New approach methods for assessing indoor air toxicity

Autor: Marika Mannerström, Marketa Dvorakova, Lada Svobodova, Marian Rucki, Filip Kotal, Adam Vavrouš, Věra Vrbíková, Kristina Kejlova, Dagmar Jirova, Tuula Heinonen

Publikováno v: Current Research in Toxicology, Vol 3, Iss , Pp 100090- (2022)

Indoor air is typically a mixture of many chemicals at low concentrations without any adverse health effects alone, but in mixtures they may cause toxicity and risks to human health. The aim of this study was by using new approach methods to assess t

Externí odkaz: https://doaj.org/article/fe6da1ed006c4ba288c88cd47d3e12e5

Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating

Autor: Marek Novák, Jozef Rosina, Hana Bendová, Kristina Kejlová, Alena Vlková, Marian Rucki, Lada Svobodová, Robert Gürlich, Jan Hajer

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract The research of novel implantable medical devices is one of the most attractive, yet complex areas in the biomedical field. The design and development of sufficiently small devices working in an in vivo environment is challenging but success

Externí odkaz: https://doaj.org/article/3738505632a642a8ba821bf79dcb71d5

The Current Status and Work of Three Rs Centres and Platforms in Europe*

Autor: Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Eliška Kuchovská, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, Edyta Reszka, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Emma Svensk, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Jens Kurreck, Horst Spielmann

Publikováno v: Alternatives to Laboratory Animals. 50:381-413

The adoption of Directive 2010/63/EU on the protection of animals used for scientific purposes has given a major push to the formation of Three Rs initiatives in the form of centres and platforms. These centres and platforms are dedicated to the so-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc36c6df121407af00ec21546f6f685f
https://doi.org/10.1177/02611929221140909

Evaluation of toxicity profiles of rare earth elements salts (lanthanides)

Autor: Marian Rucki, Alena Vlková, Kristina Kejlová, L. Svobodova, Tuula Heinonen, Hana Kolarova, Silvia Letasiova, Dagmar Jírová, Marika Mannerström, Helena Kandarova, Marketa Dvorakova

Publikováno v: Journal of Rare Earths. 39:225-232

The presented study aims to extend the knowledge of toxicological profile of rare earth elements salts (REEs). The basal toxicity test performed comprised assessment of cytotoxicity (3T3 Balb/c Neutral Red Uptake Test) that allows for calculation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1361958472bc876faa76bf8aa5f05ac
https://doi.org/10.1016/j.jre.2020.02.011

The Rise of Three Rs Centres and Platforms in Europe

Autor: Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar Jírová, Kristina Kejlová, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, Vivian Kral, Christa Thöne-Reineke, Thomas Hartung, Giorgia Pallocca, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, Stephanie Krämer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Manuela Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kränzlin, Bettina Seeger, Maren von Köckritz-Blickwede, José M. Sánchez-Morgado, Viola Galligioni, Daniel Ruiz-Pérez, Dania Movia, Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Stępnik, Zuzanna Sobańska, I. Anna S. Olsson, Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Christopher R. Cederroth, Jenny Sandström, Ian Ragan, Nataliia Bubalo, Horst Spielmann

Publikováno v: ATLA-ALTERNATIVES TO LABORATORY ANIMALS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Public awareness and discussion about animal experiments and replacement methods has greatly increased in recent years. The term ‘the Three Rs’, which stands for the Replacement, Reduction and Refinement of animal experiments, is inseparably link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01736f127bcfc51bf6af214ad3a3d859
https://pubmed.ncbi.nlm.nih.gov/35578444