Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristina Rochon"'
Autor:
Guillaume Langlois, Louis Gendron, Sébastien Grastilleur, Thi Thanh Hà Dao, Brigitte Guérin, Véronique Blais, Kristina Rochon, Yves L. Dory, Jean-François Nadon
Publikováno v:
ACS Chemical Neuroscience. 8:40-49
A new Leu-enkephalin peptidomimetic designed to explore the hydrogen bond acceptor ability of the third peptide bond has been prepared and studied. This new analog is produced by replacing the third amide of Leu-enkephalin with a fluoroalkene. An eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213e655ed804e39ebac11c2a1aa03778
https://doi.org/10.1021/acschemneuro.6b00163
https://doi.org/10.1021/acschemneuro.6b00163
Autor:
Pierre-Julien Albert, Louis Gendron, Arnaud Proteau-Gagné, Kristina Rochon, Yves L. Dory, Brigitte Guérin, Mélissa Roy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5267-5269
Using Cu(I)-catalyzed azide-alkyne cycloaddition in a mixed classical organic phase and solid phase peptide synthesis approach, we synthesized four analogs of Leu-enkephalin to systematically replace amides by 1,4-disubstituted[1,2,3]triazoles. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d790e3f483938a5159b1562203b89bb
https://doi.org/10.1016/j.bmcl.2013.08.020
https://doi.org/10.1016/j.bmcl.2013.08.020
Autor:
Louis Gendron, Arnaud Proteau-Gagné, Jérôme Côté, Yves L. Dory, Jean-François Nadon, Véronique Bournival, Brigitte Guérin, Philippe Bourassa, Kristina Rochon, Fernand Gobeil
Publikováno v:
ACS chemical neuroscience. 4(8)
Leu-enkephalin analogues, in which the amide bonds were sequentially and systematically replaced either by ester or N-methyl amide bonds, were prepared using classical organic chemistry as well as solid phase peptide synthesis (SPPS). The peptidomime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170b13efdf5e1cca89934ab224f5d804
https://pubmed.ncbi.nlm.nih.gov/23650868
https://pubmed.ncbi.nlm.nih.gov/23650868
The role of each of the four amide bonds in Leu(5)-enkephalin was investigated by systematically and sequentially replacing each with its corresponding trans-alkene. Six Leu(5)-enkephalin analogs based on six dipeptide surrogates and two Met(5)-enkep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd1f2082ceee9bdbce8033a53dbc640
https://europepmc.org/articles/PMC3368656/
https://europepmc.org/articles/PMC3368656/
Autor:
Rochon, Kristina
Selon l'Organisation mondiale de la Santé, les médicaments les plus utilisés pour le soulagement des douleurs modérées à sévères demeurent les opioïdes. Toutefois, leur utilisation s'accompagne d'effets indésirables comme la nausée, la sé
Externí odkaz:
http://hdl.handle.net/11143/6355