Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristine L. P. Garcia"'
Publikováno v:
Addiction Biology. 22:1257-1266
Nicotine can be metabolized by the enzyme CYP2B; brain CYP2B is higher in rats and monkeys treated with nicotine, and in human smokers. A 7-day nicotine treatment increased CYP2B expression in rat brain but not liver, and decreased the behavioral res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72a285a3027f453f544aac4c6e5c3f1b
https://doi.org/10.1111/adb.12411
https://doi.org/10.1111/adb.12411
Autor:
Douglas H. Sweet, Satish Sharan, Swati Nagar, Kristine L. P. Garcia, Dan A. Rock, Rachel F. Tyndale, Robert S. Foti
Publikováno v:
Drug Metabolism and Disposition. 43:1156-1168
The recent symposium on "Target-Site" Drug Metabolism and Transport that was sponsored by the American Society for Pharmacology and Experimental Therapeutics at the 2014 Experimental Biology meeting in San Diego is summarized in this report. Emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f94bc4d0a59ce3f3aa1e1b8a2eac25
https://doi.org/10.1124/dmd.115.064576
https://doi.org/10.1124/dmd.115.064576
The CYP2B enzyme is expressed in human and rat brain, and metabolizes many CNS-acting drugs. The gene that encodes human CYP2B6 is highly polymorphic, where the variation in brain enzyme levels could result in altered brain drug levels. CYP2B can met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc711d52a2b81a44474d5b5db4bf0d
https://europepmc.org/articles/PMC4839514/
https://europepmc.org/articles/PMC4839514/
Few studies investigate factors that influence acquisition in nicotine self-administration (NSA), such as food training and training dose. Most have utilized peak doses along nicotine’s dose-response curve (15 and 30 μg/kg) that establish NSA in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff46fb9637cb68dc9c7fcb45ec838075
https://europepmc.org/articles/PMC4179974/
https://europepmc.org/articles/PMC4179974/
Autor:
Garcia, Kristine L. P.1,2, Lê, Anh Dzung1,2, Tyndale, Rachel F.1,2 r.tyndale@utoronto.ca, Lê, Anh Dzung3,4 (AUTHOR)
Publikováno v:
Addiction Biology. Sep2017, Vol. 22 Issue 5, p1257-1266. 10p.