Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kristina Sepčič"'
Autor:
Andrea Defant, Giacomo Carloni, Nicole Innocenti, Tomaž Trobec, Robert Frangež, Kristina Sepčić, Ines Mancini
Publikováno v:
Marine Drugs, Vol 22, Iss 4, p 173 (2024)
In this study, Antarctic Latrunculia sponge-derived discorhabdin G was considered a hit for developing potential lead compounds acting as cholinesterase inhibitors. The hypothesis on the pharmacophore moiety suggested through molecular docking allowe
Externí odkaz:
https://doaj.org/article/e1547d66855d4e57bae55098d2f07b44
Autor:
Anastasija Panevska, Nastja Čegovnik, Klavdija Fortuna, Alen Vukovič, Maja Grundner, Špela Modic, Gregor Bajc, Matej Skočaj, Martina Mravinec Bohte, Lara Larisa Popošek, Primož Žigon, Jaka Razinger, Peter Veranič, Nataša Resnik, Kristina Sepčić
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract An aegerolysin protein ostreolysin A6 (OlyA6) binds to cholesterol-complexed sphingomyelin and can be used for specific labelling of lipid rafts. In addition, OlyA6 interacts with even higher affinity with ceramide phosphoethanolamine (CPE),
Externí odkaz:
https://doaj.org/article/82419c3f3a524c84a35428cb9bf587d7
Autor:
Monika Novak Babič, Sara Ragucci, Adrijana Leonardi, Miha Pavšič, Nicola Landi, Igor Križaj, Nina Gunde-Cimerman, Kristina Sepčić, Antimo Di Maro
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 336 (2024)
Sodin 5 is a type 1 ribosome-inactivating protein isolated from the seeds of Salsola soda L., an edible halophytic plant that is widespread in southern Europe, close to the coast. This plant, known as ‘agretti’, is under consideration as a new po
Externí odkaz:
https://doaj.org/article/1591c3bda9f7450598abeb486d847a44
Autor:
Larisa Lara Popošek, Nada Kraševec, Gregor Bajc, Urška Glavač, Matija Hrovatin, Žan Perko, Ana Slavič, Miha Pavšič, Kristina Sepčić, Matej Skočaj
Publikováno v:
Toxins, Vol 16, Iss 3, p 143 (2024)
Aegerolysins are a family of proteins that recognize and bind to specific membrane lipids or lipid domains; hence they can be used as membrane lipid sensors. Although aegerolysins are distributed throughout the tree of life, the most studied are thos
Externí odkaz:
https://doaj.org/article/ea50dd2ff5984ad0b2c876a2eb97d8fc
Autor:
Nataša Resnik, Diana Baraga, Polona Glažar, Špela Jokhadar Zemljič, Jure Derganc, Kristina Sepčić, Peter Veranič, Mateja Erdani Kreft
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tunnelling nanotubes (TNTs) are membranous connections that represent a unique type of intercellular communication in different cell types. They are associated with cell physiology and cancer pathology. The possible existence of tunnelling nanotubes
Externí odkaz:
https://doaj.org/article/a0dd0a293b00424faf76e27e3fe26eef
Autor:
Teresa Balbi, Francesco Trenti, Anastasija Panevska, Gregor Bajc, Graziano Guella, Caterina Ciacci, Barbara Canonico, Laura Canesi, Kristina Sepčić
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Ostreolysin A6 (OlyA6) is a 15 kDa protein produced by the oyster mushroom (Pleurotus ostreatus). It belongs to the aegerolysin family of proteins and binds with high affinity to the insect-specific membrane sphingolipid, ceramide phosphoethanolamine
Externí odkaz:
https://doaj.org/article/4f67be9873184392940110b3c69e39a6
Autor:
Eva Kočar, Tea Lenarčič, Vesna Hodnik, Anastasija Panevska, Yunjie Huang, Gregor Bajc, Rok Kostanjšek, Anjaparavanda P. Naren, Peter Maček, Gregor Anderluh, Kristina Sepčić, Marjetka Podobnik, Matej Butala
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Aegerolysins are proteins produced by bacteria, fungi, plants and protozoa. The most studied fungal aegerolysins share a common property of interacting with membranes enriched with cholesterol in combination with either sphingomyelin or cera
Externí odkaz:
https://doaj.org/article/bf82f07acaef4c448d00464a1303d152
Autor:
Jakob Kljun, Mihaela Rebernik, Lucía M. Balsa, Jerneja Kladnik, Uroš Rapuš, Tomaž Trobec, Kristina Sepčić, Robert Frangež, Ignacio E. León, Iztok Turel
Publikováno v:
Molecules, Vol 28, Iss 6, p 2499 (2023)
Organoruthenium pyrithione (1-hydroxypyridine-2-thione) complexes have been shown in our recent studies to be a promising family of compounds for development of new anticancer drugs. The complex [(η6-p-cymene)Ru(pyrithionato)(pta)]PF6 contains phosp
Externí odkaz:
https://doaj.org/article/0bf0627171a9456fb44468bc7d49c0e4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2681 (2023)
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after progression of Alzheimer’s disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. The organoruth
Externí odkaz:
https://doaj.org/article/aa493d1152a64e99b827724bfcf355a0
Autor:
Homayon John Arabshahi, Tomaž Trobec, Valentin Foulon, Claire Hellio, Robert Frangež, Kristina Sepčić, Patrick Cahill, Johan Svenson
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
The search for effective yet environmentally friendly strategies to prevent marine biofouling is hampered by the large taxonomic diversity amongst fouling organisms and a lack of well-defined conserved molecular targets. The acetylcholinesterase enzy
Externí odkaz:
https://doaj.org/article/4c10ee8a69fe4884bd77e2e313146320