Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristine N Wright"'
Autor:
Kathy A. Aldern, Douglas D. Richman, Ganesh D. Kini, James R. Beadle, Michael F. Gardner, Karl Y. Hostetler, Kristine N. Wright
Publikováno v:
Antiviral Chemistry and Chemotherapy. 9:33-40
In a previous study, we reported that 1- O-octadecyl- sn-glycero-3-foscarnet (ODG-PFA) was 40 to 93 times more potent than free foscarnet (PFA) in human cytomegalovirus (HCMV)-, herpes simplex virus type 1 (HSV-1)- and human immunodeficiency virus ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c4513ee9dbfafdf8fd1df480e7e860
https://doi.org/10.1177/095632029800900104
https://doi.org/10.1177/095632029800900104
Autor:
Kristine N. Wright, Brent A. Korba, James R. Beadle, Ganesh D. Kini, Michael F. Gardner, Karl Y. Hostetler, Tong-Hau Wu
Publikováno v:
Biochemical Pharmacology. 53:1815-1822
Acyclovir (ACV) triphosphate and azidothymidine (AZT) triphosphate inhibit the DNA polymerase of human hepatitis B virus (HBV) by 50% at submicromolar concentrations, but no effects of ACV or AZT treatment have been noted on the clinical manifestatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f0282f085942e0ddc1b7d7be99e69f
https://doi.org/10.1016/s0006-2952(97)82446-x
https://doi.org/10.1016/s0006-2952(97)82446-x
Autor:
Ganesh D. Kini, Kathy A. Aldern, Kristine N. Wright, Rachel J. Rybak, Earl R. Kern, Michael F. Gardner, Karl Y. Hostetler, James R. Beadle
Publikováno v:
ChemInform. 31
We synthesized, 1-O-hexadecylpropanediol-3–P-acyclovir, an orally bioavailable lipid prodrug of acyclovir and evaluated it for in vitro and in vivo activity against herpes simplex virus infections. Although 1-O-hexadecylpropanediol-3–P-acyclovir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b958e09df8539389a9ae1daa552bb82
https://doi.org/10.1002/chin.200029200
https://doi.org/10.1002/chin.200029200
Purpose To determine the effect of molecular size on the drainage route of dextrans injected into the rat anterior chamber (AC). Methods Anesthetized adult rats received monocular AC injections of a mixture of 3-kDa dextran-cascade blue, 40-kDa dextr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf43f08b8150bdb52399b38f7ac9537
https://europepmc.org/articles/PMC5672831/
https://europepmc.org/articles/PMC5672831/
Autor:
Michael F. Gardner, Karl Y. Hostetler, Kristine N. Wright, James R. Beadle, Earl R. Kern, Ganesh D. Kini, Kathy A. Aldern, Rachel J. Rybak
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 19(1-2)
We synthesized, 1-O-hexadecylpropanediol-3–P-acyclovir, an orally bioavailable lipid prodrug of acyclovir and evaluated it for in vitro and in vivo activity against herpes simplex virus infections. Although 1-O-hexadecylpropanediol-3–P-acyclovir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ee236b28dfa91ab2b1dbe123b28245
https://pubmed.ncbi.nlm.nih.gov/10772728
https://pubmed.ncbi.nlm.nih.gov/10772728