Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing.

Autor: Olivier J Becherel, Abrey J Yeo, Alissa Stellati, Evelyn Y H Heng, John Luff, Amila M Suraweera, Rick Woods, Jean Fleming, Dianne Carrie, Kristine McKinney, Xiaoling Xu, Chuxia Deng, Martin F Lavin

Publikováno v: PLoS Genetics, Vol 9, Iss 4, p e1003435 (2013)

Senataxin, mutated in the human genetic disorder ataxia with oculomotor apraxia type 2 (AOA2), plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA damage response. We demonstrate that

Externí odkaz: https://doaj.org/article/2ecf92590ec44c4b86789df144fc8688

mRNA-encoded, constitutively active STING

Autor: Sze-Wah, Tse, Kristine, McKinney, William, Walker, Mychael, Nguyen, Jared, Iacovelli, Clayton, Small, Kristen, Hopson, Tal, Zaks, Eric, Huang

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 29(7)

mRNA vaccines induce potent immune responses in preclinical models and clinical studies. Adjuvants are used to stimulate specific components of the immune system to increase immunogenicity of vaccines. We utilized a constitutively active mutation (V1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e23022f09bfa23ca0de862cdeb5f9f3
https://pubmed.ncbi.nlm.nih.gov/33677092

Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block

Autor: Carol Prives, Kristine McKinney, Masha V. Poyurovsky, Vanesa Gottifredi

Publikováno v: Journal of Biological Chemistry. 279:5802-5810

The cyclin-dependent kinase inhibitor p21, a major transcriptional target of the tumor suppressor p53, plays a critical role in cell cycle arrest in G1 and G2 after DNA damage. It was previously shown that in some human cell lines when S phase is arr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8130ef06411771e4650d14e6afd439
https://doi.org/10.1074/jbc.m310373200

Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carbonyl terminus

Autor: Kristine McKinney, Alan R. Fersht, Michael P. Sheetz, Rachel Beckerman, Andrew Zupnick, Orit Karni-Schmidt, Philippe Bouvet, Assaf Friedler, Melissa Mattia, Carol Prives

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2007, 26, pp.3878-3891. ⟨10.1038/sj.onc.1210162⟩
Oncogene, 2007, 26, pp.3878-3891. ⟨10.1038/sj.onc.1210162⟩

The p53 tumor suppressor is a nucleocytoplasmic shuttling protein that is found predominantly in the nucleus of cells. In addition to mutation, abnormal p53 cellular localization is one of the mechanisms that inactivate p53 function. To further under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7a4fabe5f83eabc959752d9b6fd7cf
https://hal.archives-ouvertes.fr/hal-00378604

Regulation of p53 activity through lysine methylation

Autor: Kristine McKinney, Neil Justin, Steven J. Gamblin, Paul Tempst, Julia K. Kurash, Gleb S. Ivanov, Sergei Chuikov, Danny Reinberg, Carol Prives, Nickolai A. Barlev, Bing Xiao, Jonathan R. Wilson

Publikováno v: Nature. 432(7015)

p53 is a tumour suppressor that regulates the cellular response to genotoxic stresses. p53 is a short-lived protein and its activity is regulated mostly by stabilization via different post-translational modifications. Here we report a novel mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854432ce2b76894384e2d010b2c61153
https://pubmed.ncbi.nlm.nih.gov/15525938