Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kristina M, Ilieva"'
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Autor:
Robert W Wilkinson, Hormas Ghadially, Stacy Kentner, Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Matthew J Robinson, Tim Slidel, Simon J Dovedi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Immuno-oncology therapies are now part of the standard of care for cancer in many indications. However, durable objective responses remain limited to a subset of patients. As such, there is a critical need to identify biomarkers that can p
Externí odkaz:
https://doaj.org/article/0daba65ab2174eb2906d5b3b2486abf0
Autor:
Iwan P. Williams, Silvia Crescioli, Heng Sheng Sow, Heather J. Bax, Carl Hobbs, Kristina M. Ilieva, Elise French, Giulia Pellizzari, Vivienne Cox, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis, Silvia Mele
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
IgE monoclonal antibodies hold great potential for cancer therapy. Preclinical in vivo systems, particularly those in which the antibody recognizes the host species target antigen and binds to cognate Fc receptors, are often the closest approximation
Externí odkaz:
https://doaj.org/article/6ff446d9996240a9913b11d5fd13c531
Autor:
Laura Montero-Morales, Daniel Maresch, Silvia Crescioli, Alexandra Castilho, Kristina M. Ilieva, Silvia Mele, Sophia N. Karagiannis, Friedrich Altmann, Herta Steinkellner
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Human immunoglobulin E (IgE) is the most extensively glycosylated antibody isotype so glycans attached to the seven N-glycosites (NGS) in its Fab and Fc domains may modulate its functions. However, targeted modification of glycans in multiply glycosy
Externí odkaz:
https://doaj.org/article/5e2116d1d21c44209f0d73d72e844827
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Evaluation of FRalpha expression by tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38db7cb9edccc92a72b16204c6c84d78
https://doi.org/10.1158/0008-5472.22416014.v1
https://doi.org/10.1158/0008-5472.22416014.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Table of Patient Characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae24e70842a424500fbe06f48794886
https://doi.org/10.1158/0008-5472.22416008.v1
https://doi.org/10.1158/0008-5472.22416008.v1
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816bd38045ed7ffde480f7e6dc0d11ea
https://doi.org/10.1158/0008-5472.c.6509447.v1
https://doi.org/10.1158/0008-5472.c.6509447.v1
Autor:
Sophia N. Karagiannis, Andrew N.J. Tutt, Anita Grigoriadis, James F. Spicer, Cheryl Gillett, Frank O. Nestle, Sarah Pinder, Mariangela Figini, Silvana Canevari, Debra H. Josephs, Daniel Larcombe-Young, Gyula Petranyi, Silvia Crescioli, Heather J. Bax, Giulia Pellizzari, Silvia Mele, Nirmesh Patel, Luned Badder, Angela Clifford, Diana Dominguez Rodriguez, Matthew Fittall, Erika Francesch-Domenech, Rebecca Marlow, Hasan Mirza, Ricarda M. Hoffmann, Patrycja Gazinska, Kristina M. Ilieva, James Opzoomer, Anthony Cheung
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeced1d042d1dc7c01723a2468cd543
https://doi.org/10.1158/1078-0432.c.6529226
https://doi.org/10.1158/1078-0432.c.6529226
Autor:
Sophia N. Karagiannis, James F. Spicer, Philip J. Blower, Victoria Sanz-Moreno, Hannah J. Gould, Paul S. Jones, Frank O. Nestle, Andrew J. Beavil, Christopher J. Corrigan, David Dombrowicz, Noel Downes, Ana Montes, Mariangela Figini, Silvana Canevari, Sophia Tsoka, Gareth Muirhead, Elliott Lever, Claire Barton, Heike Lentfer, Christopher Selkirk, Marguerite Bracher, Alexander Koers, Amy E. Gilbert, Giulia Chiaruttini, Silvia Mele, Natalie Woodman, Patrycja Gazinska, Silvia Crescioli, Matthew Fittall, Isabel Correa, Kristina M. Ilieva, Cecilia Herraiz, Anthony Cheung, Panagiotis Karagiannis, Louise Saul, Giulia Pellizzari, Mano Nakamura, Mirella Georgouli, Tihomir Dodev, Heather J. Bax, Debra H. Josephs
Description of additional experiments and procedures carried out in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e224e5f523a06cb1b657edf1f2f3944
https://doi.org/10.1158/0008-5472.22416011.v1
https://doi.org/10.1158/0008-5472.22416011.v1