Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kristina K, Wolf"'
Autor:
Jessica R. Weaver, Justin J. Odanga, Kristina K. Wolf, Stephanie Piekos, Mercedes Biven, Mitchell Taub, Jessica LaRocca, Cody Thomas, Alexander Byer-Alcorace, Jingsong Chen, Jung Bok Lee, Edward L. LeCluyse
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 86
There remains a significant need for a convenient, phenotypically stable long-term culture platform for primary human hepatocytes (PHHs) for use in pharmacological and toxicological applications. Conventional in vitro models are often inconvenient, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afa037f981b014ced9922835e80f3e7
https://pubmed.ncbi.nlm.nih.gov/36288780
https://pubmed.ncbi.nlm.nih.gov/36288780
Autor:
John K Thuita, Kristina K Wolf, Grace A Murilla, Arlene S Bridges, David W Boykin, James N Mutuku, Qiang Liu, Susan K Jones, Charles O Gem, Shelley Ching, Richard R Tidwell, Michael Z Wang, Mary F Paine, Reto Brun
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003409 (2015)
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infe
Externí odkaz:
https://doaj.org/article/aad4fdcad9934c25a153ed2b89ab73e9
Autor:
Kristina K. Wolf, Merrie Mosedale, Manisha Nautiyal, Paul B. Watkins, Edward L. LeCluyse, Kelly A Rose, Rachel J. Church, Natalie S. Holman, Sarah E Thacker, Monicah A. Otieno
Publikováno v:
Toxicol Sci
Most idiosyncratic drug-induced liver injury appears to result from an adaptive immune attack on the liver. Recent evidence suggests that the T-cell response may be facilitated by the loss of immune tolerance. In this study, we explored the hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473bbe51ee3fae1d85bf5de7f26392ac
https://doi.org/10.1093/toxsci/kfz112
https://doi.org/10.1093/toxsci/kfz112
Autor:
John K Thuita, Kristina K Wolf, Grace A Murilla, Qiang Liu, James N Mutuku, Yao Chen, Arlene S Bridges, Raymond E Mdachi, Mohamed A Ismail, Shelley Ching, David W Boykin, James Edwin Hall, Richard R Tidwell, Mary F Paine, Reto Brun, Michael Zhuo Wang
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2230 (2013)
There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs of HAT. The development of
Externí odkaz:
https://doaj.org/article/3329b3b038db4c1fbbbafc2be436adde
Autor:
Rani J. Qasem, Jingli Liu, Darlene Dixon, John K. Fallon, Merrie Mosedale, Philip C. Smith, Kristina K. Wolf, Manisha Nautiyal
Publikováno v:
Toxicol In Vitro
Primary mouse hepatocytes isolated from genetically defined and/or diverse lines and disease models are a valuable resource for studying the impact of genetic and environmental factors on drug response and disease. However, standard monolayer culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b927b7b0da48989f2b3cd16d927da8fb
https://doi.org/10.1016/j.tiv.2020.105010
https://doi.org/10.1016/j.tiv.2020.105010
The human gastrointestinal (GI) tract is exposed constantly to a variety of xenobiotics, including those derived from the air, diet, and bile, as well as pharmacological agents. The body’s ability to remain healthy, despite constant exposure to xen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30cd24e7d2bd79e7b8b25328f0d64eae
https://doi.org/10.1016/b978-0-12-801238-3.95671-x
https://doi.org/10.1016/b978-0-12-801238-3.95671-x
Autor:
Natalie S. Holman, Jingtao Lu, Brenton R. Ware, O. Joseph Trask, Salman R. Khetani, Merrie Mosedale, Edward L. LeCluyse, Sharin E. Roth, William J. Brock, Paul B. Watkins, Kristina K. Wolf, J. Scott Eaddy
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 161(1)
Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune attack on the liver. However, it has been proposed that the cascade of events culminating in an adaptive immune response begins with drug-induced hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2647cc23593229dfcd1d3882738a49
https://pubmed.ncbi.nlm.nih.gov/29029277
https://pubmed.ncbi.nlm.nih.gov/29029277
Autor:
Mary F. Paine, Yolanda Scarlett, Garrett R. Ainslie, J. Heyward Hull, Elizabeth A. Connolly, Yingxin Li, Kristina K. Wolf
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:576-584
Dietary substances, including herbal products and citrus juices, can perpetrate interactions with conventional medications. Regulatory guidances for dietary substance-drug interaction assessment are lacking. This deficiency is due in part to challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3834f822875ed3de5b9248b5bad5314b
https://doi.org/10.1124/jpet.114.216838
https://doi.org/10.1124/jpet.114.216838
Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence suggests that signaling molecules released by stressed hepatocytes c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cfc0cfd9d93da3e4e80de0f33292ca
Autor:
Kim L. R. Brouwer, Joseph W. Polli, Grant T. Generaux, Sapana Vora, Kristina K. Wolf, Lindsey O. Webster
Publikováno v:
Toxicology in Vitro. 24:297-309
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some hepatotoxic compounds also are potent inhibitors of bile acid uptak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71950041397695c888168ae77c63478f
https://doi.org/10.1016/j.tiv.2009.08.009
https://doi.org/10.1016/j.tiv.2009.08.009