Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kristine Langthaler"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo Kp,uu,brain estimates are the gold standard for investigating brain drug disposition, animal usage is a
Externí odkaz:
https://doaj.org/article/335b4fcb2320446ba12246e0fb8eecc1
Autor:
Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Sarah Christine Christensen, Elisabeth Helena Bruun, Birger Brodin, Morten S. Nielsen
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important knowledge gap within maintenan
Externí odkaz:
https://doaj.org/article/19b7d12e1ec14ff993d47e4deb7c4783
Autor:
Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Sarah Christine Christensen, Elisabeth Helena Bruun, Birger Brodin, Morten S. Nielsen
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/cb47c09022c14128b021dc70e4145a71
Publikováno v:
Data in Brief, Vol 16, Iss , Pp 655-659 (2018)
The presented data are related to the research article entitled “Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates” by Ozgur et al. (2017) [1]. This data report describes the challenges of inve
Externí odkaz:
https://doaj.org/article/9373e15bd3814f808453a31f1f3d328c
Autor:
Elin, Eneberg, Christopher R, Jones, Thomas, Jensen, Kristine, Langthaler, Christoffer, Bundgaard
Publikováno v:
Drug Metabolism and Bioanalysis Letters. 15:12-21
Background & Objective: Compound X is a drug candidate for the treatment of neurodegenerative diseases. Its brain distribution was evaluated as part of the lead identification and optimization activities undertaken in early drug discovery. Methods: T
Autor:
Kristine, Langthaler, Christopher R, Jones, Rasmus B, Christensen, Elin, Eneberg, Birger, Brodin, Christoffer, Bundgaard
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 52(6)
The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate
Autor:
Kristine Langthaler, Christopher R. Jones, Rasmus B. Christensen, Elin Eneberg, Birger Brodin, Christoffer Bundgaard
Publikováno v:
Langthaler, K, Jones, C R, Christensen, R B, Eneberg, E, Brodin, B & Bundgaard, C 2022, ' Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies ', Xenobiotica, vol. 52, no. 6, pp. 591-607 . https://doi.org/10.1080/00498254.2022.2115425
1. The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate in vitro to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9a985090dc52f86a8ea6da97f6ab96
https://curis.ku.dk/portal/da/publications/characterisation-of-intravenous-pharmacokinetics-in-goettingen-minipig-and-clearance-prediction-using-established-in-vitro-to-in-vivo-extrapolation-methodologies(04651409-04f2-4166-9cde-13f0f77f14d0).html
https://curis.ku.dk/portal/da/publications/characterisation-of-intravenous-pharmacokinetics-in-goettingen-minipig-and-clearance-prediction-using-established-in-vitro-to-in-vivo-extrapolation-methodologies(04651409-04f2-4166-9cde-13f0f77f14d0).html
Autor:
Lassina Badolo, Burak Ozgür, Kristine Langthaler, Dino Montanari, Anne-Marie Jacobsen, Elin Eneberg, Christian Janfelt, Birger Brodin, Lasse Saaby
Publikováno v:
Ozgür, B, Saaby, L, Janfelt, C, Langthaler, K, Eneberg, E, Jacobsen, A-M, Badolo, L, Montanari, D & Larsen, B B 2021, ' Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp : In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 169, pp. 211-219 . https://doi.org/10.1016/j.ejpb.2021.10.006
Drug efflux by P-glycoprotein (P-gp, ABCB1) is considered as a major obstacle for brain drug delivery for small molecules. P-gp-expressing cell monolayers are used for screening of new drug candidates during early states of drug development. It is, h