Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristina Hupperich"'
Autor:
Eva Janzen, Lisa Wolff, Natalia Mendoza-Ferreira, Kristina Hupperich, Andrea Delle Vedove, Seyyedmohsen Hosseinibarkooie, Min Jeong Kye, Brunhilde Wirth
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Many neurodegenerative disorders share common pathogenic pathways such as endocytic defects, Ca2+ misregulation and defects in actin dynamics. Factors acting on these shared pathways are highly interesting as a therapeutic target. Plastin 3 (PLS3), a
Externí odkaz:
https://doaj.org/article/65c3660dc28c4f03babf89ef4c4949db
Autor:
Markus Storbeck, Kristina Hupperich, John Antonydas Gaspar, Kesavan Meganathan, Lilian Martínez Carrera, Radu Wirth, Agapios Sachinidis, Brunhilde Wirth
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89020 (2014)
Alternative splicing (AS) increases the informational content of the genome and is more prevalent in the brain than in any other tissue. The splicing factor Tra2b (Sfrs10) can modulate splicing inclusion of exons by specifically detecting GAA-rich bi
Externí odkaz:
https://doaj.org/article/c7902662dbc7407d9bcccd95bb59be23
Autor:
Seyyedmohsen Hosseinibarkooie, Frank Zaucke, Brunhilde Wirth, Theresa Tschanz, Anja Niehoff, Miriam Peters, Vanessa Grysko, Irmgard Hölker, Janine Neugebauer, Natalia Mendoza-Ferreira, Franziska Nolte, Juliane Heilig, Kristina Hupperich, Bryony C Ross
Publikováno v:
Human molecular genetics. 27(24)
Over 200 million people suffer from osteoporosis worldwide, one third of which will develop osteoporotic bone fractures. Unfortunately, no effective cure exists. Mutations in plastin 3 (PLS3), an F-actin binding and bundling protein, cause X-linked p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e776a06525b0373c13eb588d8e94cd71
https://pubmed.ncbi.nlm.nih.gov/30204862
https://pubmed.ncbi.nlm.nih.gov/30204862
Autor:
Seyyedmohsen Hosseinibarkooie, Markus Riessland, Laura Torres-Benito, Natalia Mendoza-Ferreira, Eva Janzen, Svenja Schneider, Frank Rigo, Kristina Hupperich, Min Jeong Kye, Vanessa Grysko, Matthias Hammerschmidt, Brunhilde Wirth, Theresa Tschanz, C. Frank Bennett
Publikováno v:
Brain
Plastin3 is a protective modifier of spinal muscular atrophy (SMA). Janzen et al. report that CHP1 interacts directly with plastin3, and that CHP1 suppression reduces SMA pathology in cellular and animal models by restoring impaired endocytosis. CHP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1728b8f988d42bd4b09fbaee70a6664
https://pubmed.ncbi.nlm.nih.gov/29961886
https://pubmed.ncbi.nlm.nih.gov/29961886
Autor:
C. Frank Bennett, Andrea Hoffmann, Anna Kaczmarek, Markus Riessland, Seyyedmohsen Hosseinibarkooie, Miriam Peters, Ansgar Büschges, Min Jeong Kye, Frank Rigo, Christoph Guschlbauer, Eva Janzen, Tobias Lamkemeyer, Laura Torres-Benito, Raphael H. Rastetter, Natalia Mendoza-Ferreira, Christoph S. Clemen, Matthias Hammerschmidt, Kristina Hupperich, Brunhilde Wirth, Janine Milbradt
Homozygous loss of SMN1 causes spinal muscular atrophy (SMA), the most common and devastating childhood genetic motor-neuron disease. The copy gene SMN2 produces only ∼10% functional SMN protein, insufficient to counteract development of SMA. In co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e300456b6e182518780584026a3bdbdf
https://europepmc.org/articles/PMC5011078/
https://europepmc.org/articles/PMC5011078/
Autor:
Swetlana Ritzenhofen, Michael Peitz, Brunhilde Wirth, Laura Torres-Benito, Daniela Eckert, Irmgard Hölker, Min Jeong Kye, Seyyedmohsen Hosseinibarkooie, Raoul Heller, Johannes Jungverdorben, Oliver Brüstle, Markus Storbeck, Renata Lonigro, Beatrice Weykopf, Kristina Dobrindt, Noemi Fusaki, Kristina Hupperich, Ludwig Heesen
Publikováno v:
Cellular and molecular life sciences 73(10), 2089-2104 (2015). doi:10.1007/s00018-015-2084-y
Spinal muscular atrophy (SMA) is a devastating motoneuron (MN) disorder caused by homozygous loss of SMN1. Rarely, SMN1-deleted individuals are fully asymptomatic despite carrying identical SMN2 copies as their SMA III-affected siblings suggesting pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697b72ca08719ad06a12beea62d9e6fc
https://pub.dzne.de/record/138510
https://pub.dzne.de/record/138510
Autor:
Kesavan Meganathan, Agapios Sachinidis, Kristina Hupperich, Lilian A. Martínez Carrera, John Antonydas Gaspar, Brunhilde Wirth, Markus Storbeck, Radu Wirth
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89020 (2014)
PLoS ONE; Vol 9
PLoS ONE, Vol 9, Iss 2, p e89020 (2014)
PLoS ONE; Vol 9
Alternative splicing (AS) increases the informational content of the genome and is more prevalent in the brain than in any other tissue. The splicing factor Tra2b (Sfrs10) can modulate splicing inclusion of exons by specifically detecting GAA-rich bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5746c46bb0297238b112940745eba4f
http://europepmc.org/articles/PMC3929626
http://europepmc.org/articles/PMC3929626