Vascular Cognitive Impairment Linked to Brain Endothelium Inflammation in Early Stages of Heart Failure in Mice

Autor: Mateusz G. Adamski, Magdalena Sternak, Tasnim Mohaissen, Dawid Kaczor, Joanna M. Wierońska, Monika Malinowska, Iwona Czaban, Katarzyna Byk, Kristina S. Lyngsø, Kamil Przyborowski, Pernille B.L. Hansen, Grzegorz Wilczyński, Stefan Chlopicki

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 7 (2018)

BackgroundAlthough advanced heart failure (HF) is a clinically documented risk factor for vascular cognitive impairment, the occurrence and pathomechanisms of vascular cognitive impairment in early stages of HF are equivocal. Here, we characterize va

Externí odkaz: https://doaj.org/article/b7c4a58aea5d4c42b9545c59acc5bee1

Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice

Autor: Kristina S. Lyngsø, Charlotte Brasch-Andersen, Kenneth Andersen, Anne D Thuesen, Pernille B. Lærkegaard Hansen, Paul M. Vanhoutte, Mark Burton

Publikováno v: Thuesen, A D, Andersen, K, Lyngsø, K S, Burton, M, Brasch-Andersen, C, Vanhoutte, P M & Hansen, P B L 2018, ' Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice ', Pflügers Archiv-European Journal of Physiology, vol. 470, no. 2, pp. 355–365 . https://doi.org/10.1007/s00424-017-2068-x

Impairment of endothelial function with aging is accompanied by reduced nitric oxide (NO) production. T-type Cav3.1 channels augment nitric oxide and co-localize with eNOS. Therefore, the hypothesis was that T-type channels contribute to the endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b57d99a931ecc462a63bab01ffa98b
https://doi.org/10.1007/s00424-017-2068-x

Fumarate decreases edema volume and improves functional outcome after experimental stroke

Autor: Kate Lykke Lambertsen, Helle Hvilsted Nielsen, Nellie Anne Martin, Pernille B. Lærkegaard Hansen, Bettina Hjelm Clausen, Tomas Deierborg, Martina Svensson, Antonio Boza-Serrano, Bente Finsen, Louise Lundberg, Zsolt Illes, Simon Bertram Flæng, Maria Zeiler Alfsen, Minna Liisa Kyllikki Yli-Karjanmaa, Kristina S. Lyngsø

Publikováno v: Clausen, B H, Lundberg, L, Yli-Karjanmaa, M L K, Martin, N A, Svensson, M, Zeiler Alfsen, M, Flæng, S B, Lyngsø, K S, Boza-Serrano, A, Nielsen, H H, Hansen, P B L, Finsen, B, Deierborg, T, Illés, Z & Lambertsen, K L 2017, ' Fumarate decreases edema volume and improves functional outcome after experimental stroke ', Experimental Neurology, vol. 295, pp. 144–154 . https://doi.org/10.1016/j.expneurol.2017.06.011

Background Oxidative stress and inflammation exacerbate tissue damage in the brain after ischemic stroke. Dimethyl-fumarate (DMF) and its metabolite monomethyl-fumarate (MMF) are known to stimulate anti-oxidant pathways and modulate inflammatory resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f13a15b2262f2a98590b8c04b7a0aa6
https://pubmed.ncbi.nlm.nih.gov/28602832

P/Q-type and T-type voltage-gated calcium channels are involved in the contraction of mammary and brain blood vessels from hypertensive patients

Autor: Ole Skøtt, Frantz Rom Poulsen, Jane Stubbe, Anne D Thuesen, Lotte Rasmussen, Kristina S. Lyngsø, Lars Melholt Rasmussen, Pernille B. Lærkegaard Hansen, Christian Bonde Pedersen

Publikováno v: Thuesen, A D, Lyngsø, K S, Rasmussen, L, Stubbe, J, Skøtt, O, Rom Poulsen, F, Pedersen, C B, Rasmussen, L M & Hansen, P B L 2017, ' P/Q-type and T-type voltage-gated calcium channels are involved in the contraction of mammary and brain blood vessels from hypertensive patients ', Acta Physiologica, vol. 219, no. 3, pp. 642–653 . https://doi.org/10.1111/apha.12732

AIM: Calcium channel blockers are widely used in cardiovascular diseases. Besides L-type channels, T- and P/Q-type calcium channels are involved in the contraction of human renal blood vessels. It was hypothesized that T- and P/Q-type channels are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4985cd90192094a1651d020aa64173f6
https://pubmed.ncbi.nlm.nih.gov/27273014