Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kristine L Skele"'
Autor:
Michele Carbone, Craig W. Menges, Lili Zhang, Agnes B. Kane, Jianming Pei, Kristine L. Skele-Stump, Deborah A. Altomare, Joseph R. Testa
Publikováno v:
Proceedings of the National Academy of Sciences. 106:3420-3425
The human CDKN2A locus encodes 2 distinct proteins, p16(INK4A) and p14(ARF) [mouse p19(Arf)], designated INK4A (inhibitor of cyclin dependent kinase 4) and ARF (alternative reading frame) here, that are translated from alternatively spliced mRNAs. Hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afebaf4d0c6ef322347bb516f37930e
https://doi.org/10.1073/pnas.0808816106
https://doi.org/10.1073/pnas.0808816106
Autor:
Neeraja Idamakanti, Paul L. Hallenbeck, Shanthi Ganesh, Charles M. Rudin, Kevin D. Burroughs, Kristine L. Skele, Carl M. Hay, Jingping Yang, D. Neil Watkins, Laura M. Hales, Shawn S.-C. Li, Brian H. Jones, P. Seshidhar Reddy, Ann Jeanette Vasko
Publikováno v:
Journal of the National Cancer Institute
Background Numerous clinical trials have demonstrated that oncolytic viruses can elicit antitumor responses when they are administered directly into localized cancers. However, the treatment of metastatic disease with oncolytic viruses has been chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0538f8dff9bb04e35dd735e4f47d4d4f
https://doi.org/10.1093/jnci/djm198
https://doi.org/10.1093/jnci/djm198
Autor:
Poulikos I. Poulikakos, Deborah A. Altomare, Francis P. Kuhajda, Hui Qin Wang, Joseph R. Testa, Antonio Di Cristofano, Kristine L Skele
Publikováno v:
Oncogene. 24:3574-3582
Activation of AKT and overexpression of fatty acid synthase (FAS) are frequently observed in human ovarian cancer. To explore a possible connection between AKT and FAS, immunohistochemical analyses were conducted on an ovarian cancer tissue microarra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e0e79b92e237f7a4df4130c60ab33d
https://doi.org/10.1038/sj.onc.1208463
https://doi.org/10.1038/sj.onc.1208463
Autor:
Charles A. Vaslet, Agnes B. Kane, Andrea I. McClatchey, Karthik Devarajan, Suresh C. Jhanwar, Joseph R. Testa, Assunta De Rienzo, Deborah A. Altomare, Kristine L Skele
Publikováno v:
Cancer research. 65(18)
Malignant mesothelioma has been linked to asbestos exposure and generally has a poor prognosis because it is often diagnosed in advanced stages and is refractory to conventional therapy. Human malignant mesotheliomas accumulate multiple somatic genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1b868e0aca5432d294a353a7bc32b1
https://pubmed.ncbi.nlm.nih.gov/16166281
https://pubmed.ncbi.nlm.nih.gov/16166281
Autor:
Agnes B. Kane, Guang-Hui Xiao, Joseph R. Testa, Brooke T. Mossman, Assunta De Rienzo, Huihong You, Kristine L Skele, Suresh C. Jhanwar, Maria E. Ramos-Nino, Deborah A. Altomare
Publikováno v:
Oncogene. 24(40)
Malignant mesotheliomas (MMs) are very aggressive tumors that respond poorly to standard chemotherapeutic approaches. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been implicated in tumor aggressiveness, in part by mediating cell survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51561267fca465e8811a0ac2a5287756
https://pubmed.ncbi.nlm.nih.gov/15897870
https://pubmed.ncbi.nlm.nih.gov/15897870
Autor:
Ryan Gallagher, Richard G. Pestell, Deborah A. Altomare, Suresh C. Jhanwar, Justin N Shetler, Kristine L Skele, Joseph R. Testa, Guang-Hui Xiao
Inactivation of the NF2 tumor suppressor gene has been observed in certain benign and malignant tumors. Recent studies have demonstrated that merlin, the product of the NF2 gene, is regulated by Rac/PAK signaling. However, the mechanism by which merl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cdad354d7b25088b4c2ca6a990162a
https://europepmc.org/articles/PMC1061616/
https://europepmc.org/articles/PMC1061616/
Autor:
Kristine L Skele, Deborah A. Altomare, Joseph R. Testa, Hui Qin Wang, Assunta De Rienzo, Andres J. Klein-Szanto, Andrew K. Godwin
Publikováno v:
Oncogene. 23(34)
Activation of the PI3K/AKT pathway may contribute to tumorigenesis. AKT mediates survival signals that protect cells from apoptosis and, thus, is a potentially important therapeutic target. To determine the frequency of AKT activation in human ovaria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa35f1356ef7741c5121394728716ed
https://pubmed.ncbi.nlm.nih.gov/15208673
https://pubmed.ncbi.nlm.nih.gov/15208673
Autor:
John P. Hoffman, Assunta De Rienzo, Kristine L Skele, Sachie Tanno, Deborah A. Altomare, Satoshi Tanno, Joseph R. Testa, Andres J. Klein-Szanto
Publikováno v:
Journal of cellular biochemistry. 87(4)
Activation of AKT/protein kinase B promotes a variety of biological activities important in tumorigenesis, such as cell survival and cell cycle progression. We previously demonstrated amplification and overexpression of the AKT2 gene in a subset of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808da84841f5b8f33a1a12b31280f66c
https://pubmed.ncbi.nlm.nih.gov/14735903
https://pubmed.ncbi.nlm.nih.gov/14735903
Autor:
Joseph R. Testa, Charles A. Vaslet, Norma J. Messier, Agnes B. Kane, Deborah A. Altomare, I. Henderson, Kristine L Skele
Publikováno v:
Lung Cancer. 54:S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff6ee8c5669ce8689b441d1a13567668
https://doi.org/10.1016/s0169-5002(07)70095-8
https://doi.org/10.1016/s0169-5002(07)70095-8