A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug

Autor: Philip F. Copenhaver, Thimmappa S. Anekonda, Derek Musashe, Kristine M. Robinson, Jenna M. Ramaker, Tracy L. Swanson, Teri L. Wadsworth, Doris Kretzschmar, Randall L. Woltjer, Joseph F. Quinn

Publikováno v: Disease Models & Mechanisms, Vol 4, Iss 5, Pp 634-648 (2011)

SUMMARY A growing body of evidence supports the ‘calcium hypothesis’ of Alzheimer’s disease (AD), which postulates that a variety of insults might disrupt the homeostatic regulation of neuronal calcium (Ca2+) in the brain, resulting in the prog

Externí odkaz: https://doaj.org/article/f3342a8f76b14e7092495bbbacfb9461

The selective detection of mitochondrial superoxide by live cell imaging

Autor: Kristine M. Robinson, Joseph S. Beckman, Michael S. Janes

Publikováno v: Nature Protocols. 3:941-947

A general protocol is described to improve the specificity for imaging superoxide formation in live cells via fluorescence microscopy with either hydroethidine (HE) or its mitochondrially targeted derivative Mito-HE (MitoSOX Red). Two different excit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b0147b3306d181be09b2893ca5a3ec
https://doi.org/10.1038/nprot.2008.56

Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons

Autor: Joseph S. Beckman, Pedro M. Alzari, Kristine M. Robinson, Patrick England, Patricia Cassina, Luis Barbeito, Mariana Pehar, Marcelo R. Vargas

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2006, 41 (11), pp.1632-1644. ⟨10.1016/j.freeradbiomed.2006.08.010⟩
Free Radical Biology and Medicine, 2006, 41 (11), pp.1632-1644. ⟨10.1016/j.freeradbiomed.2006.08.010⟩

International audience; Nerve growth factor (NGF) overexpression and increased production of peroxynitrite occur in several neurodegenerative diseases. We investigated whether NGF could undergo posttranslational oxidative or nitrative modifications t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c3e2fe3908ddf88570629f357d2c97
https://doi.org/10.1016/j.freeradbiomed.2006.08.010

Triuret: a novel product of peroxynitrite-mediated oxidation of urate

Autor: Kristine M. Robinson, Joseph S. Beckman, Jeffrey T. Morré

Publikováno v: Archives of Biochemistry and Biophysics. 423:213-217

Urate is an efficient antioxidant and has recently emerged as a competitive inhibitor of tyrosine nitration by peroxynitrite. In vivo and in vitro studies demonstrate the large extent to which urate prevents nitration and establish the biological imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f8d967f3e1ac513aafab37d8125e3d
https://doi.org/10.1016/j.abb.2003.10.011

Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides

Autor: Stephen Barnes, Amy L. Strayer, Karina C. Ricart, Celia Quijano, Mary Anne Sahawneh, Marion Kirk, Kristine M. Robinson, Mary Ann Accavitti-Loper, Joseph S. Beckman, Yaozu Ye, Rafael Radi, John J. Shacka, Alvaro G. Estévez

Publikováno v: The Journal of biological chemistry. 282(9)

Although peroxynitrite stimulates apoptosis in many cell types, whether peroxynitrite acts directly as an oxidant or the induction of apoptosis is because of the radicals derived from peroxynitrite decomposition remains unknown. Before undergoing apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5263cde6108c17fd05bc4370afcdfdbe
https://pubmed.ncbi.nlm.nih.gov/17200124