Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kristina E. Halcomb"'
Autor:
Kristina E. Halcomb, Toni Gutierrez, Sandirai Musuka, Anne B. Satterthwaite, Heather L. Wright
Publikováno v:
Molecular Immunology. 46:233-241
The autoimmune disease systemic lupus erythematosus (SLE) is characterized by loss of tolerance to nuclear antigens such as chromatin, DNA, and RNA. This focused autoreactivity is thought to arise from the ability of DNA or RNA specific B cells to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd510c95eaf463ba34e46d2786821711
https://doi.org/10.1016/j.molimm.2008.08.278
https://doi.org/10.1016/j.molimm.2008.08.278
Autor:
Shoko Iwaki, Dean D. Metcalfe, Michael A. Beaven, Christine Tkaczyk, Kristina E. Halcomb, Alasdair M. Gilfillan, Anne B. Satterthwaite
Publikováno v:
Journal of Biological Chemistry. 280:40261-40270
Stem cell factor (SCF) acts in synergy with antigen to enhance the calcium signal, degranulation, activation of transcription factors, and cytokine production in human mast cells. However, the underlying mechanisms for this synergy remain unclear. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389055c8e99025c7e31345b559b31027
https://doi.org/10.1074/jbc.m506063200
https://doi.org/10.1074/jbc.m506063200
Publikováno v:
Journal of Mammalogy. 85:1160-1169
DNA sequences from the mitochondrial cytochrome-b gene were used to examine the composition and phylogenetic relationships of the Peromyscus truei species group. Thirty-one individuals from the southwestern United States and Mexico were examined. Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb6d9dc46c5004cd464ab92a7bd6316
https://doi.org/10.1644/ber-115.1
https://doi.org/10.1644/ber-115.1
Autor:
Kristina E. Halcomb, Anne B. Satterthwaite, Cristina Contreras, Owen N. Witte, Clifford A. Lowell, Lindsey R. Whyburn
Publikováno v:
The Journal of Immunology. 171:1850-1858
The development of autoimmunity is correlated with heightened sensitivity of B cells to B cell Ag receptor (BCR) cross-linking. BCR signals are down-regulated by Lyn, which phosphorylates inhibitory receptors. lyn−/− mice have reduced BCR signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272f60a84d0aeda49333284ca96df8fe
https://doi.org/10.4049/jimmunol.171.4.1850
https://doi.org/10.4049/jimmunol.171.4.1850
Publikováno v:
European journal of immunology. 40(7)
Accumulation of plasma cells and autoantibodies against nuclear antigens characterize both human and murine lupus. Understanding how these processes are controlled may reveal novel therapeutic targets for this disease. Mice deficient in Lyn, a negati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a5ab302f19e50bfab979763c390800
https://pubmed.ncbi.nlm.nih.gov/20394076
https://pubmed.ncbi.nlm.nih.gov/20394076
Autor:
Heather L. Wright, Kristina E. Halcomb, Rochelle M. Hinman, Anne B. Satterthwaite, Cristina Contreras, Terry G. Coursey
Publikováno v:
European journal of immunology. 37(4)
The pre-BCR and the BCR regulate B cell development via a signalosome nucleated by the adaptor protein B cell linker protein (BLNK). Formation of this complex facilitates activation of phospholipase C (PLC) gamma2 by Bruton's tyrosine kinase (Btk). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f5bf719b62a009f79c75cf46b602f9
https://pubmed.ncbi.nlm.nih.gov/17372989
https://pubmed.ncbi.nlm.nih.gov/17372989
Autor:
Stephen H. Clarke, Lindsey Randle, Anne B. Satterthwaite, Toni Gutierrez, Cristina Contreras, Kristina E. Halcomb, Rochelle M. Hinman
B-1 cells are important players in the first line of defense against pathogens. According to current models for the origin of B-1 cells, they either represent a separate lineage from conventional B-2 cells or differentiate from conventional B-2 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4fd7a78e721a80994531a1e13f086b
Autor:
Cristina Contreras, Rajita Pappu, Lindsey R. Whyburn, Kristina E. Halcomb, Anne B. Satterthwaite, Owen N. Witte, Andrew C. Chan
Publikováno v:
International immunology. 15(3)
Current models of lymphocyte activation suggest that formation of a signaling complex, or "signalosome", composed of Syk, Bruton's tyrosine kinase (Btk), phospholipase gamma2 and the adaptor protein B cell linker protein (BLNK) is critical for transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4e57dfaacfd1ce9b325c5041938143
https://pubmed.ncbi.nlm.nih.gov/12618482
https://pubmed.ncbi.nlm.nih.gov/12618482