Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristine A. Abo"'
Publikováno v:
Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-5 (2023)
Abstract Background Pituitary apoplexy is acute infarction with or without hemorrhage of the pituitary gland. It is a rare but potentially life-threatening emergency that most commonly occurs in the setting of pituitary adenoma. The mechanisms underl
Externí odkaz:
https://doaj.org/article/0f3b68741c284caca9a6fb932da8a876
Autor:
Kristine M. Abo, Julio Sainz de Aja, Jonathan Lindstrom-Vautrin, Konstantinos-Dionysios Alysandratos, Alexsia Richards, Carolina Garcia-de-Alba, Jessie Huang, Olivia T. Hix, Rhiannon B. Werder, Esther Bullitt, Anne Hinds, Isaac Falconer, Carlos Villacorta-Martin, Rudolf Jaenisch, Carla F. Kim, Darrell N. Kotton, Andrew A. Wilson
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Type 2 alveolar epithelial cells (AT2s), facultative progenitor cells of the lung alveolus, play a vital role in the biology of the distal lung. In vitro model systems that incorporate human cells, recapitulate the biology of primary AT2s, and interf
Externí odkaz:
https://doaj.org/article/42389eda8ce941c3bc455d6c05c41b76
Autor:
Ruobing Wang, Adam J. Hume, Mary Lou Beermann, Chantelle Simone-Roach, Jonathan Lindstrom-Vautrin, Jake Le Suer, Jessie Huang, Judith Olejnik, Carlos Villacorta-Martin, Esther Bullitt, Anne Hinds, Mahboobe Ghaedi, Stuart Rollins, Rhiannon B. Werder, Kristine M. Abo, Andrew A. Wilson, Elke Mühlberger, Darrell N. Kotton, Finn J. Hawkins
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L462-L478
There is an urgent need to understand how SARS-CoV-2 infects the airway epithelium and in a subset of individuals leads to severe illness or death. Induced pluripotent stem cells (iPSCs) provide a near limitless supply of human cells that can be diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c11daf317db3d8d2e025dfc4b0110bb
https://doi.org/10.1152/ajplung.00397.2021
https://doi.org/10.1152/ajplung.00397.2021
Autor:
Rhiannon B. Werder, Tao Liu, Kristine M. Abo, Jonathan Lindstrom-Vautrin, Carlos Villacorta-Martin, Jessie Huang, Anne Hinds, Nathan Boyer, Esther Bullitt, Marc Liesa, Edwin K. Silverman, Darrell N. Kotton, Michael H. Cho, Xiaobo Zhou, Andrew A. Wilson
Publikováno v:
Science advances. 8(28)
Genome-wide association studies (GWAS) have identified dozens of loci associated with chronic obstructive pulmonary disease (COPD) susceptibility; however, the function of associated genes in the cell type(s) affected in disease remains poorly unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6080724d29fb0756ce5fbcad6ad99e0f
https://pubmed.ncbi.nlm.nih.gov/35857525
https://pubmed.ncbi.nlm.nih.gov/35857525
Autor:
Andrew A. Wilson, Darrell N. Kotton, Claire L. Burgess, Andrea B. Alber, Kayleigh Berthiaume, Carly Merritt, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Olivia T. Hix, Kristine M. Abo, Jessie Huang, Rhiannon B. Werder
Publikováno v:
Journal of Visualized Experiments.
In the lung, the alveolar epithelium is a physical barrier from environmental stimuli and plays an essential role in homeostasis and disease. Type 2 alveolar epithelial cells (AT2s) are the facultative progenitors of the distal lung epithelium. Dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5d07c5a840b5ce17867d47725fecaa
https://doi.org/10.3791/63875-v
https://doi.org/10.3791/63875-v
Autor:
Lisa Miorin, Chad E. Mire, Shahin Ranjbar, Adam J. Hume, Jessie Huang, Nicholas A. Crossland, Kris M White, Manon Laporte, Thomas Kehrer, Viraga Haridas, Elena Moreno, Aya Nambu, Sonia Jangra, Anastasija Cupic, Marion Dejosez, Kristine A. Abo, Anna E. Tseng, Rhiannon B. Werder, Raveen Rathnasinghe, Tinaye Mutetwa, Irene Ramos, Julio Sainz de Aja, Carolina Garcia de Alba Rivas, Michael Schotsaert, Ronald B. Corley, James V. Falvo, Ana Fernandez-Sesma, Carla Kim, Jean-François Rossignol, Andrew A. Wilson, Thomas Zwaka, Darrell N. Kotton, Elke Mühlberger, Adolfo García-Sastre, Anne E. Goldfeld
Publikováno v:
bioRxiv
A well-tolerated and cost-effective oral drug that blocks SARS-CoV-2 growth and dissemination would be a major advance in the global effort to reduce COVID-19 morbidity and mortality. Here, we show that the oral FDA-approved drug nitazoxanide (NTZ) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945ea80f17c5b78795ee125d768d7ff6
https://doi.org/10.1101/2022.02.08.479634
https://doi.org/10.1101/2022.02.08.479634
Autor:
Ruobing Wang, Adam J. Hume, Mary Lou Beermann, Chantelle Simone-Roach, Jonathan Lindstrom-Vautrin, Jake Le Suer, Jessie Huang, Judith Olejnik, Carlos Villacorta-Martin, Esther Bullitt, Anne Hinds, Mahboobe Ghaedi, Rhiannon B. Werder, Kristine M. Abo, Andrew A. Wilson, Elke Mühlberger, Darrell N. Kotton, Finn J. Hawkins
SummaryThere is an urgent need to understand how SARS-CoV-2 infects the airway epithelium and in a subset of individuals leads to severe illness or death. Induced pluripotent stem cells (iPSCs) provide a near limitless supply of human cells that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df210abe7a5186d47234c0cfba6df03a
https://doi.org/10.1101/2021.07.06.451340
https://doi.org/10.1101/2021.07.06.451340
Autor:
Carlos Villacorta-Martin, Shaghayegh Farhangmehr, Ryan M. Hekman, Mohsan Saeed, Carlos Perea-Resa, Robert A. Davey, Andrew Emili, Jian Zhao, Peter E.A. Ash, Raghuveera Kumar Goel, Benjamin C. Blum, Andrew A. Wilson, Benjamin J. Blencowe, Ulrich Braunschweig, Benjamin Wolozin, Andrew Tilston-Lunel, Darrell N. Kotton, Ji-Xin Cheng, Avik Basu, Alexandra Mora-Martin, Esther Bullitt, Rhiannon B. Werder, Mark E. McComb, Dmitry A. Kretov, Dzmitry Padhorny, Sandeep Ojha, Shawn M. Lyons, Konstantinos D. Alysandratos, Jessie Huang, Anne Hinds, Valentina Perissi, J. J. Patten, Ahmed Youssef, Xaralabos Varelas, John H Connor, Dima Kozakov, Mamta Verma, Dante Bolzan, Indranil Paul, Ellen L Suder, Eric J. Burks, Matthew D. Layne, Elke Mühlberger, Stefan Wuchty, Adam J. Hume, Daniel Cifuentes, Sadhna Phanse, Julian H. Kwan, Michael D. Blower, Kristine M. Abo
Publikováno v:
Molecular Cell
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469deb34c0395f965c7f17d2e99c8022
Autor:
Konstantinos-Dionysios Alysandratos, Eric J. Burks, Mary Lou Beermann, Ellen L Suder, Ruobing Wang, Esther Bullitt, Jessie Huang, Kristine M. Abo, Judith Olejnik, Chantelle Simone-Roach, Arjun Sharma, Elke Mühlberger, Adam J. Hume, Mohsan Saeed, Rhiannon B. Werder, Markus Bosmann, Jonathan Lindstrom-Vautrin, Darrell N. Kotton, Anne Hinds, Carlos Villacorta-Martin, Andrew A. Wilson, Finn Hawkins
Publikováno v:
Cell Stem Cell
bioRxiv
bioRxiv
A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to access these cells from patients, particularly at early stages of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c432234a47b379d371f5e87c7d420ca7
http://europepmc.org/articles/PMC7500949
http://europepmc.org/articles/PMC7500949
Autor:
Rhiannon B. Werder, Andrew A. Wilson, Taylor Matte, Konstantinos D. Alysandratos, Finn Hawkins, Jonathan Lindstrom-Vautrin, Aditya Mithal, Kristine M. Abo, Carlos Villacorta-Martin, Darrell N. Kotton, Jessie Huang, Gustavo Mostoslavsky, Liang Ma, Laertis Ikonomou, Mary Lou Beermann
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Development of an anti-SARS-CoV-2 therapeutic is hindered by the lack of physiologically relevant model systems that can recapitulate host-viral interactions in human cell types, specifically the epithelium of the lung. Here, we compare induced pluri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf6c088d976a317995b36b081a50bdb
http://europepmc.org/articles/PMC7302183
http://europepmc.org/articles/PMC7302183