Výsledky vyhledávání - "Kristine L. Trotta"

Akademický článek

Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms

Autor: Gabriel Mitchell, Melanie R. Silvis, Kelsey C. Talkington, Jonathan M. Budzik, Claire E. Dodd, Justin M. Paluba, Erika A. Oki, Kristine L. Trotta, Daniel J. Licht, David Jimenez-Morales, Seemay Chou, Paul B. Savage, Carol A. Gross, Michael A. Marletta, Jeffery S. Cox

Publikováno v: mBio, Vol 13, Iss 1 (2022)

ABSTRACT Ceragenins are a family of synthetic amphipathic molecules designed to mimic the properties of naturally occurring cationic antimicrobial peptides (CAMPs). Although ceragenins have potent antimicrobial activity, whether their mode of action

Externí odkaz: https://doaj.org/article/c512a6f1711441e98f090af88a26431e

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Akademický článek

Comprehensive RNA Polymerase II Interactomes Reveal Distinct and Varied Roles for Each Phospho-CTD Residue

Autor: Kevin M. Harlen, Kristine L. Trotta, Erin E. Smith, Mohammad M. Mosaheb, Stephen M. Fuchs, L. Stirling Churchman

Publikováno v: Cell Reports, Vol 15, Iss 10, Pp 2147-2158 (2016)

Transcription controls splicing and other gene regulatory processes, yet mechanisms remain obscure due to our fragmented knowledge of the molecular connections between the dynamically phosphorylated RNA polymerase II (Pol II) C-terminal domain (CTD)

Externí odkaz: https://doaj.org/article/1dabfdeb9f0e41caa4a93ad2a6832f61

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Akademický článek

Lipopolysaccharide transport regulates bacterial sensitivity to a cell wall-degrading intermicrobial toxin.

Autor: Kristine L Trotta, Beth M Hayes, Johannes P Schneider, Jing Wang, Horia Todor, Patrick Rockefeller Grimes, Ziyi Zhao, William L Hatleberg, Melanie R Silvis, Rachel Kim, Byoung Mo Koo, Marek Basler, Seemay Chou

Publikováno v: PLoS Pathogens, Vol 19, Iss 6, p e1011454 (2023)

Gram-negative bacteria can antagonize neighboring microbes using a type VI secretion system (T6SS) to deliver toxins that target different essential cellular features. Despite the conserved nature of these targets, T6SS potency can vary across recipi

Externí odkaz: https://doaj.org/article/74bedf1958784e718ff4720b9a8dfd19

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Akademický článek

Transcription elongation is finely tuned by dozens of regulatory factors

Autor: Mary Couvillion, Kevin M Harlen, Kate C Lachance, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman

Publikováno v: eLife, Vol 11 (2022)

Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NE

Externí odkaz: https://doaj.org/article/423671e31f8c4a3383b5bd9ff2afd815

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