Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kristina von Heyking"'
Autor:
Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Gürgen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach, Günther H. S. Richter
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Abstract Background Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated. Methods Their role was determined using different inhibitors inc
Externí odkaz:
https://doaj.org/article/37a514c7436446fcbab46189c911acc5
Autor:
Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Gürgen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach, Günther H. S. Richter
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-3 (2022)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/e2b35416a024402dba01b1542821c08e
Autor:
Busheng Xue, Kristina von Heyking, Hendrik Gassmann, Mansour Poorebrahim, Melanie Thiede, Kilian Schober, Josef Mautner, Julia Hauer, Jürgen Ruland, Dirk H. Busch, Uwe Thiel, Stefan E. G. Burdach
Publikováno v:
Cancers, Vol 14, Iss 22, p 5485 (2022)
Ewing sarcoma (EwS) is a highly malignant sarcoma of bone and soft tissue with early metastatic spread and an age peak in early puberty. The prognosis in advanced stages is still dismal, and the long-term effects of established therapies are severe.
Externí odkaz:
https://doaj.org/article/cc99fc158bbc4ba997b918c8031ae475
Autor:
Emilie Biele, Sebastian J. Schober, Carolin Prexler, Melanie Thiede, Kristina von Heyking, Hendrik Gassmann, Jennifer Eck, Busheng Xue, Stefan Burdach, Uwe Thiel
Publikováno v:
Cells, Vol 10, Iss 11, p 3070 (2021)
Ewing’s sarcoma (EwS) is a pediatric solid tumor entity with low somatic mutational burden and a low rate of tumor-infiltrating T cells, indicating a low extent of immunogenicity. In EwS, immunogenicity may furthermore be significantly diminished b
Externí odkaz:
https://doaj.org/article/a017ee78320743c3be409bf39ee9343b
Autor:
Hendrik Gassmann, Kira Schneider, Valentina Evdokimova, Peter Ruzanov, Sebastian J. Schober, Busheng Xue, Kristina von Heyking, Melanie Thiede, Guenther H. S. Richter, Michael W. Pfaffl, Elfriede Noessner, Lincoln D. Stein, Poul H. Sorensen, Stefan E. G. Burdach, Uwe Thiel
Publikováno v:
Cells, Vol 10, Iss 8, p 2081 (2021)
Ewing sarcoma (EwS) is an aggressive pediatric cancer of bone and soft tissues characterized by scant T cell infiltration and predominance of immunosuppressive myeloid cells. Given the important roles of extracellular vesicles (EVs) in cancer-host cr
Externí odkaz:
https://doaj.org/article/c1356498953842378fc022432faf6255
Autor:
Günther H.S. Richter, Tim Hensel, Oxana Schmidt, Vadim Saratov, Kristina von Heyking, Fiona Becker-Dettling, Carolin Prexler, Hsi-Yu Yen, Katja Steiger, Simone Fulda, Uta Dirksen, Wilko Weichert, Shudong Wang, Stefan Burdach, Beat W. Schäfer
Publikováno v:
Cancers, Vol 12, Iss 2, p 304 (2020)
Background: Previously, we used inhibitors blocking BET bromodomain binding proteins (BRDs) in Ewing sarcoma (EwS) and observed that long term treatment resulted in the development of resistance. Here, we analyze the possible interaction of BRD4 with
Externí odkaz:
https://doaj.org/article/b51f4be18ecd4743942d53befbb2ef99
Autor:
Carsten Müller-Tidow, Wolfgang E. Berdel, Stefan Burdach, Heribert Jürgens, Daniel Baumhoer, Claudia Rossig, Eva Wardelmann, Wolfgang Hartmann, Gabriele Köhler, Monika Stoll, Anika Witten, Regina Besoke, Isabell Schulze, Matthias Weckesser, Thorsten Buch, Eberhard Korsching, Kathrin Poos, Martin Dugas, Udo Kontny, Hans-Ulrich Klein, Benjamin Moser, Kristina von Heyking, Uta Dirksen, Eva Schmidt, Günther H.S. Richter, Konstantin Agelopoulos
Supplementary Figures S1-6. Supplementary Fig S1: Combined patient characteristics and subjected methods Supplementary Fig. S2 A: ROC curves were constructed by using the somatic scores from the sequenced genotypes. Supplementary Fig. S3: Circos plot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e66069dde343fc00689de337b82a9f
https://doi.org/10.1158/1078-0432.22459203
https://doi.org/10.1158/1078-0432.22459203
Autor:
Carsten Müller-Tidow, Wolfgang E. Berdel, Stefan Burdach, Heribert Jürgens, Daniel Baumhoer, Claudia Rossig, Eva Wardelmann, Wolfgang Hartmann, Gabriele Köhler, Monika Stoll, Anika Witten, Regina Besoke, Isabell Schulze, Matthias Weckesser, Thorsten Buch, Eberhard Korsching, Kathrin Poos, Martin Dugas, Udo Kontny, Hans-Ulrich Klein, Benjamin Moser, Kristina von Heyking, Uta Dirksen, Eva Schmidt, Günther H.S. Richter, Konstantin Agelopoulos
Supplementary Materials. Additional Material and Methods section and clinical data of the Ponatib treated patient.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac54f5bd1e6ce2e1cfd6c1992425a06
https://doi.org/10.1158/1078-0432.22459200
https://doi.org/10.1158/1078-0432.22459200
Autor:
Carsten Müller-Tidow, Wolfgang E. Berdel, Stefan Burdach, Heribert Jürgens, Daniel Baumhoer, Claudia Rossig, Eva Wardelmann, Wolfgang Hartmann, Gabriele Köhler, Monika Stoll, Anika Witten, Regina Besoke, Isabell Schulze, Matthias Weckesser, Thorsten Buch, Eberhard Korsching, Kathrin Poos, Martin Dugas, Udo Kontny, Hans-Ulrich Klein, Benjamin Moser, Kristina von Heyking, Uta Dirksen, Eva Schmidt, Günther H.S. Richter, Konstantin Agelopoulos
Purpose: A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9955f34fc024c4c397cbadc4c48654
https://doi.org/10.1158/1078-0432.c.6524157.v1
https://doi.org/10.1158/1078-0432.c.6524157.v1
Autor:
Carsten Müller-Tidow, Wolfgang E. Berdel, Stefan Burdach, Heribert Jürgens, Daniel Baumhoer, Claudia Rossig, Eva Wardelmann, Wolfgang Hartmann, Gabriele Köhler, Monika Stoll, Anika Witten, Regina Besoke, Isabell Schulze, Matthias Weckesser, Thorsten Buch, Eberhard Korsching, Kathrin Poos, Martin Dugas, Udo Kontny, Hans-Ulrich Klein, Benjamin Moser, Kristina von Heyking, Uta Dirksen, Eva Schmidt, Günther H.S. Richter, Konstantin Agelopoulos
Supplementary Tables S1-6. Table S1: Validation of somatic mutations by Sanger sequencing for construction of ROC Table S2: Characteristics of the discovery data set for exome sequencing Table S3: Somatic mutations in the discovery data set (filtered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d11955cccbf221f514772713b440c3
https://doi.org/10.1158/1078-0432.22459197
https://doi.org/10.1158/1078-0432.22459197