Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kristina Xega"'
Autor:
Yuhong Zhang, Akito Nakamura, Keli Song, Stephen Grossman, Kristina Xega, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/f03ad2073dd44c508bc2e84bcae80caa
Autor:
David T. Ting, Ben S. Wittner, Matteo Ligorio, Nicole Vincent Jordan, Ajay M. Shah, David T. Miyamoto, Nicola Aceto, Francesca Bersani, Brian W. Brannigan, Kristina Xega, Jordan C. Ciciliano, Huili Zhu, Olivia C. MacKenzie, Julie Trautwein, Kshitij S. Arora, Mohammad Shahid, Haley L. Ellis, Na Qu, Nabeel Bardeesy, Miguel N. Rivera, Vikram Deshpande, Cristina R. Ferrone, Ravi Kapur, Sridhar Ramaswamy, Toshi Shioda, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1905-1918 (2014)
Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define their composition, we compared genome-wide expression profiles of CTCs with matched primary tum
Externí odkaz:
https://doaj.org/article/f5cf1b8ba84846e2813882d89a5bd95d
Autor:
Akito Nakamura, Stephen Grossman, Keli Song, Kristina Xega, Yuhong Zhang, Donna Cvet, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Blood. 139(18)
Small ubiquitin-like modifier (SUMO) is a member of a ubiquitin-like protein superfamily. SUMOylation is a reversible posttranslational modification that has been implicated in the regulation of various cellular processes including inflammatory respo
Autor:
Keli Song, James Minissale, Richard A. Klinghoffer, James Garnsey, Katherine Galvin, Kristina Xega, Sai M Pulukuri, James M. Gavin, Xiaofeng Yang, Pooja Shah, Gary Shapiro, Cong Li, Vaishali Shinde, Eric S. Lightcap, Dennis Huszar, Zhen Lu, Stephen Grossman, Erik Koenig, Pengfei Yu, Steve Langston, Hisashi Imaichi, Serge Y. Fuchs, Mithun Khattar, Beryl A. Hatton, Yu Fu, Hongru Zhang, Dylan England, Michael Milhollen, Jessica Riceberg, Xingyue He
Publikováno v:
Sci Transl Med
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small molecule inhibitor of SUMOylation, pharmacologi
Autor:
Akito Nakamura, Keli Song, Stephen Grossman, Kristina Xega, Yuhong Zhang, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background TAK-981 is a first-in-class small molecule inhibitor of the SUMO activating enzyme in Phase 1 clinical trials. SUMOylation has previously been implicated in the regulation of innate immune responses and expression of Type I interferons,1 a
Autor:
Murat Karabacak, Leah J. Damon, Andrew S. Liss, Jackson P. Fatherree, Richard Y. Ebright, Rushil Desai, Robert Morris, Daniel A. Haber, Mauro Di Pilato, Francesca Bersani, Jose Malagon-Lopez, Anupriya S. Kulkarni, Eric Tai, Nicole Vincent Jordan, Julia Philipp, Melissa Choz, A. W. K. Liu, Vikram Deshpande, Kristina Xega, Miguel Rivera, Joseph W. Franses, Johannes Kreuzer, Cyril H. Benes, Myriam Boukhali, Martin J. Aryee, Kevin D. Vo, Oliver Schilling, Francesco Marangoni, Matteo Ligorio, Adam Langenbucher, Sandra Misale, Srinjoy Sil, Michael S. Lawrence, Kshitij S. Arora, Wilhelm Haas, Linda T. Nieman, Vishal Thapar, Mihir Rajurkar, Chittampalli Yashaswini, Carlos Fernandez-del-Castillo, Cristina R. Ferrone, Niyati Desai, Elad Horwitz, David T. Ting, Shyamala Maheswaran, Ulrich F. Wellner, Neelima K.C. Magnus, Azfar Neyaz
Publikováno v:
Cell
Cell, vol 178, iss 1
Cell, vol 178, iss 1
Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. Combining single-cell RNA and protein analytics in studying the role of stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8f16847960fab080e82c78f98d5029
http://hdl.handle.net/2318/1794764
http://hdl.handle.net/2318/1794764
Autor:
Abraham R. Tzafriri, Bryan C. Fuchs, Vikram Deshpande, Laura Indolfi, Cristina R. Ferrone, Robert Langer, Elazer R. Edelman, Vishal Thapar, Aaron B. Baker, Francesca Bersani, Daniel A. Haber, Kristina Xega, Jeffrey W. Clark, David T. Ting, Matteo Ligorio, Nicola Aceto
Publikováno v:
Biomaterials
PMC
PMC
Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing tr
Autor:
Sridhar Ramaswamy, David T. Ting, Shyamala Maheswaran, Kristina Xega, Daniel A. Haber, Olivia C. MacKenzie, Mingzhu Liu, Peter J. Park, Peter V. Kharchenko, Francesca Bersani, Hyunchul Jung, Eunjung Lee, Ben S. Wittner, Andrew Wei Xu, Brian W. Brannigan
Publikováno v:
Proceedings of the National Academy of Sciences. 112:15148-15153
Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon ca
Autor:
Miguel Rivera, Cyril H. Benes, Melissa Choz, Matteo Ligorio, Carlos Fernandez-del Castillo, Julia Philipp, Vikram Deshpande, Shyamala Maheswaran, Linda T. Nieman, Mihir Rajurkar, Francesca Bersani, Eric Tai, Vishal Thapar, Jose Malagon-Lopez, Joseph W. Franses, Daniel A. Haber, Nicole Vincent Jordan, Mauro Di Pilato, Leah J. Damon, Martin J. Aryee, Kevin D. Vo, Kristina Xega, Anupriya S. Kulkarni, Chittampalli Yashaswini, Johannes Kreuzer, Myriam Boukhali, Srinjoy Sil, Robert Morris, Cristina R. Ferrone, Kshitij S. Arora, David T. Ting, Niyati Desai, Wilhelm Haas, Murat Karabacak, Jackson P. Fatherree, Richard Y. Ebright, Rushil Desai, Sandra Misale, Francesco Marangoni
Publikováno v:
SSRN Electronic Journal.
Single cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single cell phenotypes have not been well defined. Combining single cell RNA and protein analytics in pancreatic cancer (PDAC) mo
Autor:
Vikram Deshpande, Kshitij S. Arora, Olivia C. MacKenzie, Haley Ellis, Miguel Rivera, Daniel A. Haber, Huili Zhu, David T. Miyamoto, Mohammad Shahid, Sridhar Ramaswamy, Ben S. Wittner, Jordan C. Ciciliano, Francesca Bersani, Matteo Ligorio, Ajay Shah, David T. Ting, Ravi Kapur, Toshi Shioda, Shyamala Maheswaran, Kristina Xega, Cristina R. Ferrone, Brian W. Brannigan, Nabeel Bardeesy, Mehmet Toner, Nicole Vincent Jordan, Na Qu, Julie Trautwein, Nicola Aceto
Publikováno v:
Cell reports
Cell Reports, Vol 8, Iss 6, Pp 1905-1918 (2014)
Cell Rep
Cell Reports, Vol 8, Iss 6, Pp 1905-1918 (2014)
Cell Rep
SUMMARY Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define their composition, we compared genome-wide expression profiles of CTCs with matched pri