Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Kristine Broglio"'
Autor:
William J. Meurer, Florian F. Schmitzberger, Sharon Yeatts, Viswanathan Ramakrishnan, Benjamin Abella, Tom Aufderheide, William Barsan, Justin Benoit, Scott Berry, Joy Black, Nia Bozeman, Kristine Broglio, Jeremy Brown, Kimberly Brown, Noelle Carlozzi, Angela Caveney, Sung-Min Cho, Hangyul Chung-Esaki, Robert Clevenger, Robin Conwit, Richelle Cooper, Valentina Crudo, Mohamud Daya, Deneil Harney, Cindy Hsu, Nicholas J. Johnson, Imad Khan, Shaveta Khosla, Peyton Kline, Anna Kratz, Peter Kudenchuk, Roger J. Lewis, Chaitra Madiyal, Sara Meyer, Jarrod Mosier, Marwan Mouammar, Matthew Neth, Brian O’Neil, James Paxton, Sofia Perez, Sarah Perman, Cemal Sozener, Mickie Speers, Aimee Spiteri, Valerie Stevenson, Kavita Sunthankar, Joseph Tonna, Scott Youngquist, Romergryko Geocadin, Robert Silbergleit, ICECAP trial investigators
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Cardiac arrest is a common and devastating emergency of both the heart and brain. More than 380,000 patients suffer out-of-hospital cardiac arrest annually in the USA. Induced cooling of comatose patients markedly improved neurolo
Externí odkaz:
https://doaj.org/article/d175c8409ccf45f19bb469ca803b04d6
Autor:
Alexander Zarbock, Pierre-François Laterre, Peter Pickkers, Rinaldo Bellomo, Paul Young, Derek C Angus, Kent Doi, Michael Joannidis, Marlies Ostermann, Morten Bestle, Ravindra L Mehta, Patrick T Murray, John A Kellum, Jacques Arend, Christopher J Doig, Ville Pettilä, Bruno Francois, Erik van den Berg, Juliane Bernholz, Kristine Broglio, Jan Carlsen, Ricard Ferrer, Kathleen Liu, Sharon Richards, Anne Louise Kjølbye
Publikováno v:
BMJ Open, Vol 13, Iss 4 (2023)
Introduction Sepsis, the leading cause of acute kidney injury (AKI), is associated with a high morbidity and mortality. Alkaline phosphatase (ALP) is an endogenous detoxifying enzyme. A recombinant human ALP compound, ilofotase alfa, showed no safety
Externí odkaz:
https://doaj.org/article/409c425fa54047969891edcb40c58ebb
Autor:
Charles Conway, Bryan Olin, Scott Aaronson, Harold Sackeim, Mark Bunker, Christopher Kriedt, Teresa Greco, Kristine Broglio, Matteo Vestrucci, John Rush
Publikováno v:
Brain Stimulation, Vol 14, Iss 6, Pp 1666- (2021)
Externí odkaz:
https://doaj.org/article/423c8e3e8dba450ebda5b9c2777ff148
Autor:
Darren Malinoski, Christina Saunders, Sharon Swain, Tahnee Groat, Patrick R. Wood, Jeffrey Reese, Rachel Nelson, Jennifer Prinz, Kate Kishish, Craig Van De Walker, P.J. Geraghty, Kristine Broglio, Claus U. Niemann
Publikováno v:
New England Journal of Medicine. 388:418-426
Autor:
Kristine Broglio, Lale Kostakoglu, Carol Ward, Federico Mattiello, Denis Sahin, Tina Nielsen, Anna McGlothlin, Corrine F. Elliott, Thomas Witzig, Laurie H. Sehn, Marek Trnĕný, Umberto Vitolo, Maurizio Martelli, Margaret Foster, Barbara Wendelberger, Grzegorz Nowakowski, Donald A. Berry
Publikováno v:
Leukemia & Lymphoma. 63:2816-2831
This study's focus is the association of end-of-therapy (EOT) PET results with progression-free (PFS) and overall survival (OS) in patients with diffuse large B-cell lymphoma receiving first-line chemoimmunotherapy. We develop a Bayesian hierarchical
Autor:
Peter Pickkers, Derek C Angus, Jacques Arend, Rinaldo Bellomo, Erik van den Berg, Juliane Bernholz, Morten Bestle, Kristine Broglio, Jan Carlsen, Christopher J Doig, Ricard Ferrer, Michael Joannidis, Bruno Francois, Kent Doi, John A Kellum, Pierre-François Laterre, Kathleen Liu, Ravindra L Mehta, Patrick T Murray, Marlies Ostermann, Ville Pettilä, Sharon Richards, Paul Young, Alexander Zarbock, Anne Louise Kjølbye
Publikováno v:
Pickkers, P, Angus, D C, Arend, J, Bellomo, R, Van Den Berg, E, Bernholz, J, Bestle, M, Broglio, K, Carlsen, J, Doig, C J, Ferrer, R, Joannidis, M, Francois, B, Doi, K, Kellum, J A, Laterre, P F, Liu, K, Mehta, R L, Murray, P T, Ostermann, M, Pettilä, V, Richards, S, Young, P, Zarbock, A & Kjølbye, A L 2023, ' Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury ', BMJ Open, vol. 13, no. 4, e065613 . https://doi.org/10.1136/bmjopen-2022-065613
BMJ Open, 13
BMJ Open, 13, 4
BMJ Open, 13
BMJ Open, 13, 4
IntroductionSepsis, the leading cause of acute kidney injury (AKI), is associated with a high morbidity and mortality. Alkaline phosphatase (ALP) is an endogenous detoxifying enzyme. A recombinant human ALP compound, ilofotase alfa, showed no safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcc74f438a98953a27b573f59256a08
https://curis.ku.dk/ws/files/344643363/e065613.full.pdf
https://curis.ku.dk/ws/files/344643363/e065613.full.pdf
Autor:
Jingjing Ye, Hong Tian, Qi Jiang, Kristine Broglio, Chengxing Cindy Lu, Xiaoming Li, Xiaoyun Nicole Li, Paul Bycott, Anna McGlothlin
Publikováno v:
Therapeutic Innovation & Regulatory Science
Master protocol, categorized as basket trial, umbrella trial or platform trial, is an innovative clinical trial framework that aims to expedite clinical drug development, enhance trial efficiency, and eventually bring medicines to patients faster. De
Autor:
Kristine Broglio, Stephen L. Lake, Melanie Quintana, Jennifer Panagoulias, Michael Panzara, Scott M. Berry
Publikováno v:
Statistics in Medicine. 40:4167-4184
A Bayesian adaptive design is proposed for a clinical trial in Duchenne muscular dystrophy. The trial was designed to demonstrate treatment efficacy on an ambulatory-based clinical endpoint and to identify early success on a biomarker (dystrophin pro
Autor:
Jean Daniel Chiche, Alistair Nichol, Allen C. Cheng, Zahra Bhimani, Peter Kruger, Genevieve K. O'Neill, Paul J Young, Anthony C. Gordon, Jane Parker, Rachael Parke, Derek C. Angus, Kathryn M Rowan, Sebastiaan J. Hullegie, Anne Turner, Anna McGlothlin, Paul R Mouncey, Roger J. Lewis, John Marshall, Farah Al-Beidh, Steven A R Webb, Kristine Broglio, Srinivas Murthy, Lennie P. G. Derde, Colin McArthur, Alisa Higgins, Edward Litton, Scott M. Berry, Yaseen M. Arabi, Gernot Rohde, Menno de Jong, Herman Goossens, Frank M. Brunkhorst, Marc J.M. Bonten, Cameron Green, Wilma van Bentum-Puijk, Shay McGuinness, Michelle A. Detry, Francois Lamontagne
Publikováno v:
Annals of the American Thoracic Society
Annals of the American Thoracic Society, vol 17, iss 7
Proceedings of the American Thoracic Society
Annals of the American Thoracic Society, 17(7), 879-891. American Thoracic Society
Annals of the American Thoracic Society, vol 17, iss 7
Proceedings of the American Thoracic Society
Annals of the American Thoracic Society, 17(7), 879-891. American Thoracic Society
There is broad interest in improved methods to generate robust evidence regarding best practice, especially in settings where patient conditions are heterogenous and require multiple concomitant therapies. Here, we present the rationale and design of
Publikováno v:
Contemporary Clinical Trials. 123:107000
Others have quantified the efficiency of the platform approach as compared to a sequence of independent two-arm trials and have shown the platform approach more efficiently evaluates a set of candidate therapies. However, a practical barrier to initi