Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kristina S. Kovacina"'
Autor:
Rong Xie, Weiying Xie, Heng Zhao, Michelle Y. Cheng, Kristina S. Kovacina, Hong-Fei Zhang, Lijuan Gu, Xiaoxing Xiong, Zhihong Jian
Publikováno v:
Neurobiology of Disease, Vol 66, Iss, Pp 43-52 (2014)
The proline-rich Akt substrate of 40 kDa (PRAS40) protein is not only a substrate of the protein kinase Akt but also a component of the mTOR complex 1 (mTORC1), thus it links the Akt and the mTOR pathways. We investigated the potential protective rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33137cf10b589a8316644f8ff8fabcf6
http://www.sciencedirect.com/science/article/pii/S0969996114000485
http://www.sciencedirect.com/science/article/pii/S0969996114000485
Autor:
Marco Conti, Taku Nedachi, Seung Jin Han, Richard A. Roth, Sergio Vaccari, Carsten B Andersen, Kristina S. Kovacina
Publikováno v:
The EMBO Journal. 25:5716-5725
cGMP-inhibited cAMP phosphodiesterase 3A (PDE3A) is expressed in mouse oocytes, and its function is indispensable for meiotic maturation as demonstrated by genetic ablation. Moreover, PDE3 activity is required for insulin/insulin-like growth factor-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7a176a06ef0f2050183da7552354ba
https://doi.org/10.1038/sj.emboj.7601431
https://doi.org/10.1038/sj.emboj.7601431
Publikováno v:
Journal of Biological Chemistry. 279:55277-55282
Although a number of studies and approaches have indicated that activation of the Ser/Thr kinase called Akt/protein kinase B is critical for the insulin-stimulated increase of glucose uptake in adipocytes, other studies have indicated that this enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0924deabc09dfc26e3dd4290e7190e9e
https://doi.org/10.1074/jbc.m411540200
https://doi.org/10.1074/jbc.m411540200
Autor:
Andrew W. Guzzetta, Morris J. Birnbaum, Erik Schaefer, Grace Y. Park, Kristina S. Kovacina, Sun Sik Bae, Richard A. Roth
Publikováno v:
Journal of Biological Chemistry. 278:10189-10194
Akt (also called protein kinase B) is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway. This protein kinase has been implicated in insulin signaling, stimulation of cellular growth, and inhibition of apoptosis as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3870d0af0143ab81b0874cff2a1eb32
https://doi.org/10.1074/jbc.m210837200
https://doi.org/10.1074/jbc.m210837200
Autor:
Taku Nedachi, Hiroshi Sakaue, Carsten B Andersen, Richard A. Roth, Marco Conti, Carol Clayberger, Kristina S. Kovacina
Publikováno v:
Biochemical Journal. 369:227-238
In the present study, we have characterized the Xenopus Akt expressed in oocytes from the African clawed frog Xenopus laevis and tested whether its activity is required for the insulin- and progesterone-stimulated resumption of meiosis. A cDNA encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583fafd791beb57ab14fab5b6a437f22
https://doi.org/10.1042/bj20021243
https://doi.org/10.1042/bj20021243
Publikováno v:
Journal of Biological Chemistry. 276:8073-8078
The pleckstrin homology (PH) domain of the insulin receptor substrate-1 (IRS-1) plays a role in directing this molecule to the insulin receptor, thereby regulating its tyrosine phosphorylation. In this work, the role of the PH domain in subsequent si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6a6732d1137c73eadc3fbf4c2d3d33
https://doi.org/10.1074/jbc.m008436200
https://doi.org/10.1074/jbc.m008436200
Autor:
Brenda J. Wallach, John C. Lawrence, Annegret Boge, Kristina S. Kovacina, Andreas Barthel, Scott A. Summers, Morris J. Birnbaum, Aimee D. Kohn, Richard A. Roth, Pamela H. Scott
Publikováno v:
Journal of Biological Chemistry. 273:11937-11943
Akt is a serine/threonine kinase that requires a functional phosphatidylinositol 3-kinase to be stimulated by insulin and other growth factors. When directed to membranes by the addition of a src myristoylation sequence, Akt becomes constitutively ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591581ed07706b3585733f320d7ef5d1
https://doi.org/10.1074/jbc.273.19.11937
https://doi.org/10.1074/jbc.273.19.11937
Publikováno v:
The EMBO Journal. 14:4288-4295
In the present study, insulin is shown to rapidly stimulate by 8- to 12-fold the enzymatic activity of RAC-PK alpha, a pleckstrin homology domain containing ser/thr kinase. In contrast, activation of protein kinase C by phorbol esters had almost no e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b2bcbbb690849906e8d112bb597099
https://doi.org/10.1002/j.1460-2075.1995.tb00103.x
https://doi.org/10.1002/j.1460-2075.1995.tb00103.x
Autor:
Richard A. Roth, Kristina S. Kovacina
Publikováno v:
Biochemical and Biophysical Research Communications. 192:1303-1311
Insulin stimulated tyrosine phosphorylation of SHC, a SH2 containing protein, was demonstrated in Chinese hamster ovary cellsoverexpressing the insulin receptor by immunoblotting with antiphosphotyrosine antibodies and in vivo labeling. Insulin induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365b117e7c5f38afc7fde131dcece226
https://doi.org/10.1006/bbrc.1993.1558
https://doi.org/10.1006/bbrc.1993.1558
Autor:
Hans Marquardt, Kristina S. Kovacina, Linda Madisen, Mario N. Lioubin, Richard A. Roth, A.F. Purchio
Publikováno v:
Journal of Cellular Biochemistry. 45:112-121
Latent recombinant transforming growth factor-beta 2 (LrTGF-beta 2) complex has been purified from serum-free media conditioned by Chinese hamster ovary cells transfected with a plasmid encoding the TGF-beta 2 (414) precursor. Under neutral condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305755a92b86b839d40b80ba0d7c09a0
https://doi.org/10.1002/jcb.240450118
https://doi.org/10.1002/jcb.240450118