Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kristina Ehring"'
Autor:
Kristina Ehring, Sophia Friederike Ehlers, Jurij Froese, Fabian Gude, Janna Puschmann, Kay Grobe
Publikováno v:
eLife, Vol 12 (2024)
The Sonic hedgehog (Shh) signaling pathway controls embryonic development and tissue homeostasis after birth. This requires regulated solubilization of dual-lipidated, firmly plasma membrane-associated Shh precursors from producing cells. Although it
Externí odkaz:
https://doaj.org/article/ed76f5dfc952419ebf5d6291f2f6e66e
A Residual N-Terminal Peptide Enhances Signaling of Depalmitoylated Hedgehog to the Patched Receptor
Autor:
Sophia F. Ehlers, Dominique Manikowski, Georg Steffes, Kristina Ehring, Fabian Gude, Kay Grobe
Publikováno v:
Journal of Developmental Biology, Vol 12, Iss 2, p 11 (2024)
During their biosynthesis, Sonic hedgehog (Shh) morphogens are covalently modified by cholesterol at the C-terminus and palmitate at the N-terminus. Although both lipids initially anchor Shh to the plasma membrane of producing cells, it later translo
Externí odkaz:
https://doaj.org/article/187aca1451a64b67b6f17cfb26846c26
Autor:
Dominique Manikowski, Georg Steffes, Jurij Froese, Sebastian Exner, Kristina Ehring, Fabian Gude, Daniele Di Iorio, Seraphine V. Wegner, Kay Grobe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth
Externí odkaz:
https://doaj.org/article/448be748097d4105af3606a9394999ef
Autor:
Dominique Manikowski, Philipp Kastl, Sabine Schürmann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylat
Externí odkaz:
https://doaj.org/article/1948601f900e4a108549ae9bc7bf2a90
Autor:
Kristina Ehring, Kay Grobe
Publikováno v:
Biochemical Society Transactions
Vertebrate and invertebrate Hedgehog (Hh) morphogens signal over short and long distances to direct cell fate decisions during development and to maintain tissue homeostasis after birth. One of the most important questions in Hh biology is how such H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd428c144e745aa3cc90a3d0755fda20
https://doi.org/10.1042/bst20210918
https://doi.org/10.1042/bst20210918
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 43(11)
Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens-an N-terminal palmitate and a C-terminal cholesterol-are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a1634f28abd7df70d2a81f63a0e2e4
https://pubmed.ncbi.nlm.nih.gov/34611914
https://pubmed.ncbi.nlm.nih.gov/34611914
Autor:
Petra Jakobs, Uwe Kirchhefer, Dominique Manikowski, Kay Grobe, Jurij Froese, Kristina Ehring, Jonas Goretzko, Fabian Gude, Ursula Rescher
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The Sonic hedgehog (Shh) pathway controls embryonic development and tissue homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, firmly plasma membrane-associated Shh ligand is released from producing cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf64a2e57e8b30fb72c7ca65e494dd8
https://doi.org/10.1242/jcs.258672
https://doi.org/10.1242/jcs.258672
Autor:
Kristina Ehring, Georg Steffes, Kay Grobe, Sabine Schürmann, Dominique Manikowski, Philipp Kastl, Petra Jakobs
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf868e0d1d1c0dc3609fe4a71e6ea8d
https://doi.org/10.3389/fcell.2020.615698
https://doi.org/10.3389/fcell.2020.615698
Autor:
Ursula Rescher, Kristina Ehring, Fabian Gude, Dominique Manikowski, Kay Grobe, Jurij Froese, Petra Jakobs, Jonas Goretzko
SummaryThe Sonic hedgehog (Shh) pathway controls embryonic development and tissue homeostasis after birth. Long-lasting questions about this pathway are how dual-lipidated, firmly plasma membrane-associated Shh ligand is released from producing cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9a4aec840183c4b51315d2fc199520f
https://doi.org/10.1101/2020.10.19.346395
https://doi.org/10.1101/2020.10.19.346395
