Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristine M. Muller"'
Autor:
Min Wong, Yang Xu, Scot Middleton, Matthew R. Lee, Anu Gore, Mike Fiorino, Alex Pickrell, Kristine M. Muller, Andrea Itano, Mike Frohn, Heather A. Arnett, Janet Buys, Michelle Horner, Dalia Rivenzon-Segal, Jennifer E. Golden, Victor J. Cee, Hugo M. Vargas, Roland Burli, Susana C. Neira, Michael Schrag, Han Xu, Brian A. Lanman, Michele McElvain, Xuxia Zhang, Jerry Siu
Publikováno v:
ACS Medicinal Chemistry Letters. 2:107-112
The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469aac7dbf0531b12b4eec83f252b55d
https://doi.org/10.1021/ml100306h
https://doi.org/10.1021/ml100306h
Autor:
Jennifer E. Golden, Randall W. Hungate, Alexander J. Pickrell, Gloria Biddlecome, Roland Burli, Mike Frohn, Jennifer Dao, Norma Rogers, Vellarkad N. Viswanadhan, Jennifer R. Allen, Kristine M. Muller, Sean Yoder
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5023-5026
We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe8ee6a4b24c934b0f90897c408cc8
https://doi.org/10.1016/j.bmcl.2008.08.012
https://doi.org/10.1016/j.bmcl.2008.08.012
Publikováno v:
Tetrahedron Letters. 49:794-798
The regioselective, copper-catalyzed coupling of a tautomeric pyrazolone/pyrazole with 2-halopyridines was investigated. Conditions were developed to preferentially form either the N-aryl or O-aryl product.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20de58f596f180be7b399be54df34465
https://doi.org/10.1016/j.tetlet.2007.11.185
https://doi.org/10.1016/j.tetlet.2007.11.185
Autor:
Kelly Regal, Randall W. Hungate, Mike Frohn, Vellarkad N. Viswanadhan, Matthew Adlam, Han Xu, Philip Tagari, Min Wong, Kristine M. Muller, Roland Burli, Jennifer E. Golden, Xiaoming Zou, Matthew H. Plant, Michele McElvain
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3713-3718
We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19e4048cb68caaf96dd2c0a6c5b8b6a
https://doi.org/10.1016/j.bmcl.2006.04.068
https://doi.org/10.1016/j.bmcl.2006.04.068
Autor:
Brian A. Keay, Kristine M. Muller
Publikováno v:
Synlett. 2008:1236-1238
An eight-step regiospecific synthesis of the C and D rings of viridin is reported using an intramolecular Diels-Alder reaction of a furan diene as the key step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c57cc97cc4739b4c03ca545e4d78a8ad
https://doi.org/10.1055/s-2008-1072651
https://doi.org/10.1055/s-2008-1072651
Autor:
Michelle Horner, Kristine M. Muller, Xuxia Zhang, Xiang Yu, Nili Schutz, Jerry Siu, Dalia Rivenzon-Segal, Roland Burli, Zhang Zhaoda, Susana C. Neira, Hugo M. Vargas, Alexander J. Pickrell, Jennifer E. Golden, Yang Xu, Victor J. Cee, Michael Schrag, Scot Middleton, Jian Lin, Yael Marantz, Andrea Itano, Mercedes Lobera, Han Xu, Brian A. Lanman, Michele McElvain, Janet Buys, Anu Gore, Srinivasa R Cheruku, Anurag Sharadendu, Mike Fiorino, Mike Frohn
Optimization of a benzofuranyl S1P1 agonist lead compound (3) led to the discovery of 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (14), a potent S1P1 agonist with minimal activity at S1P3. Dosed orally at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4114b66ba763963fd644e7ff1f508317
https://europepmc.org/articles/PMC4018108/
https://europepmc.org/articles/PMC4018108/
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18deceffb7797cc8026f9b4d25f53363
https://doi.org/10.1002/chin.200820109
https://doi.org/10.1002/chin.200820109