Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kristina Grauer"'
Autor:
Jay Moon, Franklyn Ngundam, Erin Milner, Erin Harris, Sandi Parriott, Richard J. Sciotti, Brittney Potter, Qigui Li, Patricia J. Lee, Michael T. O’Neil, Michael P. Kozar, Sean Gardner, Diana Caridha, Jennifer M. Auschwitz, Anchalee Tangteung, Kristina Grauer, Mark Hickman, Geoffrey S. Dow, Susan E. Leed, Jason C. Sousa, Brandon S. Pybus, Victor Melendez
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 37:17-22
Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models. However, the low plasma levels and short half life of the drug do not adequately explain its in vivo efficacy. We synthesized most of the known metabolites of ket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff844de657e2fb34fa0cd6b909b0398
https://doi.org/10.1007/s13318-012-0080-2
https://doi.org/10.1007/s13318-012-0080-2
Autor:
Lucia Gerena, Richard J. Sciotti, Qigui Li, Bryan Smith, Erin Milner, Victor Melendez, Norma Roncal, Ian Bathurst, Jennifer M. Auschwitz, Jason C. Sousa, Geoffrey S. Dow, Susan E. Leed, Michael P. Kozar, Jacob D. Johnson, William McCalmont, Sean Gardner, Anchalee Tungtaeng, Jay Moon, Peter Wipf, Montip Gettayacamin, Patricia J. Lee, Diana Caridha, Kristina Grauer
Publikováno v:
Journal of medicinal chemistry. 54(18)
A library of diamine quinoline methanols were designed based on the mefloquine scaffold. The systematic variation of the 4-position amino alcohol side chain led to analogues that maintained potency while reducing accumulation in the central nervous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b74ea79cbda2595143e6bda57a4d0a1
https://pubmed.ncbi.nlm.nih.gov/21854078
https://pubmed.ncbi.nlm.nih.gov/21854078
Autor:
Jason C. Sousa, William McCalmont, Qiang Zeng, Erin Milner, Dustin Carroll, Jennifer M. Auschwitz, Patricia J. Lee, Michael P. Kozar, Sean Gardner, Jay Moon, Brandon S. Pybus, Anchalee Tungtaeng, Kevin D. Read, Qigui Li, Victor Melendez, Montip Gettayacamin, Kristina Grauer, Suzanne Norval, Geoffrey S. Dow, Susan E. Leed
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 36(3)
WR319691 has been shown to exhibit reasonable Plasmodium falciparum potency in vitro and exhibits reduced permeability across MDCK cell monolayers, which as part of our screening cascade led to further in vivo analysis. Single-dose pharmacokinetics w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f50feabf923bd8c6c22d2b6e3148b31
https://pubmed.ncbi.nlm.nih.gov/21751074
https://pubmed.ncbi.nlm.nih.gov/21751074