Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristina Preuße"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Human nephrogenesis ends prior to birth in term infants (34–36 week gestation), with most (60%) nephrons forming in late gestation in two post-branching nephrogenesis (PBN) periods: arcading and lateral branch nephrogenesis. Preterm infant
Externí odkaz:
https://doaj.org/article/29efe9279d314dc4aa95c17a8b40d43e
Autor:
Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Praneet Chaturvedi, Sarah J Stein, Warren S Pear, Zhenyu Yuan, Rhett A Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric W Brunskill, Raphael Kopan
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Externí odkaz:
https://doaj.org/article/56bb8176d92c404f8da9d4b31d6102f3
Autor:
Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein
Publikováno v:
eLife, Vol 9 (2020)
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting
Externí odkaz:
https://doaj.org/article/d503de51d4de46d4b3e298e0644a7d3d
Autor:
Kristina Preuße, Lena Tveriakhina, Karin Schuster-Gossler, Cláudia Gaspar, Alexandra Isabel Rosa, Domingos Henrique, Achim Gossler, Michael Stauber
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005328 (2015)
Notch signalling is a fundamental pathway that shapes the developing embryo and sustains adult tissues by direct communication between ligand and receptor molecules on adjacent cells. Among the ligands are two Delta paralogues, DLL1 and DLL4, that ar
Externí odkaz:
https://doaj.org/article/2ffcaf61c0d248b7a18b07854ece2d6f
Autor:
Elisabet Johansson, Seth Jenkins, Raphael Kopan, Gurjit K. Khurana Hershey, Xiaoting Chen, Jocelyn M. Biagini, John Kroner, Hua He, Liza Bronner Murrison, Xiaomeng Ren, Lisa J. Martin, Matthew T. Weirauch, Kristina Preusse
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine important in initiation of allergic inflammation. Single nucleotide polymorphisms (SNPs) in TSLP are associated with asthma, yet studies have shown inconsistent associa
Autor:
Brian Gebelein, Zhenyu Yuan, Yi Kuang, Raphael Kopan, Matthew R. Hass, FearGod V Okwubido-Williams, Ohad Golan, Kristina Preusse, Joseph Salomone, Collin J Christensen, Brittany Cain, Rhett A. Kovall, David Sprinzak, Ian Campbell, Kenneth H. Moberg, Nathanel Eafergan
Publikováno v:
eLife, Vol 9 (2020)
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting
Autor:
Yi Kuang, Kristina Preusse, Matthew R. Hass, Ohad Golan, Ian Campbell, Zhenyu Yuan, David Sprinzak, Rhett A. Kovall, Raphael Kopan, Brittany Cain, Collin J Christensen, Brian Gebelein, Kenneth H. Moberg, FearGod V Okwubido-Williams, Nathanel Eafergan, Joseph Salomone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d808fd3b59b5e4b091bd358f10b40808
https://doi.org/10.7554/elife.53659.sa2
https://doi.org/10.7554/elife.53659.sa2
Autor:
Raphael Kopan, Brian Gebelein, Francis M. Kobia, Sarah J. Stein, Rhett A. Kovall, Warren S. Pear, Kristina Preusse, Quanhui Dai, Yi Kuang, David Sprinzak, Natanel Eafergen, Eric W. Brunskill, Praneet Chaturvedi, Nicholas Weaver, Matthew R. Hass, Zhenyu Yuan
Publikováno v:
PLoS Biology
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
PLoS Biology, Vol 18, Iss 10, p e3000850 (2020)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Autor:
Francis M. Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Praneet Chaturvedi, Sarah J. Stein, Warren S. Pear, Zhenyu Yuan, Rhett A. Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric Brunskill, Raphael Kopan
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a8ebf6692c3d81de30f3c267edb9ec
Autor:
Yi, Kuang, Ohad, Golan, Kristina, Preusse, Brittany, Cain, Collin J, Christensen, Joseph, Salomone, Ian, Campbell, FearGod V, Okwubido-Williams, Matthew R, Hass, Zhenyu, Yuan, Nathanel, Eafergan, Kenneth H, Moberg, Rhett A, Kovall, Raphael, Kopan, David, Sprinzak, Brian, Gebelein
Publikováno v:
eLife
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting