T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

Autor: Aida S. Hansen, Lea S. Jensen, Kristine R. Gammelgaard, Kristoffer G. Ryttersgaard, Christian Krapp, Jesper Just, Kasper L. Jønsson, Pia B. Jensen, Thomas Boesen, Mogens Johannsen, Anders Etzerodt, Bent W. Deleuran, Martin R. Jakobsen

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 8, Pp n/a-n/a (2023)

Abstract A key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumour recognition and hence hereof tumour eradication, the majori

Externí odkaz: https://doaj.org/article/243433d9b85349ca81ff3bd193a23e6f

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection

Autor: Renée M van der Sluis, Lamin B Cham, Albert Gris‐Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Manja Idorn, Ulvi Ahmadov, Sabina Sanches Hernandez, Ena Cémalovic, Stine H Godsk, Jacob Thyrsted, Jesper D Gunst, Silke D Nielsen, Janni J Jørgensen, Tobias Wang Bjerg, Anders Laustsen, Line S Reinert, David Olagnier, Rasmus O Bak, Mads Kjolby, Christian K Holm, Martin Tolstrup, Søren R Paludan, Lasse S Kristensen, Ole S Søgaard, Martin R Jakobsen

Publikováno v: van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Sanches Hernandez, S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Wang Bjerg, T, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', The EMBO Journal, pp. e109622 . https://doi.org/10.15252/embj.2021109622
van der Sluis, R M, Cham, L B, Gris-Oliver, A, Gammelgaard, K R, Pedersen, J G, Idorn, M, Ahmadov, U, Hernandez, S S, Cémalovic, E, Godsk, S H, Thyrsted, J, Gunst, J D, Nielsen, S D, Jørgensen, J J, Bjerg, T W, Laustsen, A, Reinert, L S, Olagnier, D, Bak, R O, Kjolby, M, Holm, C K, Tolstrup, M, Paludan, S R, Kristensen, L S, Søgaard, O S & Jakobsen, M R 2022, ' TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection ', EMBO Journal, vol. 41, no. 10, e109622 . https://doi.org/10.15252/embj.2021109622

Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infection is critical for developing treatments for severe COVID-19. Here, we find decreasing number of circulating plasmacytoid dendritic cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fd30736af2a491a85fdee063fc4b93
https://doi.org/10.15252/embj.2021109622

T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy.

Autor: Hansen, Aida S.¹ (AUTHOR) aida@biomed.au.dk, Jensen, Lea S.¹ (AUTHOR), Gammelgaard, Kristine R.¹ (AUTHOR), Ryttersgaard, Kristoffer G.¹ (AUTHOR), Krapp, Christian¹ (AUTHOR), Just, Jesper² (AUTHOR), Jønsson, Kasper L.¹ (AUTHOR), Jensen, Pia B.³ (AUTHOR), Boesen, Thomas³ (AUTHOR), Johansen, Mogens⁴ (AUTHOR), Etzerodt, Anders¹ (AUTHOR), Deleuran, Bent W.¹ (AUTHOR), Jakobsen, Martin R.¹ (AUTHOR) mrj@biomed.au.dk

Publikováno v: Journal of Extracellular Vesicles. Aug2023, Vol. 12 Issue 8, p1-17. 17p.