Výsledky vyhledávání - "Kristine Hogan"

Mapping the Binding Site of Melanocortin 4 Receptor Agonists: A Hydrophobic Pocket Formed by I3.28(125), I3.32(129), and I7.42(291) Is Critical for Receptor Activation

Autor: Sandy Gould, Irache Visiers, Ian Parsons, Dominic Ryan, Kristine Hogan, Stephan Peluso, Lijun Wu

Publikováno v: Journal of Medicinal Chemistry. 49:911-922

The melanocortin 4 receptor is involved in the control of the feeding behavior and energy homeostasis. It is regulated by internal agonist (alpha-MSH) and antagonists (Agouti). Peptide agonists bind in a beta-turn conformation that organizes the char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fbdb9dbbd37099ed5527fcb2c91597
https://doi.org/10.1021/jm050780s

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Improving the long-term storage of a mammalian biosensor cell line via genetic engineering

Autor: Deborah J. Wright, Frances Nargi, Richard F. Helm, Kristine Hogan, Thomas H. MacRae, Marie Bohane, Theresa Towle, Malcolm Potts, Martha S. Petrovick

Publikováno v: Biotechnology and Bioengineering.

The unique properties of mammalian cells make them valuable for a variety of applications in medicine, industry, and diagnostics. However, the utility of such cells is restricted due to the difficulty in storing them non-frozen for an extended time a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c50023f78daf4d8e3633f1c4c43cd00
https://doi.org/10.1002/bit.22700

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CTP-221, a Deuterated S-Enantiomer of Lenalidomide, Possesses Significantly Enhanced Immunomodulatory and Anti-Proliferative Properties Relative to the R-Enantiomer and to Racemic Lenalidomide

Autor: Roger Tung, Ara M. Aslanian, Kristine Hogan, Julie F. Liu, Lijun Wu

Publikováno v: Blood. 120:2463-2463

Abstract 2463 Lenalidomide (Revlimid®) is an immunomodulatory drug (IMiD) currently approved for the treatment of 5q- myelodysplastic syndrome and multiple myeloma. The clinical efficacy of lenalidomide is thought to be related in part to enhanced T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f58e01f38e269404b7b4f1ece1c685f1
https://doi.org/10.1182/blood.v120.21.2463.2463

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