Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kristina M. Lemonidis"'
Autor:
Mark J. Graham, Kristina M. Lemonidis, Charles P. Whipple, Amuthakannan Subramaniam, Brett P. Monia, Stanley T. Crooke, Rosanne M. Crooke
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 763-767 (2007)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism. We developed second generation
Externí odkaz:
https://doaj.org/article/de73d8692cae40cd8902c9742360e4eb
Autor:
Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Charles P. Whipple, Seonjoon Koo, Ranjan J. Perera
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 5, Pp 872-884 (2005)
High levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL, are associated with cardiovascular disease. We hypothesized that suppression of apoB-100 mRNA by an antisense oligonucleotide (ASO) would reduce LDL cholester
Externí odkaz:
https://doaj.org/article/3fc1ab9091604ad3bc3e80c05d5397f2
Autor:
Rosanne M. Crooke, Mark J. Graham, Michael V. Templin, Kristina M. Lemonidis, Stanley T. Crooke, Hans Gaus
Publikováno v:
Biochemical Pharmacology. 62:297-306
The pharmacokinetics of ISIS 1082, a 21-base heterosequence phosphorothioate oligodeoxynucleotide, were characterized within rodent whole liver, and cellular and subcellular compartments. Cross-species comparisons were performed using Sprague-Dawley
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11bd536837fec62803a3c125cd782d0e
https://doi.org/10.1016/s0006-2952(01)00669-4
https://doi.org/10.1016/s0006-2952(01)00669-4
Autor:
Arthur A. Levin, Mark K. Wedel, John Matson, Kristina M. Lemonidis, Richard S. Geary, Mark J. Graham, Rosie Z. Yu, Diane Tribble, Rosanne M. Crooke
Publikováno v:
Biochemical pharmacology. 77(5)
The in vivo pharmacokinetics/pharmacodynamics of 2'-O-(2-methoxyethyl) (2'-MOE) modified antisense oligonucleotides (ASOs), targeting apolipoprotein B-100 (apoB-100), were characterized in multiple species. The species-specific apoB antisense inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f750b89df103a0a85deb76476ff000
https://pubmed.ncbi.nlm.nih.gov/19056355
https://pubmed.ncbi.nlm.nih.gov/19056355
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d8611c8517b5bba8575297cbbb5d5f
https://doi.org/10.1096/fasebj.21.5.a109-c
https://doi.org/10.1096/fasebj.21.5.a109-c
Autor:
Kristina M. Lemonidis, Brett P. Monia, Mark J. Graham, Rosanne M. Crooke, Charles P. Whipple, Stanley T. Crooke, Amuthakannan Subramaniam
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 763-767 (2007)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an as yet undefined mechanism. We developed second generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be5c75f671b6d55dbcc9c016e30e56c
https://pubmed.ncbi.nlm.nih.gov/17242417
https://pubmed.ncbi.nlm.nih.gov/17242417
Autor:
Kristina M. Lemonidis, Rosanne M. Crooke, J. Mark Brown, Mark J. Graham, Lawrence L. Rudel, Thomas A. Bell
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 26(8)
Objective— The purpose of this study was to determine the effects of liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) on the development of hypercholesterolemia and atherosclerosis in mice. Methods and Results— A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627da35d3e4996bf119f3ce4c14812e6
https://pubmed.ncbi.nlm.nih.gov/16857957
https://pubmed.ncbi.nlm.nih.gov/16857957
Autor:
Nicholas M. Dean, Kristina M. Lemonidis, Mark J. Graham, Chenguang Zhao, Timothy A. Vickers, Hong Zhang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 176(6)
A number of proinflammatory cytokines, including IL-1β, signal through the adaptor protein MyD88. This signaling leads to phosphorylation of IL-1R-associated kinase-1 (IRAK-1) and, ultimately, activation of the NF-κB transcription factor. A splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bd294c9c3fbbee1ac4fd168cd2520a
https://pubmed.ncbi.nlm.nih.gov/16517734
https://pubmed.ncbi.nlm.nih.gov/16517734
Autor:
Andrea R. Schievella, Vincent P. Stanton, Jeffrey Olson, Erica Burns, Patrice R. Rioux, Brett P. Monia, David E. Housman, Kristina M. Lemonidis, James P. Basilion
Publikováno v:
Molecular pharmacology. 56(2)
Most drugs for cancer therapy are targeted to relative differences in the biological characteristics of cancer cells and normal cells. The therapeutic index of such drugs is theoretically limited by the magnitude of such differences, and most antican
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e99684406d94d7b30c2d6dd5594add8
https://pubmed.ncbi.nlm.nih.gov/10419555
https://pubmed.ncbi.nlm.nih.gov/10419555
Autor:
Stanley T. Crooke, Brett P. Monia, Kristina M. Lemonidis, L Neilson, Elena A. Lesnik, Richard H. Griffey
1. The effects of variations in substrates on the kinetic properties of Escherichia coli RNase H were studied using antisense oligonucleotides of various types hybridized to complementary oligoribonucleotides. The enzyme displayed minimal sequence pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4c0116f1da7b157c91195d23ceed7c
https://europepmc.org/articles/PMC1136304/
https://europepmc.org/articles/PMC1136304/
