Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kristina G. Maxwell"'
Autor:
Marlie M. Maestas, Matthew Ishahak, Punn Augsornworawat, Daniel A. Veronese-Paniagua, Kristina G. Maxwell, Leonardo Velazco-Cruz, Erica Marquez, Jiameng Sun, Mira Shunkarova, Sarah E. Gale, Fumihiko Urano, Jeffrey R. Millman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing from human samples and studies using in vitro and in vivo models suggest that endoplasmic reticulum and inflammatory signaling play an important r
Externí odkaz:
https://doaj.org/article/384db0eca8114c448f1019714f611871
Autor:
Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark J. Henderson, Jeffrey R. Millman, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram
Externí odkaz:
https://doaj.org/article/24a5fd515d1d461683a1b821a7ee0008
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100238- (2021)
Summary: Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These advances are enabling in vitro disease modeling studies
Externí odkaz:
https://doaj.org/article/b241cef2e79f47fdbed90a2ed9d304dd
Autor:
Leonardo Velazco-Cruz, Jiwon Song, Kristina G. Maxwell, Madeleine M. Goedegebuure, Punn Augsornworawat, Nathaniel J. Hogrebe, Jeffrey R. Millman
Publikováno v:
Stem Cell Reports, Vol 12, Iss 2, Pp 351-365 (2019)
Summary: Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have generated insulin-producing cells resembling pancreatic β cells. While these stem cell-derived β (SC-β) cells are capable of undergoing glucose-stimulate
Externí odkaz:
https://doaj.org/article/e0b99cbc138d49ee89ca9341cbfe50d4
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108850- (2021)
Externí odkaz:
https://doaj.org/article/81c86e686f9d4ebfbab552bc82af5ad5
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108067- (2020)
Summary: Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet organoids could provide an unlimited cell source for diabetes cell replacement therapy. However, current SC-β cells generated in vitro are tran
Externí odkaz:
https://doaj.org/article/53f7bf141973425f9f8e9f84420f1906
Autor:
Leonardo Velazco-Cruz, Madeleine M. Goedegebuure, Kristina G. Maxwell, Punn Augsornworawat, Nathaniel J. Hogrebe, Jeffrey R. Millman
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature
Externí odkaz:
https://doaj.org/article/7a25372c70bc4406a4a89c2dd99e4bef
Publikováno v:
Stem Cells Translational Medicine. 11:322-331
Insulin-producing stem cell-derived islets (SC-islets) provide a virtually unlimited cell source for diabetes cell replacement therapy. While SC-islets are less functional when first differentiated in vitro compared to isolated cadaveric islets, tran
Publikováno v:
Nat Protoc
We detail a 6-stage planar differentiation methodology for generating human pluripotent stem cell (hPSC)-derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in response to glucose stimulation. This protocol first induces de
Autor:
James A. Flanders, Kai Wang, Jing Chen, Minglin Ma, Kristina G. Maxwell, Alexander U. Ernst, Yong Wang, Chengyang Liu, Ali Naji, Xi Wang, Jeffrey R. Millman, Qingsheng Liu, Bo Wang, Juan M. Melero-Martin, Daniel T. Bowers, Wanjun Liu, Long-Hai Wang
Publikováno v:
Sci Transl Med
Transplantation of stem cell derived β (SC-β) cells represents a promising new therapy for type 1 diabetes (T1D). However, the delivery of these cells, ideally without immunosuppression and in a retrievable device that is both functional and safe,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5e952f3a757b04a90054fdbd9c1b6c
https://europepmc.org/articles/PMC8563008/
https://europepmc.org/articles/PMC8563008/