Výsledky vyhledávání - "Kristina Rochon"

Synthesis of Gly-ψ[(Z)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic

Autor: Guillaume Langlois, Louis Gendron, Sébastien Grastilleur, Thi Thanh Hà Dao, Brigitte Guérin, Véronique Blais, Kristina Rochon, Yves L. Dory, Jean-François Nadon

Publikováno v: ACS Chemical Neuroscience. 8:40-49

A new Leu-enkephalin peptidomimetic designed to explore the hydrogen bond acceptor ability of the third peptide bond has been prepared and studied. This new analog is produced by replacing the third amide of Leu-enkephalin with a fluoroalkene. An eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213e655ed804e39ebac11c2a1aa03778
https://doi.org/10.1021/acschemneuro.6b00163

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Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity

Autor: Pierre-Julien Albert, Louis Gendron, Arnaud Proteau-Gagné, Kristina Rochon, Yves L. Dory, Brigitte Guérin, Mélissa Roy

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:5267-5269

Using Cu(I)-catalyzed azide-alkyne cycloaddition in a mixed classical organic phase and solid phase peptide synthesis approach, we synthesized four analogs of Leu-enkephalin to systematically replace amides by 1,4-disubstituted[1,2,3]triazoles. The p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d790e3f483938a5159b1562203b89bb
https://doi.org/10.1016/j.bmcl.2013.08.020

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Preparation and evaluation at the delta opioid receptor of a series of linear leu-enkephalin analogues obtained by systematic replacement of the amides

Autor: Louis Gendron, Arnaud Proteau-Gagné, Jérôme Côté, Yves L. Dory, Jean-François Nadon, Véronique Bournival, Brigitte Guérin, Philippe Bourassa, Kristina Rochon, Fernand Gobeil

Publikováno v: ACS chemical neuroscience. 4(8)

Leu-enkephalin analogues, in which the amide bonds were sequentially and systematically replaced either by ester or N-methyl amide bonds, were prepared using classical organic chemistry as well as solid phase peptide synthesis (SPPS). The peptidomime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170b13efdf5e1cca89934ab224f5d804
https://pubmed.ncbi.nlm.nih.gov/23650868

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Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor

Autor: Véronique Bournival, Yves L. Dory, Louis Gendron, Arnaud Proteau-Gagné, Kristina Rochon

The role of each of the four amide bonds in Leu(5)-enkephalin was investigated by systematically and sequentially replacing each with its corresponding trans-alkene. Six Leu(5)-enkephalin analogs based on six dipeptide surrogates and two Met(5)-enkep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd1f2082ceee9bdbce8033a53dbc640
https://europepmc.org/articles/PMC3368656/

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