Stability selection enhances feature selection and enables accurate prediction of gestational age using only five DNA methylation sites

Autor: Kristine L. Haftorn, Julia Romanowska, Yunsung Lee, Christian M. Page, Per M. Magnus, Siri E. Håberg, Jon Bohlin, Astanand Jugessur, William R. P. Denault

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)

Abstract Background DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks that can accurately predict

Externí odkaz: https://doaj.org/article/9440ffacbf8147afa22264161d9bbb13

Nucleated red blood cells explain most of the association between DNA methylation and gestational age

Autor: Kristine L. Haftorn, William R. P. Denault, Yunsung Lee, Christian M. Page, Julia Romanowska, Robert Lyle, Øyvind E. Næss, Dana Kristjansson, Per M. Magnus, Siri E. Håberg, Jon Bohlin, Astanand Jugessur

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)

CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.

Externí odkaz: https://doaj.org/article/685ca7f611554c978bb43c19b97d8d3b

Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array

Autor: Yunsung Lee, Kristine L. Haftorn, William R. P. Denault, Haakon E. Nustad, Christian M. Page, Robert Lyle, Sindre Lee-Ødegård, Gunn-Helen Moen, Rashmi B. Prasad, Leif C. Groop, Line Sletner, Christine Sommer, Maria C. Magnus, Håkon K. Gjessing, Jennifer R. Harris, Per Magnus, Siri E. Håberg, Astanand Jugessur, Jon Bohlin

Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)

Abstract Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina HumanMethylation450 BeadChip (

Externí odkaz: https://doaj.org/article/0615d625d2304aafb5a4fea374fd2938

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Autor: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Jari Lahti, Caroline L. Relton, Gemma C. Sharp, Melanie Waldenberger, Veit Grote, Barbara Heude, Isabella Annesi-Maesano, Marie-France Hivert, Ana C. Zenclussen, Gunda Herberth, Dana Dabelea, Regina Grazuleviciene, Marina Vafeiadi, Siri E. Håberg, Stephanie J. London, Mònica Guxens, Rebecca C. Richmond, Charlotte A. M. Cecil

Publikováno v: Clinical Epigenetics
Sammallahti, S, Koopman-Verhoeff, M E, Binter, A-C, Mulder, R H, Cabré-Riera, A, Kvist, T, Malmberg, A L K, Pesce, G, Plancoulaine, S, Heiss, J A, Rifas-Shiman, S L, Röder, S W, Starling, A P, Wilson, R, Guerlich, K, Haftorn, K L, Page, C M, Luik, A I, Tiemeier, H, Felix, J F, Raikkonen, K, Lahti, J, Relton, C L, Sharp, G C, Waldenberger, M, Grote, V, Heude, B, Annesi-Maesano, I, Hivert, M-F, Zenclussen, A C, Herberth, G, Dabelea, D, Grazuleviciene, R, Vafeiadi, M, Håberg, S E, London, S J, Guxens, M, Richmond, R C & Cecil, C A M 2022, ' Longitudinal associations of DNA methylation and sleep in children : a meta-analysis ', Clinical Epigenetics, vol. 14, no. 1, 83 . https://doi.org/10.1186/s13148-022-01298-4
Clin Epigenetics
Clin. Epigenet. 14:83 (2022)
Clinical Epigenetics, 14(1):83. BioMed Central Ltd.

BackgroundSleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2f445bae86d3a282445e93757df8eb
http://hdl.handle.net/10852/94594