Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Kristine E. Kamm"'
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193769 (2018)
Aortic smooth muscle contains limiting amounts of myosin light chain kinase (MLCK) for myosin regulatory light chain (RLC) phosphorylation and contraction that predisposes to thoracic aortic disease in humans containing heterozygous loss-of-function
Externí odkaz:
https://doaj.org/article/01b18a802f6143478d091ebe42da7829
Autor:
Audrey N Chang, Jian Huang, Pavan K Battiprolu, Joseph A Hill, Kristine E Kamm, James T Stull
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66720 (2013)
Activation of ErbB2/4 receptor tyrosine kinases in cardiomyocytes by neuregulin treatment is associated with improvement in cardiac function, supporting its use in human patients with heart failure despite the lack of a specific mechanism. Neuregulin
Externí odkaz:
https://doaj.org/article/af4896ad63ba4e76a316cffc80e75090
Autor:
Xue Yan Duan, Zhen Zhou, Kaveeta Kaw, Dianna M. Milewicz, Kristine E. Kamm, Abhijnan Chattopadhyay, James T. Stull, Jian Huang, Shuangtao Ma, Kathleen M. Trybus, Patricia M. Fagnant, Callie S. Kwartler, Zhenan Liu, Jiyuan Chen, Hailong Lu
Publikováno v:
Journal of Biological Chemistry. 297:101228
Pathogenic variants of the gene for smooth muscle α-actin (ACTA2), which encodes smooth muscle (SM) α-actin, predispose to heritable thoracic aortic disease. The ACTA2 variant p.Arg149Cys (R149C) is the most common alteration; however, only 60% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8781ca3caa3f8bdcf132ae9105d4c2e
https://doi.org/10.1016/j.jbc.2021.101228
https://doi.org/10.1016/j.jbc.2021.101228
Autor:
Wei-Qi He, Ning Gao, Cai Ping Chen, James T. Stull, Audrey N. Chang, Kristine E. Kamm, Ming Ho Tsai, Min-Sheng Zhu
Publikováno v:
The Journal of Physiology. 595:6231-6247
Key points Smooth muscle myosin regulatory light chain (RLC) is phosphorylated by Ca2+/calmodulin-dependent myosin light chain kinase and dephosphorylated by myosin light chain phosphatase (MLCP). Tracheal smooth muscle contains significant amounts o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ae0a3eb8dcf51287d939ba006ebd2a5
https://doi.org/10.1113/jp274715
https://doi.org/10.1113/jp274715
Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections
Autor:
Dongchuan Guo, Kristine E. Kamm, Lee L. Sweeney, James T. Stull, Dianna M. Milewicz, Ellen S. Regalado, Kathleen M. Trybus
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37:26-34
The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major structural proteins or kinases controlling contraction lead to the formation of aneurysms of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1f144b64b0ac5db4300b6cd6a6bc71
https://doi.org/10.1161/atvbaha.116.303229
https://doi.org/10.1161/atvbaha.116.303229
Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription
Autor:
Ashutosh Kumar, Maria D. Person, Jing Xiao, Zhenan Liu, Yuan Zhong, Dianna M. Milewicz, Amelie Albrecht, Kathleen M. Trybus, Xuetong Shen, Adrian Maples, Kristine E. Kamm, Bin Liu, Vinesh Vinayachandran, Chia Fang Lee, B. Franklin Pugh, Kam Y. J. Zhang, Jiyuan Chen, Ashok Kumar, Bongsoo Park, Jianjun Shen, Rohit Reja, Pau Biak Sang, Prabodh Kapoor
Publikováno v:
Cell reports. 32(13)
Summary Nuclear actin has been elusive due to the lack of knowledge about molecular mechanisms. From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on an evolutionarily conserved R256 residue of actin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab076ad95a850f53cf966df3908ead78
https://pubmed.ncbi.nlm.nih.gov/32997990
https://pubmed.ncbi.nlm.nih.gov/32997990
Autor:
Wei-Qi He, Audrey N. Chang, Yan Ning Qiao, James T. Stull, Cai Ping Chen, Ning Gao, Kristine E. Kamm, Min-Sheng Zhu
Publikováno v:
The Journal of Physiology. 594:3209-3225
Key points The extent of myosin regulatory light chain phosphorylation (RLC) necessary for smooth muscle contraction depends on the respective activities of Ca(2+) /calmodulin-dependent myosin light chain kinase and myosin light chain phosphatase (ML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f8048e895227403055cbea194b6463
https://doi.org/10.1113/jp271703
https://doi.org/10.1113/jp271703
Autor:
Alexandra Janda, Jian Huang, Richard J. Kulmacz, James T. Stull, Xue Yan Duan, Dongchuan Guo, Kristine E. Kamm, Limin Gong, Jiyuan Chen, Dianna M. Milewicz, Shanzhi Wang, Callie S. Kwartler
Thoracic aortic aneurysms leading to acute aortic dissections are a preventable cause of premature deaths if individuals at risk can be identified. Individuals with early-onset aortic dissections without a family history or syndromic features have an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612a8c0ca3edea34b38a9a69b8581259
https://europepmc.org/articles/PMC6035370/
https://europepmc.org/articles/PMC6035370/
Autor:
James T. Stull, Jian Huang, Audrey N. Chang, Ning Gao, Zhenan Liu, Kristine E. Kamm, Angus C. Nairn
Publikováno v:
The Journal of biological chemistry. 293(43)
Contractile force development of smooth muscle is controlled by balanced kinase and phosphatase activities toward the myosin regulatory light chain (RLC). Numerous biochemical and pharmacological studies have investigated the specificity and regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b127b28ada777714a098a63779435b
https://pubmed.ncbi.nlm.nih.gov/30185619
https://pubmed.ncbi.nlm.nih.gov/30185619
Autor:
Xin Chen, James T. Stull, Chen Chen, Yan Ning Qiao, Cai Ping Chen, Min-Sheng Zhu, Kristine E. Kamm, Pei Wang, Jie Sun, Tao Tao, Ning Gao, Ye Wang, Wei Zhao, Yun Qian Gao, Cheng-Hai Zhang, Wei-Qi He
Publikováno v:
The Journal of Physiology. 593:681-700
Key points Force production and maintenance in smooth muscle is largely controlled by myosin regulatory light chain (RLC) phosphorylation, which relies on a balance between Ca2+/calmodulin-dependent myosin light chain kinase (MLCK) and myosin light c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d81e718c27dba28e65a8b1958c6b835
https://doi.org/10.1113/jphysiol.2014.283853
https://doi.org/10.1113/jphysiol.2014.283853