Výsledky vyhledávání - "Kristina S. Vikman"

Interferon-γ induced disruption of GABAergic inhibition in the spinal dorsal horn in vivo

Autor: Kristina S. Vikman, Philip J. Siddall, Arthur W. Duggan

Publikováno v: Pain. 133:18-28

The proinflammatory cytokine interferon-gamma (IFN-gamma), which can be present in elevated levels in the central nervous system during pathological conditions, may be involved in the generation of persistent pain states by inducing neuronal hyperexc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58af6b6ea34e9121f0379646684bb6d5
https://doi.org/10.1016/j.pain.2007.02.010

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Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn

Autor: MacDonald J. Christie, Kristina S. Vikman, Beth K. Rycroft

Publikováno v: The Journal of Physiology. 580:883-894

N-type calcium channels contribute to the release of glutamate from primary afferent terminals synapsing onto nocisponsive neurons in the dorsal horn of the spinal cord, but little is known of functional adaptations to these channels in persistent pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fed19655f47db1fbb8a47771cc7f72c2
https://doi.org/10.1113/jphysiol.2006.125880

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Interferon-γ-induced changes in synaptic activity and AMPA receptor clustering in hippocampal cultures

Autor: Krister Kristensson, Johan Brask, Russell H. Hill, Kristina S. Vikman, Björn Owe-Larsson

Publikováno v: Brain Research. 896:18-29

Extended release of interferon-gamma (IFN-gamma) in the nervous system during immunological and infectious conditions may trigger demyelinating disorders and cause disturbances in brain function. The aim of this study was to examine the effects of IF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387e4e532ab3f66bc07fe9d5755de36c
https://doi.org/10.1016/s0006-8993(00)03238-8

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[Untitled]

Autor: Kristina S. Vikman, Anders Liljeborg, Brita Robertson, Krister Kristensson, Gunnar Grant

Publikováno v: Journal of Neurocytology. 27:749-760

Summary Interferon-γ can facilitate the spinal nociceptive flexor reflex and elicit neuropathic pain-related behavior in rats and mice. Immunoreactivity for the interferon-γ receptor (IFN-γR) occurs in the superficial layers of the dorsal horn and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::073388541caefcbe49c588c2489fcd04
https://doi.org/10.1023/a:1006903002044

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Switch to Ca2+-permeable AMPA and reduced NR2B NMDA receptor-mediated neurotransmission at dorsal horn nociceptive synapses during inflammatory pain in the rat

Autor: Kristina S, Vikman, Beth K, Rycroft, Macdonald J, Christie

Publikováno v: The Journal of physiology. 586(2)

Glutamate receptor response properties of nociceptive synapses on neurokinin 1 receptor positive (NK1R+) lamina I neurons were determined 3 days after induction of chronic peripheral inflammation with Freund's Complete Adjuvant (CFA). A significant i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54137c69ea971ebc6c6d5f5fffb5a48e
https://pubmed.ncbi.nlm.nih.gov/18033811

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Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn

Autor: Beth K, Rycroft, Kristina S, Vikman, MacDonald J, Christie

Publikováno v: The Journal of physiology. 580(Pt.3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a755c2a2cc13ebc370e48a657a5b926
https://pubmed.ncbi.nlm.nih.gov/17303639

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Increased responsiveness of rat dorsal horn neurons in vivo following prolonged intrathecal exposure to interferon-gamma

Autor: Arthur W. Duggan, Philip J. Siddall, Kristina S. Vikman

Publikováno v: Neuroscience. 135(3)

Prolonged increases in the level of the pro-inflammatory cytokine interferon-gamma occur in the CNS during some disease states associated with persistent pain. Administration of interferon-gamma to both humans and rodents has produced pain or pain-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63028c876bc461a6704b9472ddb67ced
https://pubmed.ncbi.nlm.nih.gov/16125859

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Interferon-gamma induces characteristics of central sensitization in spinal dorsal horn neurons in vitro

Autor: Krister Kristensson, Kristina S. Vikman, Russell H. Hill, Eva Backström, Brita Robertson

Publikováno v: PainReferences. 106(3)

Hyperexcitability of spinal dorsal horn neurons, also known as 'central sensitization', is a component of pain associated with pathological conditions in the nervous system. The aim of the present study was to analyze if the pro-inflammatory cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ff5c2dcc4ad89017d517eb50cc5d93
https://pubmed.ncbi.nlm.nih.gov/14659507

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Increased ability to induce long-term potentiation of spinal dorsal horn neurones in monoarthritic rats

Autor: Philip J. Siddall, Arthur W. Duggan, Kristina S. Vikman

Publikováno v: Brain research. 990(1-2)

Long-term potentiation (LTP) of transmission of impulses in unmyelinated (C-fibre) primary afferents by prior tetanic conditioning stimulation has been demonstrated in the dorsal horn of the spinal cord. Since this potentiation has been proposed to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82d1262b94479b63df50ca7ce1f2025
https://pubmed.ncbi.nlm.nih.gov/14568329

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