An Influence of Modification with Phosphoryl Guanidine Combined with a 2′-O-Methyl or 2′-Fluoro Group on the Small-Interfering-RNA Effect

Autor: Elena I. Ryabchikova, Anna S. Pavlova, Kristina I. Yakovleva, Inna A. Pyshnaya, Anna V. Epanchitseva, Dmitrii V. Pyshnyi, Ilya S. Dovydenko, Maxim S. Kupryushkin

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9784, p 9784 (2021)
Volume 22
Issue 18

Small interfering RNA (siRNA) is the most important tool for the manipulation of mRNA expression and needs protection from intracellular nucleases when delivered into the cell. In this work, we examined the effects of siRNA modification with the phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d2b88992daccaa9a5bf68879a442d3
http://europepmc.org/articles/PMC8467447