Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kristina Hakenova"'
Autor:
Marketa Chvojkova, David Kolar, Katarina Kovacova, Lada Cejkova, Anna Misiachna, Kristina Hakenova, Lukas Gorecki, Martin Horak, Jan Korabecny, Ondrej Soukup, Karel Vales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116821- (2024)
Therapeutic options for Alzheimer’s disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and simultaneously N-methyl-D-as
Externí odkaz:
https://doaj.org/article/ba09458e987a4172bb5b911d5bb2a16e
Autor:
Rafael Dolezal, Kristina Hakenova, Jiri Damborsky, Marharyta Kolcheva, Karel Vales, Jan Korabecny, Lada Cejkova, Marketa Chvojkova, Anna Misiachna, Martin Novák, Ondrej Soukup, Lukas Prchal, Lukas Gorecki, Jana Zdarova Karasova, Martin Horak, Stepan Kortus
Publikováno v:
European journal of medicinal chemistry. 219
Tacrine is a classic drug whose efficacy against neurodegenerative diseases is still shrouded in mystery. It seems that besides its inhibitory effect on cholinesterases, the clinical benefit is co-determined by NMDAR-antagonizing activity. Our previo
Autor:
Kristina Hakenova, Katarina Lichnerova, Martin Horak, Barbora Krausova, Vendula Hepnarova, Karel Vales, Jan Korabecny, Barbora Svobodova, Tomas Kucera, Lukas Prchal, Lenka Kleteckova, Ondrej Soukup, Kristina Holubova, Martin Novák, Rafael Dolezal, Martina Kaniakova, Marketa Chvojkova
Publikováno v:
Biochemical pharmacology. 186
N-methyl-D-aspartaterecepro receptor (NMDARs) are a subclass of glutamate receptors, which play an essential role in excitatory neurotransmission, but their excessive overactivation by glutamate leads to excitotoxicity. NMDARs are hence a valid pharm