ddad019
Publikováno v:
Brain Sciences, Vol 11, Iss 2, p 194 (2021)
Until the recent development of disease-modifying therapeutics, spinal muscular atrophy (SMA) was considered a devastating neuromuscular disease with a poor prognosis for most affected individuals. Symptoms generally present during early childhood an
Externí odkaz:
https://doaj.org/article/be9d3013b22f4c5c97cab4b558a6a0c9
Autor:
Stephen D. Meriney, Manuel Covarrubias, Gloria Ortiz, Evan W. Miller, Scott P. Ginebaugh, Kristine S. Ojala, Man Wu
Publikováno v:
The Journal of Biological Chemistry
3,4-Diaminopyridine (3,4-DAP) increases transmitter release from neuromuscular junctions (NMJs), and low doses of 3,4-DAP (estimated to reach ∼1 μM in serum) are the Food and Drug Administration (FDA)-approved treatment for neuromuscular weakness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbc3cf8e9a87415c7993f465b092f47
https://pubmed.ncbi.nlm.nih.gov/33465376
https://pubmed.ncbi.nlm.nih.gov/33465376
Autor:
Stephen D. Meriney, Adolfo Garcia-Ocaña, Man Wu, Mary Liang, Yizhi Li, Tyler B. Tarr, Guillermo Valdomir, Peter Wipf, David Lacomis, Kristine S. Ojala
Publikováno v:
Annals of the New York Academy of Sciences. 1412:73-81
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder caused by antibodies directed against the voltage-gated calcium channels that provide the calcium ion flux that triggers acetylcholine release at the neuromuscular junction. To study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817771d960f6413e8b0a23f80fbc364a
https://doi.org/10.1111/nyas.13512
https://doi.org/10.1111/nyas.13512
Publikováno v:
Brain Sciences, Vol 11, Iss 194, p 194 (2021)
Brain Sciences
Brain Sciences
Until the recent development of disease-modifying therapeutics, spinal muscular atrophy (SMA) was considered a devastating neuromuscular disease with a poor prognosis for most affected individuals. Symptoms generally present during early childhood an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6210836d54a82f377411a605b2165f0
https://doi.org/10.3390/brainsci11020194
https://doi.org/10.3390/brainsci11020194