Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kristine B. Berst"'
Autor:
Bryce V. Plapp, Kristine B. Berst
Publikováno v:
Chemico-Biological Interactions. :183-193
The steady-state kinetics of the recombinant human alcohol dehydrogenase (ADH) 1C*2 with steroids were studied in order to determine substrate and inhibitor specificity. The assays were carried out under conditions of pH and temperature that are simi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf846084ffd0e190b20de0e941d9769e
https://doi.org/10.1016/s0009-2797(02)00202-8
https://doi.org/10.1016/s0009-2797(02)00202-8
Publikováno v:
Biochemistry. 37:14267-14278
The binding of N-cyclohexylformamide (CXF) to the complex of horse liver alcohol dehydrogenase with NADH mimics that of the Michaelis complex for aldehyde reduction catalyzed by the enzyme. The Raman spectra of bound CXF and its 13C- and 15N-substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7a7a3586fdba24ac144fb7466d3479
https://doi.org/10.1021/bi981477e
https://doi.org/10.1021/bi981477e
Publikováno v:
Journal of Medicinal Chemistry. 41:1696-1701
Human alcohol dehydrogenase (HsADH) comprises class I (alpha, beta, and gamma), class II (pi), and class IV (sigma) enzymes. Selective inhibitors of the enzymes could be used to prevent the metabolism of alcohols that form toxic products. Formamides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f5596c4a7278798efa0e6065d57b45
https://doi.org/10.1021/jm9707380
https://doi.org/10.1021/jm9707380
Autor:
Gregg Duester, Neal L. Weintraub, Bryce V. Plapp, Arthur A. Spector, Xiang Fang, T. Verugopal Raju, John R. Falck, Kristine B. Berst, Steven A. Moore, Xixuan H. Collins, Shawn D. Harmon, Terry L. Kaduce
Publikováno v:
The Journal of biological chemistry. 280(39)
20-Carboxyeicosatetraenoic acid (20-COOH-AA) is a bioactive metabolite of 20-hydroxyeicosatetraenoic acid (20-HETE), an eicosanoid that produces vasoconstriction in the cerebral circulation. We found that smooth muscle (MSMC) and endothelial (MEC) cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03841cd39c12f26d47b3a61a613ab8de
https://pubmed.ncbi.nlm.nih.gov/16081420
https://pubmed.ncbi.nlm.nih.gov/16081420
Publikováno v:
Biochemistry. 43(5)
ADH2 is a member of one of the six classes of mammalian alcohol dehydrogenases, which catalyze the reversible oxidation of alcohols using NAD(+) as a cofactor. Within the ADH2 class, the rodent enzymes form a subgroup that exhibits low catalytic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c45e6973366ed584ba79959f3e642a
https://pubmed.ncbi.nlm.nih.gov/14756569
https://pubmed.ncbi.nlm.nih.gov/14756569
Publikováno v:
Chemico-biological interactions. (1-3)
Mouse ADH4 (purified, recombinant) has a low catalytic efficiency for ethanol and acetaldehyde, but very high activity with longer chain alcohols and aldehydes, at pH 7.3 and temperature 37 degrees C. The observed turnover numbers and catalytic effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41094d8985953f028176888f67f87e1
https://pubmed.ncbi.nlm.nih.gov/11306066
https://pubmed.ncbi.nlm.nih.gov/11306066
Autor:
Deanne Crowell, Michael D. Tufano, Kennan C. Marsh, Kristine B. Berst, Jacob J. Plattner, Lisa A. Hasvold, Daniel T. W. Chu, Qun Li, Angela M. Nilius, Linus L. Shen, Weibo Wang, Kathleen Raye, Akiyo K. Claiborne, Jeff Alder, Robert K. Flamm
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(15)
The 8-position side chain of 2-pyridones is believed to be involved in the binding with bacterial DNA gyrase to form the ternary complex, making them very important for the activity of 2-pyridones. A series of 2-pyridones having fluoro-substituted am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93775667e7384571f427311a12afcffb
https://pubmed.ncbi.nlm.nih.gov/9873465
https://pubmed.ncbi.nlm.nih.gov/9873465
Autor:
Kristine B. Berst, Heeyeong Cho, Michael Scholze, John F. Schindler, S. Ramaswamy, Kevin G. Leidal, Bryce V. Plapp, Vijay K. Chadha
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461371465
Selective inhibitors of alcohol dehydrogenases could be useful for prevention of poisoning due to metabolism of alcohols, such as methanol or ethylene glycol, that lead to toxic products (Jacobsen and McMartin, 1997). Good inhibitors could also be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d2b63b064d540583341e56ff8edf12
https://doi.org/10.1007/978-1-4615-4735-8_36
https://doi.org/10.1007/978-1-4615-4735-8_36
Autor:
Qun Li, Daniel T. W. Chu, Akiyo Claiborne, Curt S. Cooper, Cheuk M. Lee, Kathleen Raye, Kristine B. Berst, Pamela Donner, Weibo Wang, Lisa Hasvold, Anthony Fung, Zhenkun Ma, Michael Tufano, Robert Flamm, Linus L. Shen, John Baranowski, Angela Nilius, Jeff Alder, Jonathan Meulbroek, Kennan Marsh, DeAnne Crowell, Yuhua Hui, Louis Seif, Laura M. Melcher, Rodger Henry, Steven Spanton, Ramin Faghih, Larry L. Klein, S. Ken Tanaka, Jacob J. Plattner
Publikováno v:
Journal of medicinal chemistry. 39(16)
Two novel series of 2-pyridones were synthesized by transposition of the nitrogen of 4-quinolones to the bridgehead position. This subtle interchange of the nitrogen atom with a carbon atom yielded two novel heterocyclic nuclei, pyrido[1,2-alpha]pyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a50a29d2238b79a28999613a1a9301d
https://pubmed.ncbi.nlm.nih.gov/8759628
https://pubmed.ncbi.nlm.nih.gov/8759628