ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

Autor: Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Amit Kumar, Jiri Bartek, Zhao-Qi Wang, Marco Foiani

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and

Externí odkaz: https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d2

Data from 3D-Informed Targeting of the Trop-2 Signal-Activation Site Drives Selective Cancer Vulnerability

Autor: Saverio Alberti, Laura Antolini, Nicola Tinari, Manuela Iezzi, Pietro Roversi, Massimo Pedriali, Patrizia Querzoli, Nicole Travali, Pasquale Simeone, Kristina M. Havas, Andrea Sacchetti, Ludovica Pantalone, Khouloud Boujnah, Martina Ceci, Romina Tripaldi, Rossano Lattanzio, Valeria Relli, Marco Trerotola, Emanuela Guerra

Next-generation Trop-2–targeted therapy against advanced cancers is hampered by expression of Trop-2 in normal tissues. We discovered that Trop-2 undergoes proteolytic activation by ADAM10 in cancer cells, leading to the exposure of a previously in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643e3a47b8127482baa4b306ef223703
https://doi.org/10.1158/1535-7163.c.6653601

3D-Informed Targeting of the Trop-2 Signal-Activation Site Drives Selective Cancer Vulnerability

Autor: Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Romina Tripaldi, Martina Ceci, Khouloud Boujnah, Ludovica Pantalone, Andrea Sacchetti, Kristina M. Havas, Pasquale Simeone, Nicole Travali, Patrizia Querzoli, Massimo Pedriali, Pietro Roversi, Manuela Iezzi, Nicola Tinari, Laura Antolini, Saverio Alberti

Next-generation Trop-2–targeted therapy against advanced cancers is hampered by expression of Trop-2 in normal tissues. We discovered that Trop-2 undergoes proteolytic activation by ADAM10 in cancer cells, leading to the exposure of a previously in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4edc1bcbc4ea474f57a82e66a82adb
https://hdl.handle.net/10281/425958

Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells

Autor: Benjamin J Hershey, Roberta Vazzana, Débora L Joppi, Kristina M Havas

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 9, Iss 1, p 87 (2019)
Journal of Clinical Medicine; Volume 9; Issue 1; Pages: 87

Tumor recurrence is now the leading cause of breast cancer-related death. These recurrences are believed to arise from residual cancer stem cells that survive initial therapeutic intervention. Therefore, a comprehensive understanding of cancer stem c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabf7c9944804529d187fd58607ecca2
http://europepmc.org/articles/PMC7019257

Novel ATPase of SNF2-like Protein Family Interacts with Androgen Receptor and Modulates Androgen-dependent Transcription

Autor: Nathalie Rouleau, Tom Owen-Hughes, Anu-Maarit Moilanen, Zhigang Kang, Olli A. Jänne, Kristina M. Havas, Jorma J. Palvimo, Mati Reeben, Andrii Domanskyi

Publikováno v: Molecular Biology of the Cell. 13:2106-2119

Nuclear receptors, including the androgen receptor (AR), regulate target cell transcription through interaction with auxiliary proteins to modify chromatin structure. We describe herein a novel AR-interacting protein, termed ARIP4, that has structura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd34505f5d5481c8b8b6d862cf5c979
https://doi.org/10.1091/mbc.01-10-0484