Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kristina Pilvinyte"'
Autor:
Alvin Shrestha, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Avan A Sayer, Christos Rossios, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0307268 (2024)
IntroductionUnderstanding genetic contributors to sarcopenia (age-related loss of muscle strength and mass) is key to finding effective therapies. Variants of the bradykinin receptor 2 (BDKRB2) have been linked to athletic and muscle performance. The
Externí odkaz:
https://doaj.org/article/729f9642b39144fe86a84ce912c50d84
Autor:
The LACE study group, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M. Band, Tufail Bashir, Louise A. Burton, Vera Cvoro, Peter T. Donnan, Gordon W. Duncan, Jacob George, Adam L. Gordon, Celia L. Gregson, Adrian Hapca, Emily Henderson, Cheryl Hume, Thomas A. Jackson, Paul Kemp, Simon Kerr, Alixe Kilgour, Veronica Lyell, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C. Roberts, Christos Rossios, Avan A. Sayer, Karen T. Smith, Roy L. Soiza, Claire J. Steves, Allan D. Struthers, Deepa Sumukadas, Divya Tiwari, Julie Whitney, Miles D. Witham
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 858-871 (2022)
Abstract Background This trial aimed to determine the efficacy of leucine and/or perindopril in improving physical function in older people with sarcopenia. Methods Placebo‐controlled, parallel group, double‐blind, randomized two‐by‐two facto
Externí odkaz:
https://doaj.org/article/5f34d75a32554bc08ecdb7f05da3b12d
Autor:
Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Christos Rossios, Avan A Sayer, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294330 (2023)
BackgroundAgeing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass. Sarcopenia is characterised by losses in both muscle mass and strength. Body composition and muscl
Externí odkaz:
https://doaj.org/article/c30fb2aff4ea4c5a9943bf38e3bcd800
Autor:
Christos Rossios, Tufail Bashir, Marcus Achison, Simon Adamson, Asangaedem Akpan, Terry Aspray, Alison Avenell, Margaret M Band, Louise A Burton, Vera Cvoro, Peter T Donnan, Gordon W Duncan, Jacob George, Adam L Gordon, Celia L Gregson, Adrian Hapca, Cheryl Hume, Thomas A Jackson, Simon Kerr, Alixe Kilgour, Tahir Masud, Andrew McKenzie, Emma McKenzie, Harnish Patel, Kristina Pilvinyte, Helen C Roberts, Avan A Sayer, Karen T Smith, Roy L Soiza, Claire J Steves, Allan D Struthers, Divya Tiwari, Julie Whitney, Miles D Witham, Paul R Kemp
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292402 (2023)
BackgroundAngiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed t
Externí odkaz:
https://doaj.org/article/8651c39bcec645eeb9cc2a0bb488cd15
Autor:
Miles D. Witham, Marcus Achison, Terry J. Aspray, Alison Avenell, Margaret M. Band, Peter T. Donnan, Jacob George, Adrian Hapca, Cheryl Hume, Paul Kemp, Kristina Pilvinyte, Avan A. Sayer, Karen T. Smith, Allan D. Struthers, Deepa Sumukadas
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 93-102 (2021)
Abstract Background Sarcopenia is rarely diagnosed and is not recorded electronically in routine clinical care, posing challenges to trial recruitment. We describe the performance of four components of a strategy to efficiently recruit participants w
Externí odkaz:
https://doaj.org/article/e05c1ceddece461ba519a4e1b66344bf
Autor:
Miles D Witham, Simon Adamson, Alison Avenell, Margaret M Band, Tufail Bashir, Peter T Donnan, Jacob George, Adrian Hapca, Cheryl Hume, Paul Kemp, Emma McKenzie, Kristina Pilvinyte, Christos Rossios, Karen Smith, Allan D Struthers, Deepa Sumukadas
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 9, Iss 8 (2022)
Background: Angiotensin-converting enzyme inhibitors and leucine are promising potential treatments for sarcopenia. Neither has yet been tested in adequately powered randomised trials in patients with sarcopenia. Objectives: To determine the efficacy
Externí odkaz:
https://doaj.org/article/6cbf95e5be004745bf2b2a08f3047014
Autor:
Holly R Keir, Merete B Long, Hani Abo-Leyah, Yan Hui Giam, Thenmalar Vadiveloo, Thomas Pembridge, Rebecca C Hull, Lilia Delgado, Margaret Band, Fiona McLaren-Neil, Simon Adamson, Eva Lahnsteiner, Amy Gilmour, Chloe Hughes, Benjamin JM New, David Connell, Rebecca Dowey, Helena Turton, Hollian Richardson, Diane Cassidy, Jamie Cooper, Jay Suntharalingam, Lavanya Diwakar, Peter Russell, Jonathan Underwood, Alexander Hicks, Davinder PS Dosanjh, Beth Sage, Devesh Dhasmana, Mark Spears, AA Roger Thompson, Christopher Brightling, Andrew Smith, Manish Patel, Jacob George, Alison M Condliffe, Amelia Shoemark, Graeme MacLennan, James D Chalmers, James Chalmers, Christine Almaden-Boyle, Jennifer Taylor, Jodie Strachan, Heather Loftus, Lesley Young, Angela Strachan, Kristina Pilvinyte, Petra Rauchhaus, Fiona Hogarth, Tricia Burns, Elizabeth Coote, Marney Keiller, Elizabeth Sage, David Miller, Davinder Dosanjh, Benjamin Sutton, Sharon Frayling, Matthew Haynes, Lauren Broad, Laura Jones, Karen Rahilly, Catherine Oliver, Terriann Evans, Andrea Balan, Rhys Davies, Donal Forde, Clemency Nye, Dr Haboubi, Zoe Hilton, Jennie Williams, Alison McQueen, Ian Edmond, Dario Salutous, Laura McGenily, Rhona Scott, Eilidh Henderson, Andrea Collins, Patrick Liu, Ana Morrow, Mandy Couser, Fleur Davey, Laura Wiffen, Lauren Fox, Mohamed Abdelrahim, Alexander Darbyshire, Elena Cowen, Megan Rowley, Benjamin Giles, Yingjia Yang, Tom Brown, Hitasha Rupani, Elizabeth Hawes, Debi Barnes, Fiona Brogan, Roneleeh Bungue-Tuble, Serena Howe, Charlotte Turner, Sonia Baryschpolec, Bev Longhurst, Maria Moon, Lynn Watkins, Michelle Baker-Moffat, Lisa Murray, Yasmin Harrington-Davies, Kate Burrows, Chrissie Minnis, Mary Wands, Adefunke Bamgboye, Charlotte Wong, Sarah Diver, Richard Russell, Hamish McAuley, Omer Elneima, Ahmed Yousuf, Paula McCourt, Beverley Hargadon, Sarah Parker, Michelle Bourne, Tom Hartley, Vidan Masan, Sharon Sturney, Rob MacKenzie, Clare Marchand, Rebecca Mason, Katie White, Alison Kirby, Manjula Meda, Joanne Finn, Sophie Harris, Carol Muir, Gemma Cook, Nikki Staines, Chris Cook, Alison Condliffe, Rebecca Hull, Paul Collini, Zoé Gabriel, Simon Hardman, Helen Newell, Janet Middle, Phillip Simpson, Hayley Colton, Joann Barker, Katie Birchall, Kate Harrington, Kay Housley, Rebecca Lenagh, Jayne Wilson, Joan Wesonga, Rachel Whitham, Sarah Bird, Yvonne Jackson, Angeline Mbuyisa, Samantha Anderson, Anna Wilson, Faith Kibutu, Sara Walker, Kay Cawthron, Irene Macharia, Lynne Smart, Anna Emery, Alice Howell, Elizabeth Hurditch, Amber Ford, Kim Turner, Lisa Watson, Helen Bowler, Tracy Jackson, Carol Jaques, Nichole Dyer, Shelley Ducker, Vicky Goodall, Emily Udale
This study was funded by an investigator-initiated research grant from Insmed (Bridgewater, NJ, USA). The authors acknowledge the funding and logistical support from the UK National Institute for Health and Care Research. Background: Neutrophil serin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832a45ad7d7f0d50d9a326a100f7d7b
https://eprints.whiterose.ac.uk/190854/1/1-s2.0-S2213260022002612-main.pdf
https://eprints.whiterose.ac.uk/190854/1/1-s2.0-S2213260022002612-main.pdf
Autor:
Cheryl L. Hume, Peter T. Donnan, Jacob George, Avan Aihie Sayer, Allan D. Struthers, Kristina Pilvinyte, Margaret M Band, Paul R. Kemp, Terry J. Aspray, Karen Smith, Marcus Achison, Alison Avenell, Deepa Sumukadas, Miles D. Witham, Adrian Hapca
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 93-102 (2021)
Background Sarcopenia is rarely diagnosed and is not recorded electronically in routine clinical care, posing challenges to trial recruitment. We describe the performance of four components of a strategy to efficiently recruit participants with sarco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dd9bafc2c54b9a66b0889679b3b145
http://hdl.handle.net/10044/1/88886
http://hdl.handle.net/10044/1/88886
Autor:
Jonathan Grigg, Roger Tavendale, Helen Smith, Somnath Mukhopadhyay, Roberta Littleford, Kristina Pilvinyte, Colin N. A. Palmer, Fiona Hogarth, Christina J Jones, Steve Turner, Thomas Ruffles, Brian J. Lipworth, Petra Rauchhaus
Publikováno v:
Paediatric asthma and allergy.
Introduction: The A allele of rs1042713 (Arg16 amino acid) is associated with poor response to long-acting β2 agonist (LABA) in young people with asthma. We aimed to evaluate whether prescribing asthma controller medication according to rs1042713 ge
Autor:
Thomas Ruffles, Steve Turner, Jonathan Grigg, Romanie Hannah, Somnath Mukhopadhyay, Roberta Littleford, Kristina Pilvinyte, Brian Lipworth, Helen Smith, Petra Rauchhaus, Fiona Hogarth, Christina J Jones, Roger Tavendale, Colin N. A. Palmer
Publikováno v:
European Respiratory Journal. 58:2004107
IntroductionThe A allele of rs1042713 (Arg16 amino acid) in the β2-adrenoreceptor is associated with poor response to long-acting β2-agonist (LABA) in young people with asthma. Our aim was to assess whether the prescribing of second-line controller