Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristine F Parson"'
Autor:
Daniel D. Vallejo, Chae Kyung Jeon, Kristine F. Parson, Hayley R. Herderschee, Joseph D. Eschweiler, Dana I. Filoti, Brandon T. Ruotolo
Publikováno v:
Analytical Chemistry. 94:6745-6753
Stability is a key critical quality attribute monitored throughout the development of monoclonal antibody (mAb) therapeutics. Minor changes in their higher order structure (HOS) caused by stress or environment may alter mAb aggregation, immunogenicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30baf8cbb571aa86626d2ebb16cd28d
https://doi.org/10.1021/acs.analchem.2c00160
https://doi.org/10.1021/acs.analchem.2c00160
Autor:
Daniel D. Vallejo, Carolina Rojas Ramírez, Kristine F. Parson, Yilin Han, Varun V. Gadkari, Brandon T. Ruotolo
Publikováno v:
Chem Rev
Mass spectrometry is a central technology in the life sciences, providing our most comprehensive account of the molecular inventory of the cell. In parallel with developments in mass spectrometry technologies targeting such assessments of cellular co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0259615a9ca36bb34f37325f265aa6c4
https://pubmed.ncbi.nlm.nih.gov/35316030
https://pubmed.ncbi.nlm.nih.gov/35316030
Autor:
Mu-Ping Nieh, Holger A. Scheidt, Scott E Collier, Daniel Huster, Melissa G. Chambers, Robert L. McFeeters, George A. Pantelopulos, Kristine F Parson, Haley R. Harrington, Brandon T. Ruotolo, Kathleen F. Mittendorf, John E. Straub, Markus Voehler, Richard A. Stein, Charles R. Sanders, John Katsaras, Shuo Qian, Sarah M Fantin, Kuo-Chih Shih, James M. Hutchison
Publikováno v:
J Am Chem Soc
How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids and cholesterol. This g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af23aeea4e0d960366b4c7c1dac8c400
https://doi.org/10.1021/jacs.0c04669
https://doi.org/10.1021/jacs.0c04669
Autor:
Jian Liu, Brandon T. Ruotolo, Sarah M Fantin, Shuai Niu, Sugyan M. Dixit, Shelagh Ferguson-Miller, Kristine F Parson, Daniel A. Polasky
Publikováno v:
Analytical Chemistry. 91:15469-15476
Membrane proteins represent most current therapeutic targets, yet remain understudied due to their insolubility in aqueous solvents and generally low yields during purification and expression. Ion mobility-mass spectrometry and collision induced unfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b92d62bbc0f808ca3823fb163b4c7f
https://doi.org/10.1021/acs.analchem.9b03208
https://doi.org/10.1021/acs.analchem.9b03208
Autor:
Shramana Chatterjee, Kristine F. Parson, Brandon T. Ruotolo, John McCracken, Jian Hu, Robert P. Hausinger
Publikováno v:
Journal of Biological Chemistry. 298:102131
Sulfur-insertion reactions are essential for the biosynthesis of several cellular metabolites, including enzyme cofactors. In Lactobacillus plantarum, a sulfur-containing nickel-pincer nucleotide (NPN) cofactor is used as a coenzyme of lactic acid ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a9fc3cbca2278a13e579b2c1b3a946
https://doi.org/10.1016/j.jbc.2022.102131
https://doi.org/10.1016/j.jbc.2022.102131
Autor:
Brock Juliano, Geoffrey Li, Charles R. Sanders, Melanie D. Ohi, Kristine F Parson, Brandon T. Ruotolo, Pramod Kumar Yadav, Sarah M Fantin
Publikováno v:
Proc Natl Acad Sci U S A
Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma membrane destination in myelinating Schwann cells. Misfolding of PMP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9948e2bbd7f5ae7300539ab5d63e796e
https://doi.org/10.1073/pnas.2015331118
https://doi.org/10.1073/pnas.2015331118
Autor:
Manuel A. Castro, Kristine F. Parson, Ilyas Beg, Mason C. Wilkinson, Kamila Nurmakova, Iliana Levesque, Markus W. Voehler, Michael S. Wolfe, Brandon T. Ruotolo, Charles R. Sanders
Publikováno v:
Journal of Biological Chemistry. 298:101792
This work reports substrate-selective inhibition of a protease with broad substrate specificity based on direct binding of a small-molecule inhibitor to the substrate. The target for these studies was γ-secretase protease, which cleaves dozens of di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8248788c724b6d4de70958db33e2c58d
https://doi.org/10.1016/j.jbc.2022.101792
https://doi.org/10.1016/j.jbc.2022.101792