Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Kristine Pelton"'
Autor:
Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, Juliann Shih, Shu Zhang, Noah F. Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G. Miller, Alexandra L. Condurat, Elizabeth M. Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E. Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E. Guerra Garcia, Claire E. Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S. Persky, David E. Root, Angel M. Carcaboso, Benjamin L. Ebert, Christine Fuller, Ozgun Babur, Mark W. Kieran, Chris Jones, Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of
Externí odkaz:
https://doaj.org/article/05d88dcae9c94b0ba00bbf84c4d8c770
Autor:
Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
Externí odkaz:
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd
Autor:
Robert J. Kimmerling, Sanjay M. Prakadan, Alejandro J. Gupta, Nicholas L. Calistri, Mark M. Stevens, Selim Olcum, Nathan Cermak, Riley S. Drake, Kristine Pelton, Frederik De Smet, Keith L. Ligon, Alex K. Shalek, Scott R. Manalis
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Mass and growth rate are highly integrative measures of cell physiology not discernable via genomic measurements. Here, we introduce a microfluidic platform enabling direct measurement of single-cell mass and growth rate upstream of highly m
Externí odkaz:
https://doaj.org/article/e86b5438fb3e4a98ad23b6bf3b2b5f02
Autor:
Jayoung Kim, Dolores Di Vizio, Taek-Kyun Kim, Jonghwan Kim, Minjung Kim, Kristine Pelton, Steven K. Clinton, Tsonwin Hai, Daehee Hwang, Keith R. Solomon, Michael R. Freeman
Publikováno v:
PLoS ONE, Vol 7, Iss 8 (2012)
Externí odkaz:
https://doaj.org/article/bd8b094d463f4e55aa3cbc99725c6961
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30062 (2012)
Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence of gonadal androgens, termed
Externí odkaz:
https://doaj.org/article/a64edf3aa83645b8ad0255a8a57495ea
Autor:
Jayoung Kim, Dolores Di Vizio, Taek-Kyun Kim, Jonghwan Kim, Minjung Kim, Kristine Pelton, Steven K Clinton, Tsonwin Hai, Daehee Hwang, Keith R Solomon, Michael R Freeman
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39448 (2012)
Elevated circulating cholesterol is a systemic risk factor for cardiovascular disease and metabolic syndrome, however the manner in which the normal prostate responds to variations in cholesterol levels is poorly understood. In this study we addresse
Externí odkaz:
https://doaj.org/article/2402e3ea0ded4aaea2ccce918964b9c3
Autor:
Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, Jared K. Woods, Shakti Ramkissoon, Lori Ramkissoon, Frank Dubois, Kathleen Schoolcraft, Jessica Tsai, Dayle Wang, Robert Jones, Jayne Vogelzang, Kristine Pelton, Sarah Becker, Fiona Watkinson, Claire Sinai, Elizabeth F. Cohen, Matthew A. Booker, Michael Y. Tolstorukov, Veerle Haemels, Liliana Goumnerova, Karen Wright, Mark Kieran, Katie Fehnel, David Reardon, Arnault Tauziede-Espariat, Rishi Lulla, Benjamin Carcamo, Stanley Chaleff, Alain Charest, Frederik De Smet, Azra H. Ligon, Adrian Dubuc, Melanie Pages, Pascale Varlet, Patrick Y. Wen, Brian M. Alexander, Susan Chi, Sanda Alexandrescu, Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon
Publikováno v:
Clinical Cancer Research. :OF1-OF17
Purpose: Anaplastic lymphoma kinase (ALK) aberrations have been identified in pediatric-type infant gliomas, but their occurrence across age groups, functional effects, and treatment response has not been broadly established. Experimental Design: We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284b9c146f0dfa3d1d6edc1c4f96c9f1
https://doi.org/10.1158/1078-0432.ccr-21-3521
https://doi.org/10.1158/1078-0432.ccr-21-3521
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 3: PPP1CB-ALK fusion is oncogenic and sensitive to targeted therapy. A. Immunoblot analysis of ALK downstream signaling proteins in cortical mNSC (CTX#6) and brainstem mNSC (BS#3) expressing PPP1CB-ALK. Cells were treated for 4 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6f55cc812f188c30f166cd96a721a2
https://doi.org/10.1158/1078-0432.22490657
https://doi.org/10.1158/1078-0432.22490657
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67179e7baac4cc1baaf982962c9e364e
https://doi.org/10.1158/1078-0432.22490648
https://doi.org/10.1158/1078-0432.22490648
Autor:
Keith L. Ligon, Rameen Beroukhim, Pratiti Bandopadhayay, Robert Bachoo, Ralf Kittler, Sanda Alexandrescu, Susan Chi, Brian M. Alexander, Patrick Y. Wen, Pascale Varlet, Melanie Pages, Adrian Dubuc, Azra H. Ligon, Frederik De Smet, Alain Charest, Stanley Chaleff, Benjamin Carcamo, Rishi Lulla, Arnault Tauziede-Espariat, David Reardon, Katie Fehnel, Mark Kieran, Karen Wright, Liliana Goumnerova, Veerle Haemels, Michael Y. Tolstorukov, Matthew A. Booker, Elizabeth F. Cohen, Claire Sinai, Fiona Watkinson, Sarah Becker, Kristine Pelton, Jayne Vogelzang, Robert Jones, Dayle Wang, Jessica Tsai, Kathleen Schoolcraft, Frank Dubois, Lori Ramkissoon, Shakti Ramkissoon, Jared K. Woods, Seth Malinowski, Guadalupe Garcia, Maya Srikanth Graham, Ross Giglio, Anne-Florence Blandin
Purpose:Anaplastic lymphoma kinase (ALK) aberrations have been identified in pediatric-type infant gliomas, but their occurrence across age groups, functional effects, and treatment response has not been broadly established.Experimental Design:We per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6831c03b61aab5d2915a36779f74d458
https://doi.org/10.1158/1078-0432.c.6533192
https://doi.org/10.1158/1078-0432.c.6533192