Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors

Autor: Dalton R. Kim, Meghan J. Orr, Ada J. Kwong, Kristine K. Deibler, Hasan H. Munshi, Cory Seth Bridges, Taylor Jie Chen, Xiaoyu Zhang, H. Daniel Lacorazza, Karl A. Scheidt

Publikováno v: ACS Medicinal Chemistry Letters. 14:606-613

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0903b6a3fed7dbb1c35e9c053f680bf
https://doi.org/10.1021/acsmedchemlett.3c00029

Conjugate Additions of Amines to Maleimides via Cooperative Catalysis

Autor: Kristine K. Deibler, Carlos M. Villa, Karl A. Scheidt, Brice E. Uno, Arjun Raghuraman

Publikováno v: Advanced Synthesis & Catalysis. 360:1719-1725

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d72c4d7dc26dde19f1106b8673ac3a3
https://doi.org/10.1002/adsc.201800160

Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist.

Autor: Polex-Wolf J; Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Deibler K; Novo Nordisk Research Center Seattle, Novo Nordisk A/S, 530 Fairview Ave N #5000, Seattle, WA 98109, USA., Hogendorf WFJ; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Bau S; Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Glendorf T; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Stidsen CE; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Tornøe CW; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Tiantang D; Novo Nordisk Research Center China, Novo Nordisk A/S, Shengmingyuan West Ring Rd, Changping District, Beijing, 102206 China., Lundh S; Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Pyke C; Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Tomlinson AJ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Kernodle S; Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA., Magrisso IJ; Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA., Conde-Frieboes KW; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Myers MG Jr; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Knudsen LB; Chief Scientific Advisor Office, Novo Nordisk A/S, Novo Nordisk Park, 2760 Måløv, Denmark., Seeley RJ; Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Dec 04; Vol. 16 (776), pp. eadk4908. Date of Electronic Publication: 2024 Dec 04.

Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.

Autor: Muratspahić E; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Deibler K; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Novo Nordisk Research Center Seattle, Novo Nordisk A/S, 530 Fairview Ave N #5000, Seattle, WA, 97403, USA., Han J; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, 63110, USA., Tomašević N; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090, Vienna, Austria., Jadhav KB; Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090, Vienna, Austria., Olivé-Marti AL; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria., Hochrainer N; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria., Hellinger R; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090, Vienna, Austria., Koehbach J; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD, 4072, Australia.; School of Biomedical Sciences, Faculty for Medicine, The University of Queensland, Brisbane, QLD, 4072, Australia., Fay JF; Department of Biochemistry and Molecular Biology, University of Maryland Baltimore, Baltimore, MD, 21201, USA., Rahman MH; Department of Pharmaceutical and Administrative Sciences, Saint Louis College of Pharmacy, University of Health Sciences & Pharmacy in St. Louis, St. Louis, MO, 63110, USA., Hegazy L; Department of Pharmaceutical and Administrative Sciences, Saint Louis College of Pharmacy, University of Health Sciences & Pharmacy in St. Louis, St. Louis, MO, 63110, USA., Craven TW; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Varga BR; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Bhardwaj G; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Appourchaux K; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Majumdar S; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Muttenthaler M; Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, 1090, Vienna, Austria.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Hosseinzadeh P; Department of Bioengineering, Knight Campus, University of Oregon, Eugene, OR, 97403, USA., Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD, 4072, Australia., Spetea M; Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria., Che T; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, MO, 63110, USA. taoche@wustl.edu.; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. taoche@wustl.edu., Baker D; Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, Washington, WA, 98195, USA. dabaker@uw.edu., Gruber CW; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090, Vienna, Austria. christian.w.gruber@meduniwien.ac.at.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 06; Vol. 14 (1), pp. 8064. Date of Electronic Publication: 2023 Dec 06.

An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor.

Autor: Bhushan B; Department of Chemistry, Oxford University, Chemistry Research Laboratory 12 Mansfield Road Oxford OX1 3TA UK Akane.Kawamura@chem.ox.ac.uk., Granata D; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., Kaas CS; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., Kasimova MA; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., Ren Q; Novo Nordisk Research Center China Novo Nordisk A/S, Shengmingyuan West Ring Rd Changping District Beijing China., Cramer CN; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., White MD; Department of Chemistry, Oxford University, Chemistry Research Laboratory 12 Mansfield Road Oxford OX1 3TA UK Akane.Kawamura@chem.ox.ac.uk., Hansen AMK; Global Drug Discovery Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark., Fledelius C; Global Drug Discovery Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark., Invernizzi G; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., Deibler K; Novo Nordisk Research Center Seattle Novo Nordisk A/S, 530 Fairview Ave N # 5000 Seattle WA 98109 USA., Coleman OD; School of Natural and Environmental Sciences, Chemistry, Newcastle University Bedson Building, Kings Road Newcastle University Newcastle Upon Tyne NE1 7RU UK Akane.Kawamura@ncl.ac.uk., Zhao X; Novo Nordisk Research Center China Novo Nordisk A/S, Shengmingyuan West Ring Rd Changping District Beijing China., Qu X; Novo Nordisk Research Center China Novo Nordisk A/S, Shengmingyuan West Ring Rd Changping District Beijing China., Liu H; Novo Nordisk Research Center China Novo Nordisk A/S, Shengmingyuan West Ring Rd Changping District Beijing China., Zurmühl SS; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., Kodra JT; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com., Kawamura A; Department of Chemistry, Oxford University, Chemistry Research Laboratory 12 Mansfield Road Oxford OX1 3TA UK Akane.Kawamura@chem.ox.ac.uk.; School of Natural and Environmental Sciences, Chemistry, Newcastle University Bedson Building, Kings Road Newcastle University Newcastle Upon Tyne NE1 7RU UK Akane.Kawamura@ncl.ac.uk., Münzel M; Global Research Technologies Novo Nordisk A/S, Novo Nordisk Park 2760 Måløv Denmark myzm@novonordisk.com dngt@novonordisk.com.

Publikováno v: Chemical science [Chem Sci] 2022 Feb 24; Vol. 13 (11), pp. 3256-3262. Date of Electronic Publication: 2022 Feb 24 (Print Publication: 2022).