Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kristina Xiao Liang"'
Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids
Autor:
Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth John Sullivan, Charalampos Tzoulis, Laurence A. Bindoff, Kristina Xiao Liang
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract In this research, a 3D brain organoid model is developed to study POLG‐related encephalopathy, a mitochondrial disease stemming from POLG mutations. Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utili
Externí odkaz:
https://doaj.org/article/c1091475b6fa4da18c0883fa0bf68dff
Autor:
Anbin Chen, Cecilie Katrin Kristiansen, Yu Hong, Atefeh Kianian, Evandro Fei Fang, Gareth John Sullivan, Jian Wang, Xingang Li, Laurence A. Bindoff, Kristina Xiao Liang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria occur in several neurodeg
Externí odkaz:
https://doaj.org/article/2a4dff71cdaf47aab7ed7d5d5242e062
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Ferroptosis is a newly identified form of regulated cell death that is associated with iron metabolism and oxidative stress. As a physiological mechanism, ferroptosis selectively removes cancer cells by regulating the expression of vital chemical mol
Externí odkaz:
https://doaj.org/article/a364b115bde74275b1e78c6d705b5ee8
Autor:
Kristina Xiao Liang, Cecilie Katrin Kristiansen, Sepideh Mostafavi, Guro Helén Vatne, Gina Alien Zantingh, Atefeh Kianian, Charalampos Tzoulis, Lena Elise Høyland, Mathias Ziegler, Roberto Megias Perez, Jessica Furriol, Zhuoyuan Zhang, Novin Balafkan, Yu Hong, Richard Siller, Gareth John Sullivan, Laurence A Bindoff
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carryi
Externí odkaz:
https://doaj.org/article/dfb26524884144999cd67cac00ad6106
Autor:
Anbin Chen, Cecilie Katrin Kristiansen, Lena Elise Høyland, Mathias Ziegler, Jian Wang, Gareth John Sullivan, Xingang Li, Laurence A. Bindoff, Kristina Xiao Liang
Publikováno v:
Cell Cycle
We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD+/NADH ratio in both neural stem cells (
Autor:
Yu Hong, Cecilie Katrin Kristiansen, Anbin Chen, Gonzalo S. Nido, Lena Elise Høyland, Mathias Ziegler, Gareth John Sullivan, Laurence A. Bindoff, Kristina Xiao Liang
Publikováno v:
Experimental Neurology
Diseases caused byPOLGmutations are the most common form of mitochondrial disease and associated with phenotypes of varying severity. Clinical studies have shown that patients with compound heterozygousPOLGmutations have a lower survival rate than pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d0b2efc307c27c1095b66910f19325
https://doi.org/10.1101/2023.01.28.526021
https://doi.org/10.1101/2023.01.28.526021
Autor:
Lin Zhao, Han Wang, Sijia Liu, Tao Xi, Liyuan Wang, Yang Li, Lu Chen, Ruan Jianping, Kristina Xiao Liang
Publikováno v:
e23280
Journal of biochemical and molecular toxicology
Journal of biochemical and molecular toxicology
Excessive fluoride affects ameloblast differentiation and tooth development. The fate of fluorinated ameloblasts is determined by multiple signaling pathways in response to a range of stimuli. Both autophagy and apoptosis are involved in the regulati
Publikováno v:
Journal of Visualized Experiments.
Mitochondria are important in the pathophysiology of many neurodegenerative diseases. Changes in mitochondrial volume, mitochondrial membrane potential (MMP), mitochondrial production of reactive oxygen species (ROS), and mitochondrial DNA (mtDNA) co
Autor:
Tao Xi, Jiali Su, Kristina Xiao Liang, Sijia Liu, Yang Li, Lin Zhao, Jianping Ruan, Ruizhe Huang
Publikováno v:
Biochemical and Biophysical Research Communications-BBRC
Background Dental fluorosis is characterized by hypomineralization of tooth enamel caused by ingestion of excessive fluoride during enamel formation. Excess fluoride could have effects on the ERK signaling, which is essential for the ameloblasts diff
Autor:
Cecilie Katrin Kristiansen, Kristina Xiao Liang, Jessica Furriol, Anbin Chen, Mathias Ziegler, Atefeh Kianian, Laurence A. Bindoff, Gareth J. Sullivan, Yu Hong, Charalampos Tzoulis, Lena Elise Høyland, Torbjørn Kråkenes
The inability to reliably replicate mitochondrial DNA (mtDNA) by mitochondrial DNA polymerase gamma (POLG) leads to a subset of common mitochondrial diseases associated with neuronal death and depletion of neuronal mtDNA. Defining disease mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f8b26c2ad8474fc2a729caf204131e0
https://doi.org/10.1101/2020.12.20.423652
https://doi.org/10.1101/2020.12.20.423652