Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kristina Haeussler"'
Autor:
Kristina Haeussler, Isabell Berneburg, Esther Jortzik, Julia Hahn, Mahsa Rahbari, Norma Schulz, Janina Preuss, Viktor A. Zapol’skii, Lars Bode, Anthony B. Pinkerton, Dieter E. Kaufmann, Stefan Rahlfs, Katja Becker
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-19 (2019)
Abstract Background Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In P
Externí odkaz:
https://doaj.org/article/cfe88e3100ec47a894b92d5d4f9bad02
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7532 (2020)
Colorectal cancer (CRC) is one of the most frequently diagnosed tumor in humans and one of the most common causes of cancer-related death worldwide. The pathogenesis of CRC follows a multistage process which together with somatic gene mutations is ma
Externí odkaz:
https://doaj.org/article/b042a12c97964e4eb47f10afedd427d3
Publikováno v:
Cells, Vol 8, Iss 8, p 797 (2019)
An increased expression and cytoplasmic abundance of the ubiquitous RNA binding protein human antigen R (HuR) is critically implicated in the dysregulated control of post-transcriptional gene expression during colorectal cancer development and is fre
Externí odkaz:
https://doaj.org/article/07bca7c8cc894a588825006421f538de
Autor:
Isabell Berneburg, Satyamaheshwar Peddibhotla, Kim C. Heimsch, Kristina Haeussler, Patrick Maloney, Palak Gosalia, Janina Preuss, Mahsa Rahbari, Oleksii Skorokhod, Elena Valente, Daniela Ulliers, Luigi Felice Simula, Kathrin Buchholz, Michael P. Hedrick, Paul Hershberger, Thomas D. Y. Chung, Michael R. Jackson, Evelin Schwarzer, Stefan Rahlfs, Lars Bode, Katja Becker, Anthony B. Pinkerton
Publikováno v:
Antimicrob Agents Chemother
In Plasmodium, the first two and rate-limiting enzymes of the pentose phosphate pathway, glucose 6-phosphate dehydrogenase (G6PD) and the 6-phosphogluconolactonase, are bifunctionally fused to a unique enzyme named GluPho, differing structurally and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b78be63f8ec7830ea15109c7201d38
https://hdl.handle.net/2318/1871678
https://hdl.handle.net/2318/1871678
Autor:
Dieter E. Kaufmann, Katja Becker, Viktor A. Zapol'skii, Anthony B. Pinkerton, Julia Hahn, Isabell Berneburg, Mahsa Rahbari, Janina Preuss, Lars Bode, Stefan Rahlfs, Esther Jortzik, Kristina Haeussler, Norma Schulz
Publikováno v:
Malaria Journal
Malaria Journal, Vol 18, Iss 1, Pp 1-19 (2019)
Malaria Journal, Vol 18, Iss 1, Pp 1-19 (2019)
Background Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In Plasmodium
Publikováno v:
Journal of Molecular Biology (London)
The enzyme 6-phosphogluconate dehydrogenase (6PGD) of the malaria parasite Plasmodium falciparum catalyzes the third step of the pentose phosphate pathway converting 6-phosphogluconate (6PG) to ribulose 5-phosphate. The NADPH produced by 6PGD is cruc
Autor:
Matthew T. Downton, Malcolm J. McConville, James I. MacRae, Katja Becker, Erin E. Lim, Kristina Haeussler, Stuart A. Ralph, Esther Jortzik, Janina Preuss, Hwa Huat Chua, Stefan Rahlfs, Stacey M. Allen
Publikováno v:
FEBS Journal. 282:3808-3823
The malarial parasite Plasmodium falciparum is exposed to substantial redox challenges during its complex life cycle. In intraerythrocytic parasites, haemoglobin breakdown is a major source of reactive oxygen species. Deficiencies in human glucose-6-