Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Kristina E Howard"'
Autor:
Brian J. Roberts, Aimee E. Mattei, Kristina E. Howard, James L. Weaver, Hao Liu, Sandra Lelias, William D. Martin, Daniela Verthelyi, Eric Pang, Katie J. Edwards, Anne S. De Groot
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Advances in synthetic peptide synthesis have enabled rapid and cost-effective peptide drug manufacturing. For this reason, peptide drugs that were first produced using recombinant DNA (rDNA) technology are now being produced using solid- and liquid-p
Externí odkaz:
https://doaj.org/article/674dd4b85a844bff9f2eb55deb7c7e13
Autor:
Kimberly Chiu, Rebecca Racz, Keith Burkhart, Jeffry Florian, Kevin Ford, M. Iveth Garcia, Robert M. Geiger, Kristina E. Howard, Paula L. Hyland, Omnia A. Ismaiel, Naomi L. Kruhlak, Zhihua Li, Murali K. Matta, Kristin W. Prentice, Aanchal Shah, Lidiya Stavitskaya, Donna A. Volpe, James L. Weaver, Wendy W. Wu, Rodney Rouse, David G. Strauss
Publikováno v:
Frontiers in Medicine, Vol 9 (2023)
The U.S. Food and Drug Administration (FDA) Division of Applied Regulatory Science (DARS) moves new science into the drug review process and addresses emergent regulatory and public health questions for the Agency. By forming interdisciplinary teams,
Externí odkaz:
https://doaj.org/article/9d617856bbe343189c0a88673db07198
Autor:
Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl‐Dimiter Bissig, Brian Soper, Terrence Meeham, Li‐Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb‐Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol Bult, Leonard Shultz
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-16 (2020)
Abstract Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a
Externí odkaz:
https://doaj.org/article/0b7a5df243a34bd59c1903d19ca29593
Autor:
Kenrick M. Semple, Carlos M. Gonzaléz, Melissa Zarr, José R. Austin, Vikram Patel, Kristina E. Howard
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 3, Pp 283-290 (2019)
CD20 monoclonal antibodies are well‐established therapeutics for the treatment of B‐cell malignancies. Several mechanisms of target cell killing occur from anti‐CD20 therapy, including complement‐dependent cytotoxicity (CDC) cell lysis and an
Externí odkaz:
https://doaj.org/article/42101265439442b59af085088b6bc82f
Autor:
James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner
Publikováno v:
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-14 (2017)
Abstract Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate
Externí odkaz:
https://doaj.org/article/785283ca27204af9b663b605868fcf5a
Autor:
Mohammadreza Samieegohar, James L. Weaver, Kristina E. Howard, Anik Chaturbedi, John Mann, Xiaomei Han, Joel Zirkle, Ghazal Arabidarrehdor, Rodney Rouse, Jeffry Florian, David G. Strauss, Zhihua Li
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:882-891
With the ongoing global pandemic of coronavirus disease 2019 (COVID-19), there is an urgent need to accelerate the traditional drug development process. Many studies identified potential COVID-19 therapies based on promising nonclinical data. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb858a7af1bc89e0a169ccb26de6d5a
https://doi.org/10.1002/cpt.2686
https://doi.org/10.1002/cpt.2686
Autor:
Kang Chen, Meiyu Shen, Cyrus Agarabi, Meng-Jung Chiang, Patrick Lynch, Weiming Ouyang, Faruk Sheikh, Sharadrao M. Patil, Ankit B. Shah, Raymond P. Donnelly, Kurt Brorson, Hui Fang, Sarah Rogstad, Phillip Angart, David M. Frucht, Sarah J. Schrieber, Ashwinkumar A. Bhirde, Tao Xie, Kristina E. Howard
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
PEGylated recombinant human granulocyte colony stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following chemotherapy and is being pursued for biosimilar development. One challenge to overcome in pegfilgrasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe45b4fa2041b60abacd838f0477ced2
http://link.springer.com/article/10.1038/s41598-020-59346-z
http://link.springer.com/article/10.1038/s41598-020-59346-z
Autor:
David Sanden, Kristina E. Howard, James L. Weaver, Alick Tan, Bhagyashree Bhagwat, Alan Knapton, Aarron T. Willingham, Hangyi Yan
Publikováno v:
Toxicology and Applied Pharmacology. 372:57-69
Cytokine release syndrome (CRS) is a serious and potentially life-threatening complication typically associated with biological drug products. Pre-clinical testing in vitro and in vivo studies using non-human primates had failed to reliably predict C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72c54b036cd4c76cc7f8e3954efac98
https://doi.org/10.1016/j.taap.2019.03.020
https://doi.org/10.1016/j.taap.2019.03.020
Autor:
José R. Austin, Melissa Zarr, Carlos M. Gonzaléz, Vikram Patel, Kenrick M. Semple, Kristina E. Howard
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 12, Iss 3, Pp 283-290 (2019)
Clinical and Translational Science, Vol 12, Iss 3, Pp 283-290 (2019)
CD20 monoclonal antibodies are well‐established therapeutics for the treatment of B‐cell malignancies. Several mechanisms of target cell killing occur from anti‐CD20 therapy, including complement‐dependent cytotoxicity (CDC) cell lysis and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd396df239fbc47178db47dc29f1f512
https://doi.org/10.1111/cts.12613
https://doi.org/10.1111/cts.12613
Autor:
Michael A. Brehm, Carol J. Bult, Johannes Sam, Florian Klein, Silvia Guionaud, Karl-Dimiter Bissig, James P. Di Santo, Anja Kathrin Wege, Terrence Meeham, Dominique Bonnet, Scott G. Kitchen, Livio Trusolino, Kourosh Saeb-Parsy, Christian Münz, Brian Soper, Kristina E. Howard, Amar Deep Sharma, Renata Stripecke, Estefanía Rodríguez, Leonard D. Shultz, Li-Chin Yao, Andreas Trumpp, Jan Jacob Schuringa
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efabd6d2e172e656481cffd5cf5aba3
http://europepmc.org/articles/PMC7338801
http://europepmc.org/articles/PMC7338801